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Find Novel Oncology Drugs in Preclinical Development in FRANCE

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            Lead Product(s): IPH6101

            Therapeutic Area: Oncology Product Name: SAR443579

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Sanofi

            Deal Size: $8.4 million Upfront Cash: Undisclosed

            Deal Type: Collaboration January 05, 2021

            Details:

            Sanofi has taken a decision on the progress of the IPH6101/SAR443579 investigational new drug enabling studies. Innate Pharma is eligible for up to €400m in development and commercial milestone payments as well as net sales royalties, under the terms of this collaboration.

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            Lead Product(s): BT-001

            Therapeutic Area: Oncology Product Name: BT-001

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: BioInvent

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 21, 2020

            Details:

            BT-001 is a Vaccinia virus generated using Transgene’s Invir.IO™ platform and its large-capacity VVcopTK-RR- oncolytic virus, designed to encode a Treg-depleting human recombinant anti-CTLA4 antibody generated by BioInvent’s n-CoDeR®/F.I.R.S.T™, and a human GM-CSF cytokine.

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            Lead Product(s): AB8939

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 10, 2020

            Details:

            The therapeutic potential of AB8939 in AML is demonstrated using Ara-C resistant and azacitidine resistant patient-derived xenograft (PDX) models.

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            Lead Product(s): BiCKI-IL-7

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 10, 2020

            Details:

            The AACR update presentations show that BiCKI®-IL-7 will help overcome resistance mechanisms to anti-PD(L)-1 therapies and could potentially address the needs of a patient population in immune escape from checkpoint inhibitor treatment.

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            Lead Product(s): Anti-CLEC-1 monoclonal antibody

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 09, 2020

            Details:

            OSE Immunotherapeutics’ poster presentation featured CLEC-1 antagonist monoclonal antibodies, which have been identified as an innovative immunotherapy that releases the brakes on macrophage phagocytosis and dendritic cells and demonstrates synergistic anti-cancer effects.

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            Lead Product(s): BT-001

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 15, 2020

            Details:

            AACR abstract outlines the broad therapeutic potential of BT-001, an oncolytic virus encoding an anti-CTLA4 antibody.

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            Lead Product(s): STI-001

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Portage Biotech

            Deal Size: $0.9 million Upfront Cash: Undisclosed

            Deal Type: Financing May 11, 2020

            Details:

            Stimunity has reached a major milestone in its preclinical development plan and the additional financing will enable it to start the manufacturing of its biologic cGAMP-VLP (STI-001) lead compound.

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            Lead Product(s): BT-001

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 03, 2020

            Details:

            Comprehensive data package supports pending clinical trial application for the first-in-human study of BT-001.

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            Lead Product(s): OX401

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 27, 2020

            Details:

            The data will showcase the high affinity with PARP that leads to DDR inhibition, metabolic exhaustion and activation of the innate immune response, specifically in tumoral cells.

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            Lead Product(s): ABD-3001

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Xerys Funds

            Deal Size: $9.8 million Upfront Cash: Undisclosed

            Deal Type: Funding February 26, 2020

            Details:

            Advanced BioDesign will finalise its preclinical studies and submit a clinical trial authorization to start clinical phase I in AML in early 2021.