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            Details:

            Under the terms of the agreement, Lilly will continue the clinical development program beyond Phase 1 of CFTX-1554, a novel inhibitor of the angiotensin II type 2 receptor (AT2R) for the treatment of neuropathic pain.

            Lead Product(s): CFTX-1554

            Therapeutic Area: Neurology Product Name: CFTX-1554

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Eli Lilly

            Deal Size: $630.0 million Upfront Cash: $40.0 million

            Deal Type: Licensing Agreement March 02, 2023

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            Details:

            CFTX-1554 is a novel inhibitor of AT2R, a clinically precedented target for the treatment of neuropathic pain. CFTX-1554 interacts more efficiently with the AT2R binding site, resulting in improved properties.

            Lead Product(s): CFTX-1554

            Therapeutic Area: Neurology Product Name: CFTX-1554

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 15, 2022

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            The grant will enable to further extend its current universal ConfoBody®, Cb35, toward other G proteins. The funds will also be used to identify additional universal ConfoBodies® for use in ConfoSensor® screening technology and lead neuropathic pain program, CFTX-1554.

            Lead Product(s): CFTX-1554

            Therapeutic Area: Neurology Product Name: CFTX-1554

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Flanders Innovation & Entrepreneurship

            Deal Size: $1.8 million Upfront Cash: Undisclosed

            Deal Type: Financing June 28, 2022

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            CFTX-1554, a novel inhibitor of the angiotensin II type 2 receptor (AT2R), is being developed as a non-opioid approach to the treatment of neuropathic pain, while avoiding centrally mediated side effects, such as addiction and sedation.

            Lead Product(s): CFTX-1554

            Therapeutic Area: Neurology Product Name: CFTX-1554

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 10, 2022

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            AbbVie has beefed up its neuro pipeline by acquiring Belgium-based Syndesi Therapeutics. This acquisition gives AbbVie access to Syndesi’s lead candidate SDI-118, a small molecule that is under evaluation to treat Alzheimer’s disease and major depressive disorder.

            Lead Product(s): SDI-118

            Therapeutic Area: Neurology Product Name: SDI-118

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: AbbVie Inc

            Deal Size: $1,000.0 million Upfront Cash: $130.0 million

            Deal Type: Acquisition March 01, 2022

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            RES19-T has shown to produce an acute response, restoring calcium homeostasis and synaptic plasticity, aim to address the disease at its root and restore cognition in patients by reducing the cellular damage associated with memory loss.

            Lead Product(s): RES19-T

            Therapeutic Area: Neurology Product Name: RES19-T

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 21, 2021

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            NVD-001 is Novadip’s first generation autologous cell-based osteogenic (bone healing) product derived from the Company’s proprietary tissue regeneration platform. Study met its primary endpoint. NVD-001 showed a favorable safety profile over a two-year observation period.

            Lead Product(s): NVD-001

            Therapeutic Area: Neurology Product Name: NVD-001

            Highest Development Status: Phase I Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 15, 2021

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            Proceeds from the fundraise will allow completion of proof-of-concept clinical trials for both the Alzheimer’s and the diabetes programs. A first-in-human trial of RES19-T for Alzheimer’s was initiated in 2020.

            Lead Product(s): RES19-T

            Therapeutic Area: Neurology Product Name: RES19-T

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Korys Investments

            Deal Size: $29.0 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing January 21, 2021

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            RES19-T, a first-in-class small molecule, represents a novel approach to treat Alzheimer’s Disease (AD), aiming to address the disease at its root and restore cognition in patients by reducing the cellular damage associated with memory loss.

            Lead Product(s): RES19-T

            Therapeutic Area: Neurology Product Name: RES19-T

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 03, 2020

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