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            RPL554 (ensifentrine) is a selective, dual inhibitor of the enzymes phosphodiesterase 3 and 4 combining bronchodilator and NSAID activities in one compound. This activity has the potential to provide anti-inflammatory benefits for those with COPD.

            Lead Product(s): Ensifentrine

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: RPL554

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 10, 2023

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            Details:

            Ensifentrine is a selective, dual inhibitor of the enzymes phosphodiesterase 3 and 4 combining bronchodilator and NSAID activities in one compound. This activity has the potential to provide anti-inflammatory benefits for those with COPD.

            Lead Product(s): Ensifentrine

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: RPL554

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 06, 2023

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            AM-301, marketed as Bentrio™, is a drug-free nasal spray for personal protection against airborne viruses and allergens. Upon application into the nose, Bentrio™ forms a protective gel layer on the nasal mucosa.

            Lead Product(s): AM-301

            Therapeutic Area: Immunology Product Name: Bentrio

            Highest Development Status: Approved Product Type: Small molecule

            Recipient: Altamira Therapeutics

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 30, 2022

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            Under the cooperation agreement, DKSH HK will provide full-agency services including key account management, marketing promotion, supply chain, and distribution for Bentrio (bentonite) Nasal Spray sales operation in Hong Kong and Macau.

            Lead Product(s): Bentonite,Mono Propylene Glycol,Citric Acid

            Therapeutic Area: Immunology Product Name: Bentrio

            Highest Development Status: Approved Product Type: Small molecule

            Partner/Sponsor/Collaborator: DKSH

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership November 28, 2022

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            RPL554 (ensifentrine) met primary endpoint in ENHANCE-2 demonstrating a statistically significant and clinically meaningful improvement in lung function,significantly reduced the rate of COPD exacerbations in the ENHANCE-2 trial.

            Lead Product(s): Ensifentrine

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: RPL554

            Highest Development Status: Phase III Product Type: Small molecule

            Recipient: Verona Pharma

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 19, 2022

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            Details:

            Ensifentrine (RPL554) is an investigational, first-in-class, dual inhibitor of the enzymes phosphodiesterase 3 and 4 ("PDE3" and "PDE4") that combines bronchodilator and anti-inflammatory activities in one compound.

            Lead Product(s): Ensifentrine

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: RPL554

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Verona Pharma

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 18, 2022

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            Ketorolac (NTM-001) is a novel, alcohol-free formulation of ketorolac in a convenient, ready-to-use, pre-mixed bag for continuous 24 hours IV infusion, for the treatment of moderately severe acute pain requiring analgesia.

            Lead Product(s): Ketorolac Trometamol

            Therapeutic Area: Neurology Product Name: NTM-001

            Highest Development Status: Phase III Product Type: Small molecule

            Partner/Sponsor/Collaborator: Neumentum

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 26, 2022

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            The licensing agreement grants Nuance the exclusive rights to develop and commercialize AeroFact™, an innovate new therapy combining a well‐established pulmonary surfactant drug with proprietary vibrating mesh nebulizer aerosolization technology, in Greater China.

            Lead Product(s): AP-002

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: AeroFact

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Aerogen

            Deal Size: $212.5 million Upfront Cash: $20.0 million

            Deal Type: Licensing Agreement December 22, 2021

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            Details:

            Ensifentrine (RPL554) is an investigational, first-in-class, inhaled, dual inhibitor of the enzymes phosphodiesterase 3 and 4 (“PDE3” and “PDE4”). Verona Pharma has granted Nuance Pharma the exclusive rights to develop and commercialize ensifentrine in Greater China.

            Lead Product(s): Ensifentrine

            Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: RPL554

            Highest Development Status: Phase III Product Type: Small molecule

            Recipient: Verona Pharma

            Deal Size: $219.0 million Upfront Cash: $40.0 million

            Deal Type: Collaboration June 10, 2021

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            The license provides Nuance with exclusive rights to commercialize otenaproxesul in China, Hong Kong, Macau, and Taiwan, representing approximately 10% of the worldwide pharma market.

            Lead Product(s): Otenaproxesul

            Therapeutic Area: Neurology Product Name: ATB-346

            Highest Development Status: Phase II Product Type: Small molecule

            Recipient: Antibe Therapeutics

            Deal Size: $100.0 million Upfront Cash: $20.0 million

            Deal Type: Licensing Agreement February 09, 2021

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