Drugs in Dev.
Oncology
IND Enabling
France 
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Sanofi
Deal Size : Undisclosed
Deal Type : Acquisition
Sanofi Completes Acquisition of Amunix
Details : The acquisition also provides access to Amunix Pro-XTEN, XPAT, and XPAC technology to deliver next generation Conditionally Activated Biologics. The technology platform is highly complementary to Sanofi’s existing R&D platforms.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
February 08, 2022
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Sanofi
Deal Size : Undisclosed
Deal Type : Acquisition
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Sanofi
Deal Size : $1,225.0 million
Deal Type : Acquisition
Details : Under the terms of the agreement, Sanofi will acquire Amunix with it's pipeline including it's lead candidate, AMX-818, a masked HER2-directed TCE, offers a strong strategic fit with Sanofi’s focus on developing potentially transformative cancer therap...
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : $1,000.0 million
December 21, 2021
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Sanofi
Deal Size : $1,225.0 million
Deal Type : Acquisition
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : AMX-818, a protease-activated T cell engager targeting HER2 with potent T Cell activation, proteolytic cleavage and efficacy in Xenograft tumors.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
October 07, 2021
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Data demonstrate potential of Amunix’s XPAT platform to significantly widen therapeutic index, and address on-target, off-tumor toxicity that has hindered application of T cell engagers to treat solid tumors.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
June 22, 2020
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Omega Funds
Deal Size : $73.0 million
Deal Type : Series A Financing
Amunix Raises $73 Million in Series A Financing Led by Omega Funds
Details : Amunix plans to utilize the Series A proceeds to advance its lead development candidate, AMX-818, to progress earlier discovery stage XPAT programs and to initiate XPAC discovery work.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
March 04, 2020
Lead Product(s) : AMX-818
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Omega Funds
Deal Size : $73.0 million
Deal Type : Series A Financing
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Lead Product(s) : IPH4502
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Innate Pharma Receives FDA Clearance for IND of IPH4502 in Solid Tumors
Details : IPH4502 is Innate’s novel and differentiated topoisomerase I inhibitor antibody-drug conjugate (ADC) targeting Nectin-4 to treat neoplasms.
Product Name : Undisclosed
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
September 23, 2024
Lead Product(s) : IPH4502
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : PFL-002
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Pierre Fabre: IND for PFL-002/VERT-002 in Solid Tumors with MET Mutations
Details : PFL-002/VERT-002 is a mAb developed by Vertical Bio, acting as a degrader of c-MET, in patients with solid tumors, including non-small cell lung cancer with mutations or amplification of MET.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
June 05, 2024
Lead Product(s) : PFL-002
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Onco-Boost
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Xista Science Ventures
Deal Size : $2.1 million
Deal Type : Financing
HEPHAISTOS-Pharma Raises €2 Million Seed Round with Xista Science Ventures and Others
Details : The proceeds will enable HEPHAISTOS to advance ONCO-Boost into clinical development for solid tumors, focusing on unmet needs like sarcoma.
Product Name : Onco-Boost
Product Type : Undisclosed
Upfront Cash : Undisclosed
January 23, 2024
Lead Product(s) : Onco-Boost
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Xista Science Ventures
Deal Size : $2.1 million
Deal Type : Financing

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Lead Product(s) : PFL-002
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Pierre Fabre
Deal Size : Undisclosed
Deal Type : Acquisition
Details : The acquisition allows Pierre to add VERT-002 to its oncology discovery pipeline. VERT-002 is a monoclonal antibody, acting as a degrader of c-MET. This target is a known disease driver in patients suffering from NSCLC with mutations or amplification of ...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
September 12, 2023
Lead Product(s) : PFL-002
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Pierre Fabre
Deal Size : Undisclosed
Deal Type : Acquisition

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Lead Product(s) : TG6050
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : TG6050 is an oncolytic virus developed with Transgene’s Invir.IO™ platform for intravenous administration. TG6050 has been engineered to encode human IL-12, a cytokine that triggers a powerful antitumor immune response and a full length antiCTLA4 ant...
Product Name : Undisclosed
Product Type : Microorganism
Upfront Cash : Inapplicable
January 06, 2023
Lead Product(s) : TG6050
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable



