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Poseida will apply licensed UniDab binders, which possess significant advantages over traditional single chain variable antibody fragment (scFv) binders, to develop its next generation CAR-T therapies. Targets were not disclosed.
The partnership aims to explore the combination of ONK’s ONKT105, CISH + TGFβR2 double knock-out (KO), sIL-15 knock-in (KI) allogeneic NK cell therapy with NAYA’s GPC3-targeted NY-303 FLEX-NK™ bispecific antibody for the treatment of cancer.
Nucleotide-based Therapy drug conjugate is the first application of their targeted intracellular delivery platform, GEENIE, for glioblastoma multiforme treatment.
The collaboration aims to evaluate the novel combination of CT7001 (samuraciclib), an oral, first-in-class inhibitor of CDK7, and Arvinas’ ARV-471 (vepdegestrant), an investigational oral PROTAC® estrogen receptor protein degrader being developed in metastatic breast cancer.
ONKT102 is the company’s most advanced program, and is being advanced towards clinical development as a potential treatment for patients with relapsed or refractory multiple myeloma (MM).
miRNAs are noncoding RNAs that each affects the expression of hundreds of coding genes. The Castling technology utilizes miRNA pairs that impact immune-cells activity when in the microenvironment of cancer cells.
JZP815 did not induce significant paradoxical pathway activation, observed with approved first generation BRAF-selective inhibitor, demonstrated equivalent cellular potencies for MAPK pathway inhibition driven by either mutant RAF monomers in tumor cells.
JZP815 is an investigational, pre-clinical stage, next-generation pan-RAF kinase inhibitor, demonstrated that it selectively and potently inhibits mutant A, B and CRAF kinases, and demonstrated anti-tumor activity in RAS- and RAF-mutant xenograft models.
ONKT102 combines an optimized affinity CD38 CAR and a TRAILv targeting DR5, intended for the treatment of patients with relapsed/refractory multiple myeloma.
The study evaluated the antitumor efficacy and mechanism of action of mALKS 4230, a mouse ortholog of ALKS 4230, and lucitanib as monotherapies and in combination in a preclinical syngeneic mouse model of colon cancer.