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Group"},{"orgOrder":0,"company":"Merck Group","sponsor":"EMD Serono","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2020","type":"Inapplicable","leadProduct":"M6223","moa":"V-set and immunoglobulin domain-containing protein 9 (TIGIT)","graph1":"Oncology","graph2":"Phase I","graph3":"Merck Group","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Merck Group \/ Merck Group","highestDevelopmentStatusID":"6","companyTruncated":"Merck Group \/ Merck Group"},{"orgOrder":0,"company":"Merck Group","sponsor":"Proxygen","pharmaFlowCategory":"D","therapeuticArea":"Technology","country":"AUSTRIA","productType":"Undisclosed","year":"2022","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Technology","graph2":"Discovery Platform","graph3":"Merck 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Department of Health, Abu Dhabi","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"GERMANY","productType":"Undisclosed","year":"2024","type":"Partnership","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Undisclosed","graph3":"Merck Group","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Merck Group \/ The Department of Health, Abu Dhabi","highestDevelopmentStatusID":"1","companyTruncated":"Merck Group \/ The Department of Health, Abu Dhabi"},{"orgOrder":0,"company":"Merck Group","sponsor":"Artios Pharma Limited","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Undisclosed","year":"2020","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Merck 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Group","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Merck Group \/ Merck Group","highestDevelopmentStatusID":"2","companyTruncated":"Merck Group \/ Merck Group"},{"orgOrder":0,"company":"Merck Group","sponsor":"Caris Life Sciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Partnership","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Discovery Platform","graph3":"Merck Group","amount2":1.3999999999999999,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","amount2New":1.3999999999999999,"dosageForm":"Undisclosed","sponsorNew":"Merck Group \/ Merck Group","highestDevelopmentStatusID":"3","companyTruncated":"Merck Group \/ Merck Group"},{"orgOrder":0,"company":"Merck Group","sponsor":"Skyhawk Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Neurology","graph2":"Discovery Platform","graph3":"Merck Group","amount2":2,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Neurology","amount2New":2,"dosageForm":"Undisclosed","sponsorNew":"Merck Group \/ Merck Group","highestDevelopmentStatusID":"3","companyTruncated":"Merck Group \/ Merck Group"},{"orgOrder":0,"company":"Merck Group","sponsor":"Gene Therapy Research Institution","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2024","type":"Agreement","leadProduct":"Undisclosed","moa":"AADC","graph1":"Neurology","graph2":"Phase I\/ Phase II","graph3":"Merck Group","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Merck Group \/ Gene Therapy Research Institution","highestDevelopmentStatusID":"7","companyTruncated":"Merck Group \/ Gene Therapy Research Institution"}]

    Find Clinical Drug Pipeline Developments & Deals by Merck Group

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                            01

                            Merck Group

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Discovery Platform

                            Recipient : Skyhawk Therapeutics

                            Deal Size : $2,000.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Merck KGaa Swoops to $2b Neurological Disease Pact with Skyhawk

                            Details : The collaboration will focus on the discovery of novel RNA-targeting small molecules in select neurological indications with high unmet medical need.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            August 18, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Discovery Platform

                            Recipient : Skyhawk Therapeutics

                            Deal Size : $2,000.0 million

                            Deal Type : Collaboration

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                            02

                            Merck Group

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                            Lead Product(s) : Cetuximab

                            Therapeutic Area : Oncology

                            Study Phase : Phase IV

                            Recipient : Gruppo Oncologico del Nord-Ovest

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Anti-EGFR Therapy in Right-sided Advanced Colorectal Cancer with WT RAS & High AREG/EREG

                            Details : Cetuximab is a Antibody drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Colorectal Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            July 31, 2025

                            Lead Product(s) : Cetuximab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase IV

                            Recipient : Gruppo Oncologico del Nord-Ovest

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Merck Group

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                            Lead Product(s) : Nirogacestat Hydrobromide

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Recipient : SpringWorks Therapeutics

                            Deal Size : $3,900.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Merck Completes Acquisition of SpringWorks Therapeutics

                            Details : Through the acquisition, Merck will leverage SpringWorks’ oncology portfolio, including Ogsiveo (Nirogacestat HBr). It is being indicated for adult patients with progressing desmoid tumors.

