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Lead Product(s): Camidanlumab Tesirine,Pembrolizumab
Therapeutic Area: Oncology Product Name: ADCT-301
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable November 03, 2020
Details:
First patient has been dosed with camidanlumab tesirine (Cami, formerly ADCT-301) in combination with pembrolizumab, a checkpoint inhibitor, in an ongoing Phase 1b clinical trial in patients with selected advanced solid tumors.
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Lead Product(s): Camidanlumab Tesirine
Therapeutic Area: Oncology Product Name: ADCT-301
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 17, 2020
Details:
The ongoing, multicenter, open-label Phase 1b clinical trial of camidanlumab tesirine (Cami, formerly ADCT-301) is enrolling patients with selected locally advanced or metastatic solid tumors.
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Lead Product(s): Minigastrin-Lu177
Therapeutic Area: Oncology Product Name: Debio 1124
Highest Development Status: Phase I Product Type: Peptide
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 26, 2020
Details:
First patient dosed in the multicenter, single-arm, open-label Phase 1 study assessing the safety, distribution, and dosing of Debio 1124 in patients with advanced, unresectable pulmonary and extrapulmonary small cell carcinoma.
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Lead Product(s): Emactuzumab
Therapeutic Area: Oncology Product Name: RG7155
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Celleron
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Licensing Agreement August 12, 2020
Details:
Roche to provid Celleron exclusive world-wide rights for the clinical development, manufacturing and commercialization of emactuzumab. Emactuzumab is a monoclonal antibody designed to target and deplete macrophages in the tumor tissue.
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Lead Product(s): RO7198457,Atezolizumab
Therapeutic Area: Oncology Product Name: RO7198457
Highest Development Status: Phase I Product Type: Vaccine
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable June 22, 2020
Details:
A phase 1b trial of a personalized cancer vaccine in development at Roche and BioNTech has chalked up a “low” response rate.
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Lead Product(s): Glofitamab
Therapeutic Area: Oncology Product Name: Undisclosed
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable June 12, 2020
Details:
Results from the phase I NP30179 study show durable complete responses with glofitamab in patients with aggressive and indolent lymphomas after a median of three prior lines of therapy.
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Lead Product(s): FAZ053
Therapeutic Area: Oncology Product Name: Undisclosed
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Laekna Therapeutics
Deal Size: Undisclosed Upfront Cash: Undisclosed
Deal Type: Licensing Agreement March 24, 2020
Details:
Laekna now has exclusive rights to develop and commercialize the PD-L1 oncology asset. With this move, the company aims to advance clinical research and introduce pioneering new drugs to patients.
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Lead Product(s): Debio 0123
Therapeutic Area: Oncology Product Name: Undisclosed
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable March 05, 2020
Details:
Debio 0123 starts first-in-human, dose escalation phase I clinical trial assessing the safety and efficacy of the compound in combination with carboplatin to treat refractory solid tumors.
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Lead Product(s): IOA-244
Therapeutic Area: Oncology Product Name: Undisclosed
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable February 26, 2020
Details:
The phase I study will enrol approximately 60 patients with solid tumours that overexpress PI3K? and are burdened by immune cells of the suppressor phenotype that are sensitive to PI3K? inhibition.
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Lead Product(s): IOA-244
Therapeutic Area: Oncology Product Name: Undisclosed
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: INKEF Capital
Deal Size: $16.5 million Upfront Cash: Undisclosed
Deal Type: Series A Financing January 23, 2020
Details:
iOnctura will use the proceeds of the Series A to move its lead molecule IOA-244, a highly selective PI3K?-inhibitor, into a Phase I trial in solid tumours and its second program, IOA-289, an ATX-inhibitor, through IND enabling studies.
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