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    [{"orgOrder":0,"company":"Algernon Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"CANADA","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Repirinast","moa":"antiasthmatics\/antiallergics (not acting primarily as antihistamines)","graph1":"Nephrology","graph2":"Preclinical","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Algernon Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Algernon Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Algernon Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"CANADA","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"Repirinast","moa":"antiasthmatics\/antiallergics (not acting primarily as antihistamines)","graph1":"Nephrology","graph2":"Preclinical","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Algernon Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Algernon Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Algernon Pharmaceuticals","sponsor":"Zhejiang Ausun Pharmaceutical","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"CANADA","productType":"Miscellaneous","year":"2022","type":"Agreement","leadProduct":"Repirinast","moa":"antiasthmatics\/antiallergics (not acting primarily as antihistamines)","graph1":"Nephrology","graph2":"Preclinical","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Inhalation","sponsorNew":"Algernon Pharmaceuticals \/ Zhejiang Ausun Pharmaceutical","highestDevelopmentStatusID":"4","companyTruncated":"Algernon Pharmaceuticals \/ Zhejiang Ausun Pharmaceutical"},{"orgOrder":0,"company":"Xortx Therapeutics","sponsor":"Xortx Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"CANADA","productType":"Miscellaneous","year":"2025","type":"Acquisition","leadProduct":"VB4-P5","moa":"Undisclosed","graph1":"Nephrology","graph2":"Preclinical","graph3":"Xortx Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Xortx Therapeutics \/ Xortx Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"Xortx Therapeutics \/ Xortx Therapeutics"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            Xortx Therapeutics

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                            Xortx Therapeutics

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                            Lead Product(s) : VB4-P5

                            Therapeutic Area : Nephrology

                            Study Phase : Preclinical

                            Sponsor : Xortx Therapeutics

                            Deal Size : $3.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Xortx Acquires Renal Anti-Fibrotic Program from Vectus Biosystems

                            Details : Through the acquisition of VB4-P5, the deal aims to advance the treatment of gout.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            October 17, 2025

                            Lead Product(s) : VB4-P5

                            Therapeutic Area : Nephrology

                            Highest Development Status : Preclinical

                            Sponsor : Xortx Therapeutics

                            Deal Size : $3.0 million

                            Deal Type : Acquisition

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                            02

                            Algernon Pharmaceuticals

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                            Algernon Pharmaceuticals

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                            Lead Product(s) : Repirinast

                            Therapeutic Area : Nephrology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Algernon Pharmaceuticals Receives Notice of Allowance from the Japanese Patent Office for Repirinast and the T...

                            Details : NP-251 (repirinast), company’s lead candidate for the treatment of chronic kidney disease, binds to receptors on mast cell and prevents their degranulation. Repirinast originally developed by Mitsubishi was sold in Japan under the brand name Romet™ f...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 31, 2023

                            Lead Product(s) : Repirinast

                            Therapeutic Area : Nephrology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Aurinia Pharmaceuticals

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                            Lead Product(s) : Voclosporin,Mycophenolate Mofetil,Undisclosed

                            Therapeutic Area : Nephrology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aurinia Pharmaceuticals Announces New and Refined Method of Use Patent for LUPKYNIS® in the Treatment of Lupu...

                            Details : Lupkynis (voclosporin) is a calcineurin-inhibitor of calcineurin. The immunosuppressant activity results in inhibition of lymphocyte proliferation, T-cell cytokine production, and expression of T-cell activation surface antigens. Currently being develope...

                            Product Name : Lupkynis

                            Product Type : Peptide, Unconjugated

                            Upfront Cash : Inapplicable

                            April 11, 2023

                            Lead Product(s) : Voclosporin,Mycophenolate Mofetil,Undisclosed

                            Therapeutic Area : Nephrology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Aurinia Pharmaceuticals

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                            Aurinia Pharmaceuticals

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                            Lead Product(s) : Voclosporin,Mycophenolate Mofetil,Undisclosed

                            Therapeutic Area : Nephrology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aurinia Pharmaceuticals Announces Allowance of a New and Refined Method of Use Patent for Lupkynis® in the Tr...

                            Details : Lupkynis (voclosporin) is a calcineurin-inhibitor of calcineurin. The immunosuppressant activity results in inhibition of lymphocyte proliferation, T-cell cytokine production, and expression of T-cell activation surface antigens. Currently being develope...

                            Product Name : Lupkynis

                            Product Type : Peptide, Unconjugated

                            Upfront Cash : Inapplicable

                            January 24, 2023

                            Lead Product(s) : Voclosporin,Mycophenolate Mofetil,Undisclosed

                            Therapeutic Area : Nephrology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Algernon Pharmaceuticals

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                            Algernon Pharmaceuticals

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                            Lead Product(s) : Repirinast

                            Therapeutic Area : Nephrology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Algernon Pharmaceuticals Provides Update on its Planned Phase 1 Repirinast Chronic Kidney Disease Study

                            Details : In pre-clinical model of kidney fibrosis, NP-251 (repirinast) reduced fibrosis by 50% with statistical significance, showed improvement when given in combination with Telmisartan, which is BP lowering medication and is considered, standard of care treatm...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 11, 2022

                            Lead Product(s) : Repirinast

                            Therapeutic Area : Nephrology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Algernon Pharmaceuticals

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                            Algernon Pharmaceuticals

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                            Lead Product(s) : Repirinast

                            Therapeutic Area : Nephrology

                            Study Phase : Preclinical

                            Sponsor : Zhejiang Ausun Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Algernon Pharmaceuticals Begins Manufacturing of Repirinast and Launches New Chronic Kidney Disease Research P...

                            Details : Repirinast was originally developed by Mitsubishi Tanabe Pharma (“Mitsubishi”) and was sold and marketed in Japan under the brand name Romet™ for the treatment of asthma. Romet™ was marketed for over 25 years in Japan.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            February 23, 2022

                            Lead Product(s) : Repirinast

                            Therapeutic Area : Nephrology

                            Highest Development Status : Preclinical

                            Sponsor : Zhejiang Ausun Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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