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Association of Clinical Trials","sponsor":"Nanjing Geneseeq Technology Inc.","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Osimertinib Mesylate","moa":"Epidermal growth factor receptor erbB1","graph1":"Oncology","graph2":"Undisclosed","graph3":"Guangdong Association of Clinical Trials","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Guangdong Association of Clinical Trials \/ Nanjing Geneseeq Technology Inc.","highestDevelopmentStatusID":"1","companyTruncated":"Guangdong Association of Clinical Trials \/ Nanjing Geneseeq Technology Inc."}]

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                          01

                          ChemOutsourcing
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                          Details : Orpathys (savolitinib) in combination with Tagrisso (osimertinib) is approved for the treatment of advanced or metastatic EGFR mutation-positive non-squamous non-small cell lung cancer.

                          Product Name : Orpathys

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 30, 2025

                          Lead Product(s) : Savolitinib,Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          ChemOutsourcing
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                          ChemOutsourcing
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                          Details : Tagrisso aka osimertinib is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of advanced non-small cell lung cancer (NSCLC).

                          Product Name : Tagrisso

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 29, 2025

                          Lead Product(s) : Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The DoD grant will help the company to advance it's early stage product ENV105 (carotuximab), which is being evaluated for NSCLC.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          April 17, 2025

                          Lead Product(s) : Carotuximab,Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : U S Department of Defense

                          Deal Size : $0.8 million

                          Deal Type : Funding

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                          04

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : under the agreement, LaunXP receives exclusive development and commercialization rights for APL-101 (vebreltinib) in combination with an EGFR inhibitor for the treatment of non-small cell lung cancer.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : $10.0 million

                          March 31, 2025

                          Lead Product(s) : Vebreltinib,Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : LaunXP Biomedical

                          Deal Size : $60.0 million

                          Deal Type : Agreement

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                          05

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : NXP900 is an oral SRC/YES1 kinase inhibitor is being investigated in combination with osimertinib (Tagrisso®) in EGFR-mutated non-small cell lung cancer (NSCLC) models.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 05, 2025

                          Lead Product(s) : NXP900,Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Orpathys is an MET tyrosine kinase inhibitor. Tagrisso is a third-generation, irreversible EGFR TKI. These are being evaluated in combination with EGFR mutation-positive non-small cell lung cancer.

                          Product Name : Orpathys

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 01, 2025

                          Lead Product(s) : Savolitinib,Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Orpathys (savolitinib) is an oral, potent and highly selective MET tyrosine kinase inhibitor. It is investigated in combination with osimertinib for EGFR-mutated NSCLC.

                          Product Name : Orpathys

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 11, 2024

                          Lead Product(s) : Savolitinib,Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Guangdong Association of Clinical Trials

                          Country arrow
                          ChemOutsourcing
                          Not Confirmed

                          Guangdong Association of Clinical Trials

                          Country arrow
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 29, 2024

                          Lead Product(s) : Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Undisclosed

                          Sponsor : Nanjing Geneseeq Technology Inc.

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Tagrisso (osimertinib) is being evaluated in the mid-stage clinical trial studies in combination with Orpathys (savolitinib) for EFGR-mutated non-small cell lung cancer.

                          Product Name : Tagrisso

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 16, 2024

                          Lead Product(s) : Osimertinib Mesylate,Savolitinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Tagrisso (osimertinib) is a third-generation, irreversible EGFR-TKI, which is being evaluated for patients with unresectable, Stage III EGFR-mutated non small cell lung cancer.

                          Product Name : Tagrisso

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 06, 2024

                          Lead Product(s) : Osimertinib Mesylate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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