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Find Novel Oncology Drugs in Preclinical Development in FRANCE
Kiadis’ proprietary platform is based on allogeneic or ‘off-the-shelf' NK cells from a healthy donor. NK cells seek and identify malignant cancer cells and have broad application across various tumor types.
The article describes the synergy of mbIL21 expanded NK cells (FC21-NK) modified with a CD38 gene knockout together with an anti-CD38 monoclonal antibody (mAb) for enhanced killing of multiple myeloma cells.
Combination of Kiadis’ CD38 knock out K-NK cells with Sanofi’s anti-CD38 antibody Sarclisa® enables optimal tumor cell killing, and offers a potential first-in-class treatment for patients with multiple myeloma.
Poster presentation demonstrates similarity between K-NK cells produced with FC21 and PM21 and preclinical data with enhanced K-NK cell production and functionality using PM21.Fc.
AQEMIA will leverage the net proceeds to accelerate the growth of its wholly-owned pipeline of small molecule drug discovery projects and assets as well as further scale its proprietary GenAI and deep physics drug discovery platform.
The net proceeds will be used to develop PDC*neo+, a personalized therapeutic vaccine for colorectal cancer using PDC*line Pharma's innovative PDC*line technology.
The financing will secure the preparation on Odimma's First-in-Man clinical trial with ODI-2001, an innovative first-in-class personalized immunotherapy against cancer.
STC-1010 is a next-generation cancer vaccine immunotherapy that targets tumor antigen, it is designed to combat colorectal cancer (CRC) including MSS and MSI-H populations.
The partnership aims at the bioproduction of innovative therapy drugs (ITD) and will lead in 2023 to the production of clinical batches for the Fist-In-Human study of STC-1010, Brenus's lead candidate, targeting colorectal cancer.
MBK-103 is an antibody-drug conjugate targeting the folate receptor alpha which has demonstrated excellent ex vivo stability in human plasma, which should lead to a lower off-target toxicity. It is being investigated for folate receptor alpha positive cancer patients.