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Find Clinical Drug Pipeline Developments & Deals by Oncternal Therapeutics
ONCT-534 is a dual-action androgen receptor inhibitor, which is under phase 1/2 clinical development for the treatment of R/R metastatic castration-resistant prostate cancer.
ONCT-808 is an investigational autologous chimeric antigen receptor T (CAR T) cell therapy that targets Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1). It is being evaluated for the treatment of relapsed or refractory aggressive b-cell lymphoma.
ONCT-534 is a dual-action androgen receptor inhibitor (DAARI) that interacts with both the N-terminal domain and the ligand-binding domain (LBD) of the androgen receptor (AR), inhibiting cell growth and inducing AR degradation.
ONCT-534 is a dual-action androgen receptor inhibitor (DAARI) that interacts with both the N-terminal domain and the ligand-binding domain (LBD) of the androgen receptor (AR), inhibiting cell growth and inducing AR degradation.
ONCT-808, a ROR1 targeting autologous CAR T cell therapy, is being tested in a Phase 1/2 clinical trial for the treatment of patients with relapsed or refractory aggressive B-cell lymphoma, including those who have failed previous CD19 CAR T therapy.
Zilovertamab (UC-961) continues to be evaluated in an ongoing Phase 1/2 study in combination with ibrutinib for the treatment of patients with MCL and chronic lymphocytic leukemia (CLL), and this trial was recently amended to include patients with marginal zone lymphoma.
ONCT-808, an autologous chimeric antigen receptor (CAR) T therapy targeting ROR1, in patients with aggressive B cell non-Hodgkin’s lymphoma (B NHL), including those who have failed previous CD19 CAR T treatment.
Patients with such an inadequate response (PR or SD) will be randomized (1:1) to receive zilovertamab (UC961) (600mg administered by IV every 2 weeks for 3 administrations and then every 4 weeks thereafter) or placebo, while continuing to receive oral ibrutinib.
Under the terms of the collaboration, the supply of ibrutinib will support the company’s global registrational Phase 3 clinical trial of zilovertamab for the treatment of patients with relapsed or refractory mantle cell lymphoma (MCL), ZILO-301.
In preclinical research, VLS-101 (zilovertamab), an investigational monoclonal antibody designed to inhibit ROR1, a type I tyrosine kinase-like orphan receptor.demonstrated anti-tumor activity in a series of studies.
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