
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : $1,700.0 million
Deal Type : Acquisition
Novartis Completes Acquisition of Regulus Therapeutics
Details : Through the acquisition, Novartis will levarage Regulus pipeline, which includes RGLS8429 (farabursen), a potential next-gen oligonucleotide targeting miR-17 for the treatment of ADPKD.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : $800.0 million
June 25, 2025
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : $1,700.0 million
Deal Type : Acquisition

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : $1,700.0 million
Deal Type : Acquisition
Novartis Acquires Regulus and Farabursen for ADPKD Treatment
Details : Through the acquisition, Novartis will levarage Regulus pipeline, which includes RGLS8429 (farabursen), a potential next-gen oligonucleotide targeting miR-17 for the treatment of ADPKD.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : $800.0 million
April 30, 2025
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : $1,700.0 million
Deal Type : Acquisition

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Regulus Completes Phase 1b Trial Of Farabursen for ADPKD Treatment
Details : RGLS8429 (farabursen) is an miR-17 inhibitor, antisense oligonucleotide, which is currently being evaluated for the treatment of autosomal dominant polycystic kidney disease.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
March 27, 2025
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Farabursen ADPKD Program Gains Positive Updates from Regulus
Details : RGLS8429 (farabursen) is an miR-17 inhibitor, antisense oligonucleotide, which is currently being evaluated for the treatment of autosomal dominant polycystic kidney disease.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
January 29, 2025
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Regulus Completes Enrollment in MAD Trial For RGLS8429 For Kidney Disease
Details : RGLS8429 is a novel, next generation oligonucleotide designed to inhibit miR-17. It is being evaluated for the treatment of autosomal dominant polycystic kidney disease.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
October 08, 2024
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Regulus Announces Positive Data from Phase 1b Trial of RGLS8429 for ADPKD
Details : RGLS8429 is a novel, next generation oligonucleotide designed to inhibit miR-17. It is being evaluated for the treatment of autosomal dominant polycystic kidney disease.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
June 24, 2024
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Regulus Advances to Cohort 4 in Phase 1b Trial of RGLS8429 for Polycystic Kidney Disease
Details : RGLS8429 is a novel, next generation oligonucleotide designed to inhibit miR-17 and to preferentially target the kidney. It is being evaluated for autosomal dominant polycystic kidney disease.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
May 06, 2024
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Regulus Announces Positive Topline Data from Cohort 2 of RGLS8429 in PKD
Details : RGLS8429 is a novel, next generation oligonucleotide designed to inhibit miR-17 and to preferentially target the kidney. It is being evaluated for autosomal dominant polycystic kidney disease.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
March 12, 2024
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Regulus Therapeutics Completes Enrollment in Phase 1b Trial Of RGLS8429
Details : RGLS8429 is a next-gen oligonucleotide designed to inhibit miR-17, targeting the kidney, in Phase 1 for Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
January 02, 2024
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : RGLS8429 is a novel, next generation oligonucleotide for the treatment of ADPKD designed to inhibit miR-17 and to preferentially target the kidney. It is being investigated for the autosomal dominant polycystic kidney disease.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Inapplicable
November 02, 2023
Lead Product(s) : Farabursen
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
