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    [{"orgOrder":0,"company":"Sionna Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"SION-109","moa":"CFTR ICL4","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Sionna Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Sionna Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Sionna Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Sionna Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"SION-451","moa":"CFTR NBD1","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Sionna Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Disease","amount2New":0.22,"dosageForm":"Tablet","sponsorNew":"Sionna Therapeutics \/ Goldman Sachs & Co","highestDevelopmentStatusID":"6","companyTruncated":"Sionna Therapeutics \/ Goldman Sachs & Co"},{"orgOrder":0,"company":"Sionna Therapeutics","sponsor":"Goldman Sachs & Co","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Public Offering","leadProduct":"SION\u2011719","moa":"NBD1","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Sionna Therapeutics","amount2":0.22,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0.22,"dosageForm":"Tablet","sponsorNew":"Sionna Therapeutics \/ Goldman Sachs & Co","highestDevelopmentStatusID":"6","companyTruncated":"Sionna Therapeutics \/ Goldman Sachs & Co"}]

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                            01

                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            Lead Product(s) : SION-719

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SION-719 Safety, Tolerability, PD/PK Added to Trikafta

                            Details : SION-719 is a Other Small Molecule drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Cystic Fibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            August 06, 2025

                            Lead Product(s) : SION-719

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SION-451

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SION-451 ± SION-2222/SION-109 Multi-dose Safety, Tolerability & PK In Healthy Adults

                            Details : SION-451 is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Cystic Fibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 25, 2025

                            Lead Product(s) : SION-451

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SION‑719

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $219.2 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Sionna Announces Closing of $219.2 million Upsized Initial Public Offering

                            Details : The net proceeds from the offering will used to fund the clinical development of NBD1 products, including SION‑719, which is being evaluated for the treatement of Cystic fibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            February 10, 2025

                            Lead Product(s) : SION‑719

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $219.2 million

                            Deal Type : Public Offering

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                            04

                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SION‑719

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $191.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Sionna Therapeutics Prices Upsized Initial Public Offering

                            Details : The net proceeds from the offering will used to fund the clinical development of NBD1 products, including SION‑719, which is being evaluated for the treatement of Cystic fibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            February 06, 2025

                            Lead Product(s) : SION‑719

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $191.0 million

                            Deal Type : Public Offering

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                            05

                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            Lead Product(s) : Galicaftor,Navocaftor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Recipient : AbbVie Inc

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Sionna Expands CF Pipeline with AbbVie License Agreement

                            Details : Under the terms of the agreement, Sionna will assume all development for ABBV-2222 (galicaftor), which is being evaluated in combination with navocaftor for the treatment of Cystic Fibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            July 16, 2024

                            Lead Product(s) : Galicaftor,Navocaftor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Recipient : AbbVie Inc

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            06

                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            Lead Product(s) : SION-638

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Enavate Sciences

                            Deal Size : $182.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Sionna Therapeutics Announces $182M Series C for Novel Cystic Fibrosis Molecules

                            Details : Proceeds will support clinical development of SION-638, a first-in-class small molecule designed to restore CFTR protein function by stabilizing the first nucleotide-binding domain.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            March 06, 2024

                            Lead Product(s) : SION-638

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Enavate Sciences

                            Deal Size : $182.0 million

                            Deal Type : Series C Financing

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                            07

                            Sionna Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : SION-109

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sionna Therapeutics Announces Phase 1 Initiation for SION-109 in Cystic Fibrosis

                            Details : SION-109 targets the interface between the ICL4 region and NBD1 of the CFTR protein, and is in phase 1 development for treating delta-F508 mutated Cystic Fibrosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 24, 2024

                            Lead Product(s) : SION-109

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Sionna Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            AIChE Annual Meeting
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                            Lead Product(s) : SION-638

                            Therapeutic Area : Genetic Disease

                            Study Phase : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sionna Therapeutics Announces IND Clearance and Phase 1 Initiation for SION-638 in Cystic Fibrosis

                            Details : SION-638, a novel small molecule designed to target the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 07, 2022

                            Lead Product(s) : SION-638

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : IND Enabling

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Sionna Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Sionna Therapeutics

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                            Lead Product(s) : SION-638,Undisclosed

                            Therapeutic Area : Genetic Disease

                            Study Phase : IND Enabling

                            Sponsor : OrbiMed Advisors

                            Deal Size : $111.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Sionna Therapeutics Launches with $111 Million Series B Financing to Advance Pipeline of Novel Small Molecules...

                            Details : Sionna is advancing a pipeline of first-in-class small molecules, SION-638, designed to fully restore the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is defective in CF, by stabilizing CFTR's first nucleotide-b...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            April 19, 2022

                            Lead Product(s) : SION-638,Undisclosed

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : IND Enabling

                            Sponsor : OrbiMed Advisors

                            Deal Size : $111.0 million

                            Deal Type : Series B Financing

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