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Liquid","sponsorNew":"Confo Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Confo Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Confo Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"BELGIUM","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"CFTX-1554","moa":"Angiotensin II type-2 receptor","graph1":"Neurology","graph2":"Phase I","graph3":"Confo Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Liquid","sponsorNew":"Confo Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Confo Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Confo Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"BELGIUM","productType":"Other Small 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Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Confo Therapeutics \/ Inapplicable"}]

Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          Top Deals by Deal Size (USD bn)

                          01

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : Under the terms of the agreement, Lilly will continue the clinical development program beyond Phase 1 of CFTX-1554, a novel inhibitor of the angiotensin II type 2 receptor (AT2R) for the treatment of neuropathic pain.

                          Product Name : CFTX-1554

                          Product Type : Other Small Molecule

                          Upfront Cash : $40.0 million

                          February 03, 2023

                          Lead Product(s) : CFTX-1554

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Eli Lilly

                          Deal Size : $630.0 million

                          Deal Type : Licensing Agreement

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                          02

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : CFTX-1554, a novel inhibitor of the angiotensin II type 2 receptor (AT2R), is being developed as a non-opioid approach to the treatment of neuropathic pain, while avoiding centrally mediated side effects, such as addiction and sedation.

                          Product Name : CFTX-1554

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 03, 2022

                          Lead Product(s) : CFTX-1554

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : CFTX-1554 is a novel inhibitor of AT2R, a clinically precedented target for the treatment of neuropathic pain. CFTX-1554 interacts more efficiently with the AT2R binding site, resulting in improved properties.

                          Product Name : CFTX-1554

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 15, 2022

                          Lead Product(s) : CFTX-1554

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : The grant will enable to further extend its current universal ConfoBody®, Cb35, toward other G proteins. The funds will also be used to identify additional universal ConfoBodies® for use in ConfoSensor® screening technology and lead neuropathic pain p...

                          Product Name : CFTX-1554

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 28, 2022

                          Lead Product(s) : CFTX-1554

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Flanders Innovation & Entrepreneurship

                          Deal Size : $1.8 million

                          Deal Type : Financing

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                          05

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : AbbVie has beefed up its neuro pipeline by acquiring Belgium-based Syndesi Therapeutics. This acquisition gives AbbVie access to Syndesi’s lead candidate SDI-118, a small molecule that is under evaluation to treat Alzheimer’s disease and major depres...

                          Product Name : SDI-118

                          Product Type : Other Small Molecule

                          Upfront Cash : $130.0 million

                          January 03, 2022

                          Lead Product(s) : SDI-118

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : AbbVie Inc

                          Deal Size : $1,000.0 million

                          Deal Type : Acquisition

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                          06

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : RES19-T has shown to produce an acute response, restoring calcium homeostasis and synaptic plasticity, aim to address the disease at its root and restore cognition in patients by reducing the cellular damage associated with memory loss.

                          Product Name : RES19-T

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 21, 2021

                          Lead Product(s) : RES19-T

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : NVD-001 is Novadip’s first generation autologous cell-based osteogenic (bone healing) product derived from the Company’s proprietary tissue regeneration platform. Study met its primary endpoint. NVD-001 showed a favorable safety profile over a two-ye...

                          Product Name : NVD-001

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          June 15, 2021

                          Lead Product(s) : NVD-001

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : Proceeds from the fundraise will allow completion of proof-of-concept clinical trials for both the Alzheimer’s and the diabetes programs. A first-in-human trial of RES19-T for Alzheimer’s was initiated in 2020.

                          Product Name : RES19-T

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 21, 2021

                          Lead Product(s) : RES19-T

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Korys Investments

                          Deal Size : $29.0 million

                          Deal Type : Series B Financing

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                          09

                          EPS
                          Not Confirmed
                          EPS
                          Not Confirmed

                          Details : RES19-T, a first-in-class small molecule, represents a novel approach to treat Alzheimer’s Disease (AD), aiming to address the disease at its root and restore cognition in patients by reducing the cellular damage associated with memory loss.

                          Product Name : RES19-T

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 12, 2020

                          Lead Product(s) : RES19-T

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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