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            Details:

            The collaboration includes co-development and co-commercialization agreement for Foghorn’s selective BRM oncology program and undisclosed oncology target. The collaboration includes three additional discovery programs using Foghorn’s proprietary Gene Traffic Control platform.

            Lead Product(s): Undisclosed

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Discovery Platform Product Type: Small molecule

            Recipient: Foghorn Therapeutics

            Deal Size: $380.0 million Upfront Cash: $300.0 million

            Deal Type: Collaboration December 13, 2021

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            Details:

            First-time data from the Phase I/II LIBRETTO-001 trial of Retevmo (selpercatinib) treatment showed promising antitumour activity and safety in various RET fusion-positive advanced solid tumours. Safety consistent with known profile of Retevmo.

            Lead Product(s): Selpercatinib

            Therapeutic Area: Oncology Product Name: Retevmo

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Recipient: Eli Lilly

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 11, 2021

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            In the 121 efficacy-evaluable BTK-pretreated patients, the ORR was 62%. This deepening of response over time is consistent with other BTK inhibitors and suggests the overall efficacy profile of LOXO-305 will continue to strengthen with additional follow-up.

            Lead Product(s): Loxo-305

            Therapeutic Area: Oncology Product Name: LOXO-305

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Eli Lilly

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 07, 2020

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            LOXO-305 oral presentations will provide updated data from the ongoing Phase 1/2 BRUIN clinical trial in previously treated chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma, Waldenström's macroglobulinemia, and other non-Hodgkin lymphomas.

            Lead Product(s): Loxo-305,Venetoclax,Rituximab

            Therapeutic Area: Oncology Product Name: LOXO-305

            Highest Development Status: Phase I/ Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 05, 2020

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