Lead Product(s) : Enzomenib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : National Cancer Institute
Deal Size : Undisclosed
Deal Type : Agreement
Sumitomo Pharma America Enters into a CRADA with the National Cancer Institute
Details : The collaboration aims to evaluate DSP-5336 (enzomenib), an oral, small molecule designed to inhibit the menin and KMT2A protein interaction present in certain difficult to treat cancers.
Product Name : DSP-5336
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
April 14, 2025
Lead Product(s) : Enzomenib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : National Cancer Institute
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Radgocitabine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Delta-Fly Updates on DFP-10917, Venetoclax Combination Development Progress
Details : DFP-10917 (radgocitabine) is a DNA polymerase inhibitor small molecule, being evaluated in combination with venetoclax for the treatment of R/R acute myeloid leukemia.
Product Name : DFP-10917
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
February 28, 2025
Lead Product(s) : Radgocitabine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Radgocitabine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Delta-Fly Shows Initial Phase 1/2 Data for AML Combo Therapy
Details : DFP-10917 (radgocitabine) is a DNA polymerase inhibitor small molecule drug candidate which is being evaluated in combination with venetoclax for the treatment of acute myeloid leukemia.
Product Name : DFP-10917
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
October 28, 2024
Lead Product(s) : Radgocitabine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Radgocitabine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Delta-Fly Initiates Enrollment for Ph I/II Combo-Study of DFP-10917 and Venetoclax in AML
Details : DFP-10917 (radgocitabine) is a DNA polymerase inhibitor small molecule drug candidate which is being evaluated in combination with venetoclax for the treatment of acute myeloid leukemia.
Product Name : DFP-10917
Product Type : Cytotoxic Drug
Upfront Cash : Inapplicable
October 09, 2024
Lead Product(s) : Radgocitabine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Enzomenib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Sumitomo Pharma’s DSP-5336 Receives FDA Fast Track for Acute Myeloid Leukemia
Details : DSP-5336, an Investigational menin and mixed-lineage leukemia inhibitor, is being evaluated in patients with relapsed or refractory acute myeloid leukemia with a KMT2A rearrangement.
Product Name : DSP-5336
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 15, 2024
Lead Product(s) : Enzomenib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Selpercatinib
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Chugai Gets Approval for FoundationOne CDx as Companion Diagnostic for RET Inhibitor
Details : Retevmo (selpercatinib) is an oral RET receptor tyrosine kinase inhibitor, small molecule drug candidate which is indicated for the treatment of RET fusion-positive solid tumors.
Product Name : Retevmo
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
February 29, 2024
Lead Product(s) : Selpercatinib
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Gilteritinib Fumarate,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Clinical Trial Evaluates Triple-Drug Regimen for FLT3-Mutated AML
Details : Xospata (gilteritinib) is a receptor tyrosine kinase inhibitor being evaluated in combination with venetoclax and azacitidine for relapsed/refractory AML with an FLT3 mutation.
Product Name : Xospata
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 30, 2024
Lead Product(s) : Gilteritinib Fumarate,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Datopotamab Deruxtecan,Durvalumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : AstraZeneca
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Imfinzi (durvalumab) a PD-L1 inhibitor in combination with Dato-DXd (datopotamab deruxtecan) a TOP1 inhibitor is being evaluated in phase 1/2 clinical trials for the treatment of patients with metastatic triple-negative breast cancer.
Product Name : DS-1062a
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
October 22, 2023
Lead Product(s) : Datopotamab Deruxtecan,Durvalumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : AstraZeneca
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Datopotamab Deruxtecan,Durvalumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Dato-DXd (datopotamab deruxtecan) in combination with Imfinzi (durvalumab) is being evaluated in phase 1/2 clinical trials for the treatment of advanced or metastatic triple negative breast cancer.
Product Name : DS-1062a
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
October 22, 2023
Lead Product(s) : Datopotamab Deruxtecan,Durvalumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Ifinatamab Deruxtecan
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : I-DXd (ifinatamab deruxtecan) is a specifically engineered potential first-in-class B7-H3 directed antibody drug conjugate (ADC). It is under phase 1/2 clinical development for the treatment of advanced small cell lung cancer.
Product Name : I-DXd
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
October 09, 2023
Lead Product(s) : Ifinatamab Deruxtecan
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable