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Find Clinical Drug Pipeline Developments & Deals by Sionna Therapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          RDD 2025
                          Not Confirmed
                          RDD 2025
                          Not Confirmed

                          Details : The net proceeds from the offering will used to fund the clinical development of NBD1 products, including SION‑719, which is being evaluated for the treatement of Cystic fibrosis.

                          Product Name : SION‑719

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 10, 2025

                          Lead Product(s) : SION‑719

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Goldman Sachs & Co

                          Deal Size : $219.2 million

                          Deal Type : Public Offering

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                          02

                          RDD 2025
                          Not Confirmed
                          RDD 2025
                          Not Confirmed

                          Details : The net proceeds from the offering will used to fund the clinical development of NBD1 products, including SION‑719, which is being evaluated for the treatement of Cystic fibrosis.

                          Product Name : SION‑719

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 06, 2025

                          Lead Product(s) : SION‑719

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Goldman Sachs & Co

                          Deal Size : $191.0 million

                          Deal Type : Public Offering

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                          03

                          RDD 2025
                          Not Confirmed
                          RDD 2025
                          Not Confirmed

                          Details : Proceeds will support clinical development of SION-638, a first-in-class small molecule designed to restore CFTR protein function by stabilizing the first nucleotide-binding domain.

                          Product Name : SION-638

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 03, 2024

                          Lead Product(s) : SION-638

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Enavate Sciences

                          Deal Size : $182.0 million

                          Deal Type : Series C Financing

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                          04

                          RDD 2025
                          Not Confirmed
                          RDD 2025
                          Not Confirmed

                          Details : SION-109 targets the interface between the ICL4 region and NBD1 of the CFTR protein, and is in phase 1 development for treating delta-F508 mutated Cystic Fibrosis.

                          Product Name : SION-109

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 24, 2024

                          Lead Product(s) : SION-109

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          RDD 2025
                          Not Confirmed
                          RDD 2025
                          Not Confirmed

                          Details : SION-638, a novel small molecule designed to target the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

                          Product Name : SION-638

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 12, 2022

                          Lead Product(s) : SION-638

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          RDD 2025
                          Not Confirmed
                          RDD 2025
                          Not Confirmed

                          Details : Sionna is advancing a pipeline of first-in-class small molecules, SION-638, designed to fully restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is defective in CF, by stabilizing CFTR's first nucleotide-b...

                          Product Name : SION-638

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          April 19, 2022

                          Lead Product(s) : SION-638,Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : IND Enabling

                          Sponsor : OrbiMed Advisors

                          Deal Size : $111.0 million

                          Deal Type : Series B Financing

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