Eli Lilly has succeeded in its attempt to get the first non-covalent version of Bruton’s tyrosine kinase, or BTK, inhibitors to market, pushing it past rival Merck.
NEW ORLEANS — Following up on two subsets presented Saturday, Eli Lilly’s Loxo Oncology fleshed out the data on its non-covalent BTK inhibitor pirtobrutinib in patients with mantle cell lymphomas as an FDA decision looms on whether the daily pill can enter a field covered by three BTK rivals.
INDIANAPOLIS and CAMBRIDGE, Mass., Dec. 13, 2021 /PRNewswire/ -- Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Foghorn Therapeutics Inc. (Nasdaq: FHTX), today announced a strategic collaboration to create novel oncology medicines by applying Foghorn's proprietary Gene Traffic Control® platform. The collaboration includes a co-development and co-commercialization agreement for Foghorn's selective BRM oncology program and an additional undisclosed oncology target. In addition, the collaboration includes three additional discovery programs using Foghorn's proprietary Gene Traffic Control platform.
 Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), and Kumquat Biosciences today announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses.
INDIANAPOLIS, March 5, 2021 /PRNewswire/ -- Loxo Oncology at Lilly, a research and development group of Eli Lilly and Company (NYSE: LLY), today announced that The Lancet has published data from the pirtobrutinib (previously referred to as LOXO-305) global Phase 1/2 BRUIN clinical trial in relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL), and other non-Hodgkin's lymphomas. Pirtobrutinib is an investigational, highly selective, non-covalent Bruton's tyrosine kinase (BTK) inhibitor.
Eli Lilly’s cancer R&D chief Josh Bilenker, M.D., is hitting the exit. His departure comes two years after the Big Pharma ponied up $8 billion for Bilenker’s startup, Loxo Oncology, and one year after it combined the oncology team at Lilly Research Laboratories with the Loxo team—and put Bilenker and two other Loxo executives in charge.
Josh Bilenker’s abrupt exit from the top job at Loxo Oncology at Lilly on Friday came as a surprise to many. But then everything about the Loxo approach has been surprising, starting with the decision by Eli Lilly’s top execs in late 2019 to put the biotech team brought in through an $8 billion buyout in charge of oncology research.
A little more than a year since Josh Bilenker started an unusual experiment running Eli Lilly’s cancer research group following the $8 billion sale of his startup Loxo to the pharma giant, the biotech entrepreneur is wrapping up his part in the venture.
Eli Lilly's oncology division, Loxo Oncology at Lilly, has struck a deal with Merus NV to co-develop up to three bispecific antibody drugs for cancer.