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Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"CHINA","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"XW014","moa":"GLP-1 receptor","graph1":"Nutrition and Weight Loss","graph2":"Phase I","graph3":"Sciwind Biosciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Sciwind Biosciences \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Sciwind Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Ascletis Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"CHINA","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"ASC30","moa":"GLP-1 receptor","graph1":"Nutrition and Weight Loss","graph2":"Phase I","graph3":"Ascletis 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Pharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Ascletis Pharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Ascletis Pharma \/ Inapplicable"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : ASC30 is an investigational GLP-1R biased small molecule agonist and has unique and differentiated properties that enable the same small molecule for both oral tablet and subcutaneous injection.

                          Product Name : ASC30

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 22, 2025

                          Lead Product(s) : ASC30

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : ASC30 is an investigational small-molecule agonist biased toward GLP-1R. It is being evaluated as a once-daily oral tablet for the treatment of obesity.

                          Product Name : ASC30

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 31, 2025

                          Lead Product(s) : ASC30

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : ASC30 is an investigational small-molecule agonist biased toward GLP-1R. It is being evaluated as a once-daily oral tablet for the treatment of obesity.

                          Product Name : ASC30

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 19, 2025

                          Lead Product(s) : ASC30

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : ASC30 is the first and only small molecule GLP-1 receptor (GLP-1R) agonist that can be dosed once-monthly subcutaneously and once-daily orally for the treatment of obesity.

                          Product Name : ASC30

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 21, 2025

                          Lead Product(s) : ASC30

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : Under the licensing agreement, Sciwind has granted Verdiva the exclusive global rights to develop and commercialize the partnered programs, which includes XW004 (ecnoglutide) outside of greater China.

                          Product Name : XW004

                          Product Type : Peptide

                          Upfront Cash : $70.0 million

                          January 10, 2025

                          Lead Product(s) : Ecnoglutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Verdiva Bio

                          Deal Size : $2,470.0 million

                          Deal Type : Licensing Agreement

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                          06

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : ASC47 is an adipose-targeted thyroid hormone receptor beta (THRβ) selective small molecule agonist. It is being evaluated in combination with semaglutide for the treatment of obesity.

                          Product Name : ASC47

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 18, 2024

                          Lead Product(s) : ASC47,Semaglutide

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : The collaboration will accelerate the global development of LAE102, a novel Activin Receptor Type 2 A (ActRIIA) antagonistic monoclonal antibody (mAb) for muscle-preserving weight loss in Obesity.

                          Product Name : LAE102

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          November 20, 2024

                          Lead Product(s) : LAE102

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Eli Lilly

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : ASC30 is an investigational small-molecule agonist biased toward GLP-1R. It is being evaluated as a once-daily oral tablet for the treatment of obesity.

                          Product Name : ASC30

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 17, 2024

                          Lead Product(s) : ASC30

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : ASC47 is an adipose-targeted thyroid hormone receptor beta (THRβ) selective small molecule agonist. It is being evaluated for the treatment of obesity.

                          Product Name : ASC47

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 11, 2024

                          Lead Product(s) : ASC47

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : DR10624 is a novel FIC tri-specific biotherapeutic that specifically agonizing GLP-1R, glucagon receptor GCGR & FGF21R, it is being investigated for the treatment of obesity and hypertriglyceridemia.

                          Product Name : DR10624

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          May 07, 2024

                          Lead Product(s) : DR10624

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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