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    [{"orgOrder":0,"company":"MeiraGTx","sponsor":"Johnson & Johnson Innovative Medicine","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2023","type":"Agreement","leadProduct":"Botaretigene Sparoparvovec","moa":"||GTPase","graph1":"Genetic Disease","graph2":"Phase III","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Subretinal Injection","sponsorNew":"MeiraGTx \/ Johnson & Johnson Innovative Medicine","highestDevelopmentStatusID":"10","companyTruncated":"MeiraGTx \/ Johnson & Johnson Innovative Medicine"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Johnson & Johnson Innovative Medicine","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Inapplicable","leadProduct":"Botaretigene Sparoparvovec","moa":"||GTPase","graph1":"Genetic Disease","graph2":"Phase I\/ Phase II","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Subretinal Injection","sponsorNew":"MeiraGTx \/ MeiraGTx","highestDevelopmentStatusID":"7","companyTruncated":"MeiraGTx \/ MeiraGTx"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2020","type":"Inapplicable","leadProduct":"Botaretigene Sparoparvovec","moa":"||GTPase","graph1":"Genetic Disease","graph2":"Phase III","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Subretinal Injection","sponsorNew":"MeiraGTx \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"MeiraGTx \/ Inapplicable"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"Botaretigene Sparoparvovec","moa":"||GTPase","graph1":"Genetic Disease","graph2":"Phase III","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Subretinal Injection","sponsorNew":"MeiraGTx \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"MeiraGTx \/ Inapplicable"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Hologen","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Collaboration","leadProduct":"AAV-GAD","moa":"||Undisclosed","graph1":"Neurology","graph2":"Phase II","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"MeiraGTx \/ Hologen","highestDevelopmentStatusID":"8","companyTruncated":"MeiraGTx \/ Hologen"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dental and Oral Health","country":"U.S.A","productType":"Undisclosed","year":"2023","type":"Inapplicable","leadProduct":"AAV2-hAQP1","moa":"||Undisclosed","graph1":"Dental and Oral Health","graph2":"Phase II","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MeiraGTx \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"MeiraGTx \/ Inapplicable"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dental and Oral Health","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Inapplicable","leadProduct":"AAV2-hAQP1","moa":"||Undisclosed","graph1":"Dental and Oral Health","graph2":"Phase II","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MeiraGTx \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"MeiraGTx \/ Inapplicable"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2022","type":"Inapplicable","leadProduct":"Aav-Gad","moa":"||Glutamic acid decarboxylase 1 (GAD1)","graph1":"Neurology","graph2":"Phase II","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"MeiraGTx \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"MeiraGTx \/ Inapplicable"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2023","type":"Inapplicable","leadProduct":"Aav-Gad","moa":"||Glutamic acid decarboxylase 1 (GAD1)","graph1":"Neurology","graph2":"Phase II","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"MeiraGTx \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"MeiraGTx \/ Inapplicable"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2024","type":"Inapplicable","leadProduct":"AAV-GAD","moa":"||Undisclosed","graph1":"Neurology","graph2":"Phase II","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"MeiraGTx \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"MeiraGTx \/ Inapplicable"},{"orgOrder":0,"company":"MeiraGTx","sponsor":"Sanofi","pharmaFlowCategory":"D","therapeuticArea":"Dental and Oral Health","country":"U.S.A","productType":"Other Large Molecule","year":"2023","type":"Financing","leadProduct":"AAV-AQP1","moa":"||Undisclosed","graph1":"Dental and Oral Health","graph2":"Phase I\/ Phase II","graph3":"MeiraGTx","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Dental & Oral Health","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MeiraGTx \/ Sanofi","highestDevelopmentStatusID":"7","companyTruncated":"MeiraGTx \/ Sanofi"}]

    Find Clinical Drug Pipeline Developments & Deals by MeiraGTx

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                            01

                            MeiraGTx

                            U.S.A arrow
                            EPSC
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                            MeiraGTx

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                            Lead Product(s) : AAV-GAD,Inapplicable

                            Therapeutic Area : Neurology

                            Study Phase : Phase II

                            Sponsor : Hologen

                            Deal Size : $430.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Hologen AI commits $430M to MeiraGTx Parkinson's gene therapy

                            Details : The collaboration aims to advance the clinical development of AAV-GAD, which is being evaluated in the mid-stage clinical trial studies for the treatment of Parkinson’s disease.

