Drugs in Dev.
Oncology
IND Enabling
Switzerland 
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Lead Product(s) : OT-C001,Rituximab
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : EMERCell
Deal Size : Inapplicable
Deal Type : Inapplicable
Onward Therapeutics gets IMPD OK to Start Allogeneic NK Cell Study
Details : OT-C001 is an optimized cell therapy product consisting of highly activated & allogeneic NK cells. It is being evaluated for the treatment of relapsed/refractory diffuse large B-cell lymphoma.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
April 21, 2025
Lead Product(s) : OT-C001,Rituximab
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : EMERCell
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALE.P02
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Alentis Gains FDA Fast Track for ALE.P02 in CLDN1+ Squamous Solid Tumors
Details : ALE.P02 is a first-in-class ADC designed by linking a tubulin inhibitor, a potent cancer drug. It is being evaluated for the treatment of CLDN1+ squamous cancers.
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
November 18, 2024
Lead Product(s) : ALE.P02
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALE.P02
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : OrbiMed Advisors
Deal Size : $181.4 million
Deal Type : Series D Financing
Alentis Raises $181.4M To Advance Anti-Claudin-1 ADCs in Solid Tumors
Details : The financing will support the development of first-in-class CLDN1 targeted medicines including Phase 1/2 studies of ALE.P02 and ALE.P03, first-in-class ADCs designed by linking a potent cancer drug.
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Undisclosed
November 12, 2024
Lead Product(s) : ALE.P02
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : OrbiMed Advisors
Deal Size : $181.4 million
Deal Type : Series D Financing

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Lead Product(s) : ALE.P02
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Alentis Therapeutics Receives FDA IND Clearance For ALE.P02 For Squamous Cancers
Details : ALE.P02 is a first-in-class ADC designed by linking a tubulin inhibitor, a potent cancer drug. It is being evaluated for the treatment of squamous cancers.
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
October 02, 2024
Lead Product(s) : ALE.P02
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : BPT567
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Johnson & Johnson
Deal Size : $90.0 million
Deal Type : Series C Financing
Bright Peak Therapeutics Announces $90 Million in Series C Financing for PD1-IL18
Details : The proceeds from the Series C financing will be used to advance the Bright Peak Therapeutics lead product BPT567 into a clinical trial for the treatment of neoplasms.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
June 11, 2024
Lead Product(s) : BPT567
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Johnson & Johnson
Deal Size : $90.0 million
Deal Type : Series C Financing

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Lead Product(s) : ANV600,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Anaveon announces IND approval of ANV600-001 (EXPAND) Phase I/II clinical study
Details : Anaveon investigational product ANV600 monotherapy and combination with Keytruda as part of a multi-cohort study to evaluate the safety and efficacy of ANV600 in multiple cancer indications.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 29, 2024
Lead Product(s) : ANV600,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : CDR404
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
CDR-Life Receives FDA Clearance for IND of CDR404 for Solid Tumor Treatment
Details : CDR404 is a bispecific MAGE-A4 T-cell engager based on M-gager® technology, currently in preclinical studies for lung, bladder, and esophageal cancers.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
January 23, 2024
Lead Product(s) : CDR404
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ALE.C04
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ALE.C04 is a first-in-class monoclonal antibody developed to specifically target exposed CLDN1 on cancer cells. This investigational antibody is designed to treat patients with recurrent or metastatic, CLDN1-positive HNSCC.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
August 24, 2023
Lead Product(s) : ALE.C04
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : IOS-1002
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ImmunOs Therapeutics Receives Regulatory Approval for First-In-Human Trial of IOS-1002
Details : IOS-1002 is a first-in-class, multi-functional agent based on a naturally occurring human leukocyte antigen (HLA) that targets multiple immune checkpoints to activate both innate and adaptive immune cells, thereby leading to profound anti-tumor activity.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
January 17, 2023
Lead Product(s) : IOS-1002
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : ISB 2001
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : In vitro studies showed that ISB 2001 exhibited increased killing potency of tumor cells compared to all tested antibodies that are either currently approved therapeutics for multiple myeloma or being tested in ongoing clinical studies.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
May 09, 2022
Lead Product(s) : ISB 2001
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