                            Product Name : Ogsiveo

                            Product Type : Miscellaneous

                            Upfront Cash : $3,900.0 million

                            July 01, 2025

                            Lead Product(s) : Nirogacestat Hydrobromide

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Recipient : SpringWorks Therapeutics

                            Deal Size : $3,900.0 million

                            Deal Type : Acquisition

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                            04

                            Merck Group

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                            Lead Product(s) : Nirogacestat Hydrobromide

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Recipient : SpringWorks Therapeutics

                            Deal Size : $3,900.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Merck KGaA in $3.9 Billion Deal to Buy US bIotech Firm SpringWorks

                            Details : Through the acquisition, Merck will leverage SpringWorks’ oncology portfolio, including Ogsiveo (Nirogacestat HBr). It is being indicated for adult patients with progressing desmoid tumors.

                            Product Name : Ogsiveo

                            Product Type : Miscellaneous

                            Upfront Cash : $3900 million

                            April 28, 2025

                            Lead Product(s) : Nirogacestat Hydrobromide

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Recipient : SpringWorks Therapeutics

                            Deal Size : $3,900.0 million

                            Deal Type : Acquisition

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                            05

                            Merck Group

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                            Lead Product(s) : Methotrexate

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : American University of Beirut Medical Center

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Tetra-modality Bladder Preservation Strategies in Muscle-invasive Bladder Cancer: TURBT+ Chemo/Immunotherapy+ ...

                            Details : Methotrexate is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Urinary Bladder Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Cytotoxic Drug

                            Upfront Cash : Inapplicable

                            November 13, 2024

                            Lead Product(s) : Methotrexate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : American University of Beirut Medical Center

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Merck Group

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                            Lead Product(s) : BND-35,Cetuximab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : Biond Biologics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Biond Biologics And Merck Partner on BND-35 Trial for Solid Tumors

                            Details : The collaboration aims to evaluate BND-35 in combination with Merck's anti-EGFR monoclonal antibody Erbitux (cetuximab) in a Phase 1 for unresectable or metastatic solid tumors.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            October 29, 2024

                            Lead Product(s) : BND-35,Cetuximab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : Biond Biologics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

                            Merck Group

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                            Lead Product(s) : Moxifloxacin

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Merck Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants

                            Details : Moxifloxacin is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 19, 2024

                            Lead Product(s) : Moxifloxacin

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Merck Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Merck Group

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                            Merck Group

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Gene Therapy Research Institution

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Merck Signs MoU with Gene Therapy Research Institution for Viral Vector-based Gene Therapy

                            Details : GTRI will utilize Merck’s Sf-RVN Insect Cell Line platform for the Good Manufacturing Practices (GMP) production of its viral vector-based gene therapy for Parkinson’s Disease.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Undisclosed

                            July 11, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Gene Therapy Research Institution

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            09

                            Merck Group

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Discovery Platform

                            Recipient : Biolojic Design

                            Deal Size : $376.3 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Biolojic, Merck KGaA Multi-Target Drug Discovery Collaboration

                            Details : The collaboration will leverage Biolojic Design’s AI-driven discovery platform to design therapeutic antibodies for the treatment of cancer and immunological disorders.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            June 03, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery Platform

                            Recipient : Biolojic Design

                            Deal Size : $376.3 million

                            Deal Type : Collaboration

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                            10

                            Merck Group

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                            Lead Product(s) : Tuvusertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Recipient : EMD Serono

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC ...

                            Details : Tuvusertib is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Ovarian Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 29, 2024

                            Lead Product(s) : Tuvusertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Recipient : EMD Serono

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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