                            Product Name : AAV-GAD

                            Product Type : Cell and Gene therapy

                            Upfront Cash : $200.0 million

                            March 17, 2025

                            Lead Product(s) : AAV-GAD,Inapplicable

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II

                            Sponsor : Hologen

                            Deal Size : $430.0 million

                            Deal Type : Collaboration

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                            02

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : AAV-GAD,Inapplicable

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            MeiraGTx Gene Therapy Improves Motor Function in Phase 2 Parkinson’s Trial

                            Details : AAV-GAD is a gene therapy for Parkinson's disease. It delivers the glutamic acid decarboxylase (GAD) gene to the subthalamic nucleus, to increase production of the inhibitory neurotransmitter GABA.

                            Product Name : AAV-GAD

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            October 15, 2024

                            Lead Product(s) : AAV-GAD,Inapplicable

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

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                            EPSC
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                            Lead Product(s) : AAV2-hAQP1,Inapplicable

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Long-term Follow-up of Gene Therapy for Radiation-Induced Xerostomia

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            August 09, 2024

                            Lead Product(s) : AAV2-hAQP1,Inapplicable

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Botaretigene Sparoparvovec,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Johnson & Johnson Innovative Medicine

                            Deal Size : $415.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            MeiraGTx Announces Asset Purchase Agreement Involving its AAV-RPGR Collaboration for up to $415 million

                            Details : Under the agreement, Janssen gains the remaining interests in investigational gene therapy AAV5-RPGR (botaretigene sparoparvovec) for the treatment of X-linked retinitis pigmentosa.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : $350.0 million

                            December 21, 2023

                            Lead Product(s) : Botaretigene Sparoparvovec,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Johnson & Johnson Innovative Medicine

                            Deal Size : $415.0 million

                            Deal Type : Agreement

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                            05

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : AAV-AQP1,Inapplicable

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase I/ Phase II

                            Sponsor : Sanofi

                            Deal Size : $30.0 million

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            MeiraGTx Announces $30 Million Strategic Investment from Sanofi; Company Pursuing Multiple Additional Strategi...

                            Details : Sanofi will receive a right of first negotiation for the use of MeiraGTx’s Riboswitch gene regulation technology for certain Immunology and Inflammation and CNS targets, including AAV-AQP1, a gene therapy for xerostomia caused by Sjogren's syndrome.

                            Product Name : Undisclosed

                            Product Type : Other Large Molecule

                            Upfront Cash : Undisclosed

                            October 30, 2023

                            Lead Product(s) : AAV-AQP1,Inapplicable

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Sanofi

                            Deal Size : $30.0 million

                            Deal Type : Financing

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                            06

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : AAV2-hAQP1,Inapplicable

                            Therapeutic Area : Dental and Oral Health

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            July 03, 2023

                            Lead Product(s) : AAV2-hAQP1,Inapplicable

                            Therapeutic Area : Dental and Oral Health

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Aav-Gad,Inapplicable

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            June 08, 2023

                            Lead Product(s) : Aav-Gad,Inapplicable

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Aav-Gad,Inapplicable

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Double-blind Study to Evaluate the Safety of Glutamic Acid Decarboxylase Gene Transfer in Parkinson's Partic...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            November 02, 2022

                            Lead Product(s) : Aav-Gad,Inapplicable

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Botaretigene Sparoparvovec,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Late-Breaking Phase 1/2 Data Demonstrates Safety Profile of Investigational Gene Therapy Botaretigene Sparopar...

                            Details : Treatment with botaretigene sparoparvovec was found to have an acceptable safety profile and efficacy assessments in this proof-of-concept study demonstrated improvements in retinal sensitivity, visual function and functional vision.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 10, 2022

                            Lead Product(s) : Botaretigene Sparoparvovec,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            MeiraGTx

                            U.S.A arrow
                            EPSC
                            Not Confirmed
                            • fda
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                            Lead Product(s) : Botaretigene Sparoparvovec,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I/ Phase II

                            Recipient : Johnson & Johnson Innovative Medicine

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Janssen's RPGR Gene Therapy Shows Statistically Significant and Continued Vision Improvement in Patients with ...

                            Details : One-year findings support advancement into Phase 3 and include significant functional vision improvements observed in the time taken to walk through a vision-guided mobility maze at nine months.

                            Product Name : AAV-RPGR

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            November 13, 2020

                            Lead Product(s) : Botaretigene Sparoparvovec,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I/ Phase II

                            Recipient : Johnson & Johnson Innovative Medicine

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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