Athena Athena

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Applicable","upfrontCash":"Not Applicable","newsHeadline":"European Medicines Agency Validates Type II Variation Application for PADCEV\u00ae (enfortumab vedotin) with KEYTRUDA\u00ae (pembrolizumab) for First-Line Treatment of Advanced Bladder Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Large molecule","productStatus":"Approved","date":"January 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"Pfizer Inc","sponsor":"Iterum Therapeutics","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Iterum Therapeutics Announces Positive Topline Results from its Phase 3 REASSURE Clinical Trial of Oral Sulopenem in Uncomplicated Urinary Tract Infections","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2024","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Phase III"},{"orgOrder":0,"company":"Pfizer Inc","sponsor":"Arvinas","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Arvinas and Pfizers Vepdegestrant (ARV-471) Receives FDA Fast Track Designation for the Treatment of Patients with ER+\/HER2- Metastatic Breast Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"Pfizer Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"European Commission Approves Pfizer\u2019s VELSIPITY\u00ae for Patients with Moderately to Severely Active Ulcerative Colitis","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Approved","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"February 2024","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Approved"}]

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            ARV-471 (vepdegestrant) is an investigational, orally bioavailable PROTAC protein degrader designed to specifically target and degrade the estrogen receptor. It is being evaluated in phase 3 clinical trials for the treatment of patients with ER+/HER2- breast cancer.

            Lead Product(s): Vepdegestrant

            Therapeutic Area: Oncology Product Name: ARV-471

            Highest Development Status: Phase III Product Type: Small molecule

            Recipient: Arvinas

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 06, 2024

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            Oral Sulopenem (sulopenem etzadroxil/probenecid) is a cell wall inhibitor which is being evaluated in phase 3 clinical trials for the treatment of uncomplicated urinary tract infections & cystitis.

            Lead Product(s): Sulopenem Etzadroxil,Probenecid

            Therapeutic Area: Infections and Infectious Diseases Product Name: PF-03709270

            Highest Development Status: Phase III Product Type: Small molecule

            Recipient: Iterum Therapeutics

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 30, 2024

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            Tivdak (tisotumab vedotin-tftv) is an antibody-drug conjugate (ADC) composed of Genmab’s human monoclonal antibody directed to tissue factor (TF) and Pfizer’s ADC technology. It is being evaluated in phase 3 studies for the treatment of recurrent or metastatic cervical cancer.

            Lead Product(s): Tisotumab Vedotin

            Therapeutic Area: Oncology Product Name: Tivdak

            Highest Development Status: Phase III Product Type: Large molecule

            Recipient: Genmab

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 09, 2024

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            BEQVEZ (fidanacogene elaparvovec) is an adeno-associated viral (AAV) vector-based gene therapy approved for the treatment of adults with moderately severe to severe hemophilia B.

            Lead Product(s): Fidanacogene elaparvovec

            Therapeutic Area: Genetic Disease Product Name: Beqvez

            Highest Development Status: Approved Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 03, 2024

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            The agreement provides access to Serina's POZ polymer technology for potential use in lipid nanoparticle (LNP) formulations for RNA-based therapeutics.

            Lead Product(s): RNA-based Therapeutic

            Therapeutic Area: Technology Product Name: Undisclosed

            Highest Development Status: Discovery Platform Product Type: Large molecule

            Recipient: Serina Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement November 17, 2023

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            Abrysvo is the company’s bivalent RSV prefusion F (RSVpreF) vaccine approved by FDA for the prevention of lower respiratory tract disease caused by RSV Infants through maternal immunization and older adults.

            Lead Product(s): RSVpreF

            Therapeutic Area: Infections and Infectious Diseases Product Name: Abrysvo

            Highest Development Status: Approved Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 22, 2023

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            BHV2000 (taldefgrobep-alpha) is a fully human anti-myostatin recombinant protein that lowers free myostatin and acts as an Activin 2b receptor antagonist with the myostatin-taldefgrobep complex, thereby blocking myostatin signaling in skeletal muscles.

            Lead Product(s): Taldefgrobep-alfa

            Therapeutic Area: Genetic Disease Product Name: BHV2000

            Highest Development Status: Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 14, 2023

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            VLA15 (PF-07307405) is the only Lyme disease vaccine candidate under development. It is a multivalent protein subunit vaccine which targets the outer surface protein A (OspA) of borrelia burgdorferi, the bacteria that cause lyme disease.

            Lead Product(s): PF-07307405

            Therapeutic Area: Infections and Infectious Diseases Product Name: VLA15

            Highest Development Status: Phase III Product Type: Vaccine

            Recipient: Valneva

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 07, 2023

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            Pfizer and BioNTech announce Positive CHMP Opinion for Omicron XBB.1.5-adapted COVID-19 Vaccine, Recommendation based on results of pre-clinical studies showing that the vaccine shows positive response against multiple XBB-related sublineages, including XBB.1.5, XBB.1.16, XBB.2.3, and EG.5.1 (Eris).

            Lead Product(s): Omicron XBB.1.5-adapted Monovalent COVID-19 Vaccine

            Therapeutic Area: Infections and Infectious Diseases Product Name: Comirnaty Omicron XBB.1.5

            Highest Development Status: Approved Product Type: Vaccine

            Partner/Sponsor/Collaborator: BioNTech

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 30, 2023

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            COMIRNATY® (tozinameran), a COVID-19 mRNA vaccine is approved for active immunization to prevent coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals 12 years of age and older.

            Lead Product(s): Tozinameran

            Therapeutic Area: Infections and Infectious Diseases Product Name: Comirnaty

            Highest Development Status: Approved Product Type: Vaccine

            Recipient: BioNTech

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 30, 2023

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