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Find Oncology Drugs in Phase II Clinical Development in ISRAEL

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            Lead Product(s): Namodenoson

            Therapeutic Area: Oncology Product Name: CF102

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 22, 2021

            Details:

            In the trial Namodenoson continues to demonstrate a good safety profile and is well tolerated with no severe adverse events reported.

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            Lead Product(s): MWPC005

            Therapeutic Area: Oncology Product Name: MWPC005

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Soroka Medical Cente

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 22, 2021

            Details:

            MediWound recently submitted a protocol to the FDA for a phase I/II clinical study of MWPC005 for the treatment of basal cell carcinoma (BCC) and is preparing to initiate this study in the United States in the second quarter of 2021.

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            Lead Product(s): Aspacytarabine

            Therapeutic Area: Oncology Product Name: BST-236

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 17, 2020

            Details:

            Aspacytarabine, Biosight’s lead product candidate, is a novel antimetabolite designed to provide the benefit of intensive chemotherapy while reducing the associated systemic toxicity.

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            Lead Product(s): Motixafortide,Pembrolizumab,Irinotecan

            Therapeutic Area: Oncology Product Name: BL-8040

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 16, 2020

            Details:

            The results of the study showed substantial improvement as compared to historical results across all study endpoints. BioLineRx plans to present the full data set at an upcoming medical conference.

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            Lead Product(s): Aspacytarabine

            Therapeutic Area: Oncology Product Name: BST-236

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Israel Biotech Fund

            Deal Size: $46.0 million Upfront Cash: Undisclosed

            Deal Type: Series C Financing December 02, 2020

            Details:

            These additional proceeds will be used to advance the clinical development of Biosight’s lead asset BST-236 (aspacytarabine), currently being investigated in a multi-center Phase 2b study in the U.S.

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            Lead Product(s): Aspacytarabine

            Therapeutic Area: Oncology Product Name: BST-236

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 05, 2020

            Details:

            The presentation will present updated clinical data from the Company’s ongoing Phase 2b trial evaluating aspacytarabine (BST-236) as a single-agent first-line AML therapy for patients unfit for standard chemotherapy.

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            Lead Product(s): Motixafortide,Cemiplimab,Gemcitabine Hydrochloride

            Therapeutic Area: Oncology Product Name: BL-8040

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 29, 2020

            Details:

            Company's lead drug candidate, the CXCR4-inhibitor Motixafortide, will be tested in combination with the anti-PD-1 cemiplimab (LIBTAYO®) and standard-of-care chemotherapy (gemcitabine and nab-paclitaxel) in first-line metastatic pancreatic ductal adenocarcinoma (PDAC).

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            Lead Product(s): Ofranergene obadenovec,Nivolumab

            Therapeutic Area: Oncology Product Name: VB-111

            Highest Development Status: Phase II Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Bristol-Myers Squibb

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 10, 2020

            Details:

            First two patients have been enrolled in the Phase 2 clinical trial of VB-111 in combination with nivolumab (Opdivo®), an immune checkpoint inhibitor, for the treatment of metastatic colorectal cancer.

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            Lead Product(s): Aspacytarabine

            Therapeutic Area: Oncology Product Name: BST-236

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 04, 2020

            Details:

            BST-236, Biosight’s lead product candidate, is a novel antimetabolite, designed to provide the benefit of intensive chemotherapy while avoiding much of its toxicity.