
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Sozinibercept,Aflibercept
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Opthea Announces COAST Phase 3 Trial Topline Results
Details : OPT-302 (sozinibercept) is a VEGF-C/D inhibitor fusion protein, which is currently being evaluated for the treatment of neovascular age-related macular degeneration.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
March 24, 2025
Lead Product(s) : Sozinibercept,Aflibercept
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Sozinibercept,Aflibercept
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : $150.0 million
Deal Type : Private Placement
Opthea Announces Entitlement Offer to Raise A$227.3 Million (US$150 Million)
Details : The Company will fund the anticipated Phase 3 readouts evaluating OPT-302 (sozinibercept), a inhibitor of VEGF-C and D, with Aflibercept, for Neovascular Age-related Macular Degeneration.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Undisclosed
June 11, 2024
Lead Product(s) : Sozinibercept,Aflibercept
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : $150.0 million
Deal Type : Private Placement

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Lead Product(s) : Sozinibercept,Aflibercept
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Opthea Completes Enrollment in Pivotal Ph 3 Clinical Program with Sozinibercept in Wet AMD
Details : OPT-302 (sozinibercept) is a VEGF-C/D inhibitor, which is being evaluated in combination with aflibercept, for the treatment of wet Age-related Macular Degeneration.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
May 28, 2024
Lead Product(s) : Sozinibercept,Aflibercept
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Sozinibercept,Aflibercept
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Opthea Completes Enrollment in First Pivotal Trial with Sozinibercept
Details : OPT-302 (sozinibercept) is a VEGF-C/D inhibitor, which is being evaluated in combination with aflibercept, an anti-VEGF-A therapy, for the treatment of wet Age-related Macular Degeneration (wet AMD).
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
February 14, 2024
Lead Product(s) : Sozinibercept,Aflibercept
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Carlyle
Deal Size : $170.0 million
Deal Type : Financing
Opthea to Receive US$35M Commitment and Additional US$50M Funding
Details : The funding aims to support the OPT-302 (sozinibercept) in combination with ranibizumab, which is the first-in-class VEGF-C/D ‘trap’ in clinical development for Wet age-related macular degeneration.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Undisclosed
December 27, 2023
Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Carlyle
Deal Size : $170.0 million
Deal Type : Financing

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Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : $57.6 million
Deal Type : Financing
Details : The company intends to use the net proceeds for advancing the Phase 3 clinical trials ShORe and COAST for OPT-302 (sozinibercept), a novel inhibitor of vascular endothelial growth factor (VEGF)-C and VEGF-D, for the treatment of wet AMD.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Undisclosed
August 28, 2023
Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : $57.6 million
Deal Type : Financing

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Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Opthea Announces “Sozinibercept” as the Nonproprietary Drug Name for OPT-302
Details : OPT-302 (sozinibercept) is a novel recombinant trap fusion protein targeting inhibition of vascular endothelial growth factors C and D (VEGF-C and VEGF-C), two ligand mediators of angiogenesis and vascular leakage involved in retinal vascular diseases.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
July 26, 2023
Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : OPT-302, a VEGF-C/D inhibitor being investigated for neovascular age-related macular degeneration. It binds to and neutralizes the activity of VEGF-C and VEGF-D by preventing ligand binding to the endogenous receptors VEGFR-2 and VEGFR-3.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
February 13, 2023
Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Of the 366 participants dosed for OPT-302, 66 (18%) were identified as having PCV lesions at baseline based on multimodal imaging analysis of color fundus photography, fluorescein angiography and SD-OCT.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
May 05, 2022
Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Opthea Presenting Clinical Data at ARVO 2022 Annual Meeting
Details : OPT-302 is a first-in-class VEGF-C/D inhibitor. It is a soluble fusion protein comprising immunoglobulin-like domains 1 to 3 of extracellular domain of vascular endothelial growth factor receptor 3 fused to Fc fragment of human IgG1.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
April 29, 2022
Lead Product(s) : Sozinibercept,Ranibizumab
Therapeutic Area : Ophthalmology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
