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            Details:

            The financing will support advancement of Mogrify’s dedicated pipeline of in vivo reprogramming therapies through pre-clinical translation, continued platform optimization, and facilitation of new and existing biopharma collaborations.

            Lead Product(s): Undisclosed

            Therapeutic Area: Ophthalmology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Astellas Venture Management

            Deal Size: $46.0 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing October 02, 2023

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            With the financing, CTx will continue the development and complete a Phase Ib clinical proof of concept of its lead product CTx001. CTx001 is a highly innovative AAV gene therapy for the treatment of Geograpic Atrophy (GA) secondary to dry age-related macular degeneration.

            Lead Product(s): CTX001

            Therapeutic Area: Ophthalmology Product Name: CTx001

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Gimv

            Deal Size: $78.9 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing April 17, 2023

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            rVA576 (nomacopan) is a novel bispecific inhibitor of complement C5 and leukotriene B4 (LTB4) in clinical development for pediatric and adult HSCT-TMA.

            Lead Product(s): Nomacopan

            Therapeutic Area: Ophthalmology Product Name: rVA576

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 15, 2023

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            The OK-101 drug candidate displays potent anti-inflammatory activity in animal models of DED. OK-101 also reduces Corneal Neuropathic Pain (CNP) in a ciliary nerve ligation animal model of CNP.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: AmbioPharm

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 30, 2022

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            The new data showing extended dose intervals, together with data previously presented, showing LTB4 inhibition by PAS-nomacopan may also reduce risk of sight-threatening CNV, suggest PAS-rVA576(nomacopan) may be a potential novel and effective treatment option for GA.

            Lead Product(s): PAS-Nomacopan

            Therapeutic Area: Ophthalmology Product Name: rVA576

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 28, 2022

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            Details:

            OKYO intends to use the net proceeds from this Offering: (i) to advance OK-101 to the filing of an IND to treat DED; (ii) to fund the initial Phase 2 clinical trial of OK-101 in DED patients; and (iii) for working capital and other general corporate purposes.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: ThinkEquity

            Deal Size: $2.5 million Upfront Cash: Undisclosed

            Deal Type: Public Offering May 19, 2022

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            OKYO Pharma intends to use the net proceeds of the offering to advance OK-101 to the filing of an IND to treat DED, to fund the initial Phase 2 clinical trial of OK-101 in DED patients, and the remaining proceeds for working capital and other general corporate purposes.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: ThinkEquity

            Deal Size: $2.5 million Upfront Cash: Undisclosed

            Deal Type: Public Offering May 16, 2022

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            Presentation highlight OK-101, agonist of chemerin receptor ChemR23, ability to reduce neuropathic corneal pain in mouse model of ciliary nerve ligation; 2nd presentation will present efficacy data of OK-201, a BAM8-22 peptide analog, in neuropathic corneal pain in same model.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 27, 2022

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            Details:

            OK101, lead pre-clinical compound and a novel long-acting GPCR-based anti-inflammatory drug candidate, company issues US Patent that covers key claim information of OK101 useful in treatment of dry eye disease.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 14, 2021

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            Details:

            OK-101 is designed to combat washout through the inclusion of a lipid ‘anchor’ within the candidate drug molecule to enhance the residence time of OK-101 on the ocular surface to target the inflammatory cells.

            Lead Product(s): OK-101

            Therapeutic Area: Ophthalmology Product Name: OK-101

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 29, 2021

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