[{"orgOrder":0,"company":"SciNeuro Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"SNP318","moa":"Lp-PLA2","graph1":"Neurology","graph2":"Phase I","graph3":"SciNeuro Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"SciNeuro Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"SciNeuro Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"SciNeuro Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"SNP318","moa":"Lp-PLA2","graph1":"Neurology","graph2":"Phase I","graph3":"SciNeuro Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"SciNeuro Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"SciNeuro Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Shanghai Zhimeng Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"CB03","moa":"KCNQ2\/3","graph1":"Neurology","graph2":"Phase I","graph3":"Shanghai Zhimeng Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Shanghai Zhimeng Biopharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Shanghai Zhimeng Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"SineuGene Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"SNUG01","moa":"TRIM72","graph1":"Neurology","graph2":"Phase I","graph3":"SineuGene Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intrathecal Infusion","sponsorNew":"SineuGene Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"SineuGene Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Guangzhou Fermion Technology","sponsor":"Jiangsu Simcere Pharmaceutical","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"CHINA","productType":"Other Small Molecule","year":"2025","type":"Agreement","leadProduct":"FZ002-037","moa":"SST4 receptor","graph1":"Neurology","graph2":"Phase I","graph3":"Guangzhou Fermion Technology","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Guangzhou Fermion Technology \/ Jiangsu Simcere Pharmaceutical","highestDevelopmentStatusID":"6","companyTruncated":"Guangzhou Fermion Technology \/ Jiangsu Simcere Pharmaceutical"},{"orgOrder":0,"company":"Shanghai Zhimeng Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"CB03","moa":"KCNQ2\/3","graph1":"Neurology","graph2":"Phase I","graph3":"Shanghai Zhimeng Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Shanghai Zhimeng Biopharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Shanghai Zhimeng Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Brise Pharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Other Large Molecule","year":"2023","type":"Inapplicable","leadProduct":"BR01T","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Brise Pharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Brise Pharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Brise Pharma \/ Inapplicable"},{"orgOrder":0,"company":"Brise Pharma","sponsor":"Shunxi Fund","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"CHINA","productType":"Other Large Molecule","year":"2024","type":"Series A Financing","leadProduct":"BR01T","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Brise Pharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Brise Pharma \/ Shunxi Fund","highestDevelopmentStatusID":"6","companyTruncated":"Brise Pharma \/ Shunxi Fund"},{"orgOrder":0,"company":"Shanghai SIMR Biotechnology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"SR419","moa":"Ion Channel","graph1":"Neurology","graph2":"Phase I","graph3":"Shanghai SIMR Biotechnology","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Suspension","sponsorNew":"Shanghai SIMR Biotechnology \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Shanghai SIMR Biotechnology \/ Inapplicable"},{"orgOrder":0,"company":"Ractigen Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Oligonucleotide","year":"2024","type":"Inapplicable","leadProduct":"RAG-17","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Ractigen Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intrathecal Injection","sponsorNew":"Ractigen Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Ractigen Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Ractigen Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Oligonucleotide","year":"2023","type":"Inapplicable","leadProduct":"RAG-17","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Ractigen Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intrathecal Injection","sponsorNew":"Ractigen Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Ractigen Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Ractigen Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Oligonucleotide","year":"2024","type":"Inapplicable","leadProduct":"RAG-17","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Ractigen Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intrathecal Injection","sponsorNew":"Ractigen Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Ractigen Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Ractigen Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"CHINA","productType":"Oligonucleotide","year":"2024","type":"Inapplicable","leadProduct":"RAG-17","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Ractigen Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Intrathecal Injection","sponsorNew":"Ractigen Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Ractigen Therapeutics \/ Inapplicable"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Top Deals by Deal Size (USD bn)

                          01

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : SNUG01 is a first-in-class TRIM72-targeted gene therapy, which is currently being evaluated for the treatment of amyotrophic lateral sclerosis.

                          Product Name : SNUG01

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          March 24, 2025

                          Lead Product(s) : SNUG01

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : Under the agreement, Simcere will gain exclusive rights to develop and commercialize FZ002-037 in Greater China. It is being evaluated for the treatment of Chronic Pain.

                          Product Name : FZ002-037

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 17, 2025

                          Lead Product(s) : FZ002-037

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Jiangsu Simcere Pharmaceutical

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          03

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : RAG-17 is a small interfering RNA (siRNA) targeting the Superoxide Dismutase 1 (SOD1) gene in the treatment of amyotrophic lateral sclerosis (ALS) associated with SOD1 mutations (ALS-SOD1).

                          Product Name : RAG-17

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          December 24, 2024

                          Lead Product(s) : RAG-17

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : RAG-17 is a small interfering RNA (siRNA) targeting the Superoxide Dismutase 1 (SOD1) gene in the treatment of amyotrophic lateral sclerosis (ALS) associated with SOD1 mutations (ALS-SOD1).

                          Product Name : RAG-17

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          October 09, 2024

                          Lead Product(s) : RAG-17

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : RAG-17 is a therapeutic siRNA specifically designed to suppress the SOD1 gene in Amyotrophic Lateral Sclerosis patients carrying the Superoxide Dismutase 1 (SOD1) mutation.

                          Product Name : RAG-17

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          May 15, 2024

                          Lead Product(s) : RAG-17

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : Proceeds will support the development of BR01T, an anti-TrkA antibody with potential to revolutionize chronic low back pain treatment, as the company advances its product pipeline.

                          Product Name : BR01T

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          April 22, 2024

                          Lead Product(s) : BR01T

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Shunxi Fund

                          Deal Size : $20.0 million

                          Deal Type : Series A Financing

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                          07

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : SNP318 is a small molecule, optimized for CNS penetrance, to induce broader anti-inflammatory benefits. It is being investigated as a novel Lp-PLA2 inhibitor targeting neurodegenerative and inflammatory diseases.

                          Product Name : SNP318

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 04, 2023

                          Lead Product(s) : SNP318

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : SNP318 is a small molecule oral inhibitor which works by targeting Lp-PLA2, it is currently being investigated for the treatment of Alzheimer Disease.

                          Product Name : SNP318

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 30, 2023

                          Lead Product(s) : SNP318

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : CB03 as a KCNQ2/3 potassium ion channel opener thus has its potential for become a safe and effective treatment option for ALS and other CNS diseases.

                          Product Name : CB03

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 20, 2023

                          Lead Product(s) : CB03

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          DIA 2025
                          Not Confirmed
                          DIA 2025
                          Not Confirmed

                          Details : BR01T, is a groundbreaking monoclonal antibody designed to target Tropomyosin Receptor Kinase (TrkA), which is investigated for addressing Chronic Low Back Pain (CLBP).

                          Product Name : BR01T

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          October 18, 2023

                          Lead Product(s) : BR01T

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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