[{"orgOrder":0,"company":"Can-Fite BioPharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"ISRAEL","productType":"Miscellaneous","year":"2013","type":"Inapplicable","leadProduct":"Piclidenoson","moa":"Adenosine A3 receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Can-Fite BioPharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Can-Fite BioPharma \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Can-Fite BioPharma \/ Undisclosed"},{"orgOrder":0,"company":"Azura Ophthalmics","sponsor":"Avania","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"ISRAEL","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"AZR-MD-001","moa":"Mitosis","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Azura Ophthalmics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ointment","sponsorNew":"Azura Ophthalmics \/ Avania","highestDevelopmentStatusID":"8","companyTruncated":"Azura Ophthalmics \/ Avania"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : AZR-MD-001 harnesses the power of selenium sulfide (SeS2) in an easy-to-use ophthalmic ointment preparation applied directly to the meibomian glands on the eye lid.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          October 19, 2022

                          Lead Product(s) : Selenium Sulfide

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : AZR-MD-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Contact Lens Discomfort.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 21, 2022

                          Lead Product(s) : AZR-MD-001

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Avania

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Company received important feedback on its trial design and program for its TRS01 Phase 3 program in uveitis, including feedback on its nonclinical and CMC plans supporting submission of a New Drug Application (NDA) in the U.S.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          December 17, 2020

                          Lead Product(s) : TRS01,Adapalene

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Proceeds from the financing will be used to advance Orasis’ lead eye drop candidate for the treatment of presbyopia symptoms through completion of its Phase 3 clinical trials.

                          Product Name : PresbiDrops

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          September 10, 2020

                          Lead Product(s) : CSF-1

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Bluestem Capital

                          Deal Size : $30.0 million

                          Deal Type : Series C Financing

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                          05

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : AZR-MD-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Meibomian Gland Dysfunction.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          May 18, 2020

                          Lead Product(s) : AZR-MD-001

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Avania

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : AZR-MD-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Meibomian Gland Dysfunction.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          June 03, 2019

                          Lead Product(s) : AZR-MD-001

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : University of New South Wales

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : Colony Stimulating Factor 1 is a drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Presbyopia.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          March 21, 2019

                          Lead Product(s) : Colony Stimulating Factor 1

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : AZR-MD-001 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Meibomian Gland Dysfunction.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          August 29, 2018

                          Lead Product(s) : AZR-MD-001

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Syneos Health | Cliantha Research

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : PresbiDrops (CSF-1) is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Presbyopia.

                          Product Name : PresbiDrops

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          November 17, 2016

                          Lead Product(s) : CSF-1

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AIChE Annual Meeting
                          Not Confirmed
                          AIChE Annual Meeting
                          Not Confirmed

                          Details : PresbiDrops (CSF-1) is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Presbyopia.

                          Product Name : PresbiDrops

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 20, 2016

                          Lead Product(s) : CSF-1

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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