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Center"},{"orgOrder":0,"company":"GUERBET","sponsor":"NUCLIDIUM","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"FRANCE","productType":"Undisclosed","year":"2024","type":"Partnership","leadProduct":"NuriPro","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"GUERBET","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"GUERBET \/ NUCLIDIUM","highestDevelopmentStatusID":"4","companyTruncated":"GUERBET \/ NUCLIDIUM"},{"orgOrder":0,"company":"PDC*line Pharma","sponsor":"BioWin","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"FRANCE","productType":"Vaccine","year":"2024","type":"Financing","leadProduct":"Dendritic Cell Vaccine","moa":"Cellular tumor antigen p53 (TP53)","graph1":"Oncology","graph2":"Preclinical","graph3":"PDC*line Pharma","amount2":0.01,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0.01,"dosageForm":"Undisclosed","sponsorNew":"PDC*line Pharma \/ BioWin","highestDevelopmentStatusID":"4","companyTruncated":"PDC*line Pharma \/ BioWin"}]

Find Novel Oncology Drugs in Preclinical Development in FRANCE

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : K-NK002

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Poster presentation demonstrates similarity between K-NK cells produced with FC21 and PM21 and preclinical data with enhanced K-NK cell production and functionality using PM21.Fc.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          December 05, 2020

                          Lead Product(s) : K-NK002

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          02

                          Lead Product(s) : K-NK004,Isatuximab

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Sponsor : Sanofi

                          Deal Size : $986.0 million

                          Deal Type : Collaboration

                          Details : Combination of Kiadis’ CD38 knock out K-NK cells with Sanofi’s anti-CD38 antibody Sarclisa® enables optimal tumor cell killing, and offers a potential first-in-class treatment for patients with multiple myeloma.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : $20.4 million

                          August 07, 2020

                          Lead Product(s) : K-NK004,Isatuximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Sanofi

                          Deal Size : $986.0 million

                          Deal Type : Collaboration

                          Sanofi Company Banner

                          03

                          Lead Product(s) : K-NK003,Isatuximab

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : The article describes the synergy of mbIL21 expanded NK cells (FC21-NK) modified with a CD38 gene knockout together with an anti-CD38 monoclonal antibody (mAb) for enhanced killing of multiple myeloma cells.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          July 22, 2020

                          Lead Product(s) : K-NK003,Isatuximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          04

                          Lead Product(s) : K-NK004,Isatuximab

                          Therapeutic Area : Oncology

                          Study Phase : Preclinical

                          Sponsor : Sanofi

                          Deal Size : $359.0 million

                          Deal Type : Acquisition

                          Details : Kiadis’ proprietary platform is based on allogeneic or ‘off-the-shelf' NK cells from a healthy donor. NK cells seek and identify malignant cancer cells and have broad application across various tumor types.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          February 11, 2020

                          Lead Product(s) : K-NK004,Isatuximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Sanofi

                          Deal Size : $359.0 million

                          Deal Type : Acquisition

                          Sanofi Company Banner

                          05

                          ESCRS
                          Not Confirmed
                          ESCRS
                          Not Confirmed

                          Details : The funding will help accelerate the industrialization of Allogenica’s lead-candidate CAR-T, called the XL-001 for treating CD19-positive blood cancers.

                          Product Name : Undisclosed

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 19, 2025

                          Lead Product(s) : XL-001

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : French Government

                          Deal Size : $2.7 million

                          Deal Type : Funding

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                          06

                          ESCRS
                          Not Confirmed
                          ESCRS
                          Not Confirmed

                          Details : This new agreement is based on the initial multi-year research collaboration between MSK and OSE Immunotherapeutics to explore the preclinical potential against IL-7R Acute Lymphoblastic Leukemia.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          June 24, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Memorial Sloan Kettering Cancer Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          ESCRS
                          Not Confirmed
                          ESCRS
                          Not Confirmed

                          Details : IPH45, a preclinical stage, novel and differentiated topoisomerase I inhibitor Antibody Drug Conjugate (ADC) targeting Nectin-4, which is being developed for tumors expressing Nectin-4.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          June 03, 2024

                          Lead Product(s) : IPH45

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          ESCRS
                          Not Confirmed
                          ESCRS
                          Not Confirmed

                          Details : NUCLIDIUM and Guerbet will support the advancement of targeted copper-based radiotheranostics, 61Cu-based NuriPro, which binds specifically to PSMA, for the treatment of prostate cancer.

                          Product Name : NuriPro

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          May 22, 2024

                          Lead Product(s) : NuriPro

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : NUCLIDIUM

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          09

                          ESCRS
                          Not Confirmed
                          ESCRS
                          Not Confirmed

                          Details : DT-9045 is a novel protease-activated receptor 2 (PAR2) negative allosteric modulator, small molecule drug candidate. It is being evaluated for the treatment of cancer.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 26, 2024

                          Lead Product(s) : DT-9045

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          ESCRS
                          Not Confirmed
                          ESCRS
                          Not Confirmed

                          Details : Ipsen secures global rights to develop, manufacture and commercialize BMX-502, a pre-clinical bispecific antibody engaging MAIT cells, targeting GPC3 to kill cancer cells.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          February 12, 2024

                          Lead Product(s) : BMX-502

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Ipsen

                          Deal Size : $610.0 million

                          Deal Type : Licensing Agreement

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