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    [{"orgOrder":0,"company":"Landos Biopharma","sponsor":"LianBio","pharmaFlowCategory":"D","amount":"$218.0 million","upfrontCash":"$18.0 million","newsHeadline":"Landos Biopharma and LianBio Announce Exclusive Collaboration and License Agreement for Omilancor and NX-13","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"May 2021","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Phase II"},{"orgOrder":0,"company":"Landos Biopharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Landos Phase 2 Data of Omilancor in Ulcerative Colitisr Oral Presentation","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"July 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Phase 3-Ready Clinical Candidate Omilancor for the Treatment of Ulcerative Colitis and Crohn\u2019s Disease","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"March 2023","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Phase II"},{"orgOrder":0,"company":"Landos Biopharma","sponsor":"KU Leuven","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Landos Biopharma Announces Strategic Research Collaboration with KU Leuven and University Hospitals Leuven to Further Characterize the Effects of NX-13 on Epithelial Cells","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"September 2023","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Phase II"},{"orgOrder":0,"company":"Landos Biopharma","sponsor":"AbbVie Inc","pharmaFlowCategory":"D","amount":"$212.5 million","upfrontCash":"$137.5 million","newsHeadline":"AbbVie to Acquire Landos Biopharma, Further Strengthening its Portfolio in Inflammatory and Autoimmune Diseases","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"March 2024","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Phase II"}]

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              Landos Biopharma

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              AbbVie to Acquire Landos Biopharma, Further Strengthening its Portfolio in Inflammatory and Autoimmune Diseases

              Details:

              Through the acquisition, AbbVie will advance Landos’ lead investigational asset is NX-13, a first-in-class, oral NLRX1 agonist (a member of the NOD-like receptor family) with a bimodal mechanism of action, which is anti-inflammatory and facilitates epithelial repair.

              Lead Product(s): NX-13

              Therapeutic Area: Gastroenterology Product Name: NX-13

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: AbbVie Inc

              Deal Size: $212.5 million Upfront Cash: $137.5 million

              Deal Type: Acquisition March 25, 2024

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              Landos Biopharma

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              Landos Biopharma Announces Strategic Research Collaboration with KU Leuven and University Hospitals Leuven to Further Characterize the Effects of NX-13 on Epithelial Cells

              Details:

              The collaboration aims to investigate the effects of NX-13, first-in-class, oral, gut-selective, NLRX1 agonist, on epithelial cells with the Inflammatory Bowel Disease.

              Lead Product(s): NX-13

              Therapeutic Area: Gastroenterology Product Name: NX-13

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: KU Leuven

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Collaboration September 14, 2023

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              Josep Bassaganya-Riera Launches NImmune Biopharma with Phase 3-Ready Clinical Candidate Omilancor for the Treatment of Ulcerative Colitis and Crohn’s Disease

              Details:

              BT-11 (omilancor) is a novel, oral, gut-restricted therapeutic targeting the lanthionine synthetase C-like 2 (LANCL2) pathway which decreases the production of key inflammatory mediators causing ulcerative colitis.

              Lead Product(s): Omilancor

              Therapeutic Area: Gastroenterology Product Name: BT-11

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: NImmune Biopharma

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 22, 2023

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              Landos Biopharma Announces Acceptance of Abstract on NX-13 Phase 1b Study in Ulcerative Colitis at 18th Annual Congress of the European Crohn's and Colitis Organization

              Details:

              NX-13 is a first-in-class novel, gut-selective oral therapeutic candidate that targets NLRX1 that has been associated with the modulation of inflammatory cytokines for UC and CD.

              Lead Product(s): NX-13

              Therapeutic Area: Gastroenterology Product Name: NX-13

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 11, 2023

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              Landos Biopharma Announces $16.7 Million Private Placement Financing

              Details:

              Landos Biopharma anticipates using the net proceeds from the investment to advance the development of NX-13 for Ulcerative Colitis and Crohn’s Disease and for other general corporate purposes.

              Lead Product(s): NX-13

              Therapeutic Area: Gastroenterology Product Name: NX-13

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Undisclosed

              Deal Size: $16.7 million Upfront Cash: Undisclosed

              Deal Type: Private Placement January 05, 2023

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              Landos Biopharma Reports Positive Top-Line Results From NX-13 Phase 1b Trial

              Details:

              NX-13 is a novel, gut-restricted, orally active, small molecule therapeutic candidate for the treatment of UC. NX-13 targets NLRX1, a mitochondria-associated receptor with the ability to modulate immune responses.

              Lead Product(s): NX-13

              Therapeutic Area: Gastroenterology Product Name: NX-13

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 03, 2022

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              Landos Biopharma to Collaborate on a Phase 2 Study of Omilancor in Crohn’s Disease with the Icahn School of Medicine at Mount Sinai

              Details:

              Landos Biopharma collaborate with Icahn School of Medicine to conduct a Phase 2 trial of omilancor, a novel, oral, gut-restricted, small-molecule investigational drug that targets the Lanthionine Synthetase C-Like 2 (LANCL2) pathway impacting the gastrointestinal tract.

              Lead Product(s): Omilancor

              Therapeutic Area: Gastroenterology Product Name: BT-11

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Icahn School of Medicine

              Deal Size: $3.0 million Upfront Cash: Undisclosed

              Deal Type: Collaboration September 20, 2021

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              Landos Biopharma to Present Results of LABP-104 in Lupus at the American College of Rheumatology Convergence 2021

              Details:

              Oral treatment with LABP-104 in preclinical models of Systemic Lupus Erythematosus (SLE) resulted in enhanced Treg function, decreased kidney inflammation and reduced interferon gamma signaling.

              Lead Product(s): LABP-104

              Therapeutic Area: Immunology Product Name: LABP-104

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable September 15, 2021

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              Landos Phase 2 Data of Omilancor in Ulcerative Colitisr Oral Presentation

              Details:

              Discovered using Landos proprietary LANCE® Advanced A.I. platform, omilancor is a novel, oral, gut-restricted small molecule investigational drug that targets the Lanthionine Synthetase C-Like 2 (LANCL2) pathway impacting the gastrointestinal tract.

              Lead Product(s): Omilancor

              Therapeutic Area: Gastroenterology Product Name: BT-11

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable July 22, 2021

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              Landos Biopharma and LianBio Announce Exclusive Collaboration and License Agreement for Omilancor and NX-13

              Details:

              LianBio will receive exclusive rights to develop and commercialize BT-11 and NX-13 in Greater China, South Korea, Singapore, Thailand, Vietnam, Myanmar, Cambodia, Indonesia, and the Philippines.

              Lead Product(s): Omilancor

              Therapeutic Area: Gastroenterology Product Name: BT-11

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: LianBio

              Deal Size: $218.0 million Upfront Cash: $18.0 million

              Deal Type: Collaboration May 17, 2021

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