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    [{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"Spruce Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Partnership","leadProduct":"Tildacerfont","moa":"CRHR1","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Kaken Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"8","companyTruncated":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"Whitehawk Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibiotic","year":"2025","type":"Divestment","leadProduct":"Sirolimus","moa":"FK506-binding protein 1A||mTOR","graph1":"Oncology","graph2":"Approved FDF","graph3":"Kaken 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Disease","amount2New":0.02,"dosageForm":"Tablet","sponsorNew":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"15","companyTruncated":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"Fresh Tracks Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"JAPAN","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Sofpironium Bromide","moa":"Muscarinic acetylcholine receptor","graph1":"Dermatology","graph2":"Approved FDF","graph3":"Kaken Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Gel","sponsorNew":"Kaken Pharmaceuticals \/ Fresh Tracks Therapeutics","highestDevelopmentStatusID":"15","companyTruncated":"Kaken Pharmaceuticals \/ Fresh Tracks Therapeutics"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"Fresh Tracks Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Sofpironium Bromide","moa":"Muscarinic acetylcholine receptor","graph1":"Dermatology","graph2":"Phase III","graph3":"Kaken Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Gel","sponsorNew":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"Astria Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Licensing Agreement","leadProduct":"Navenibart","moa":"Plasma kallikrein","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Kaken Pharmaceuticals","amount2":0.029999999999999999,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0.029999999999999999,"dosageForm":"Injection","sponsorNew":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"CymaBay Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Miscellaneous","year":"2023","type":"Collaboration","leadProduct":"Seladelpar Lysine","moa":"PPA-delta receptor","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Kaken Pharmaceuticals","amount2":0.16,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0.16,"dosageForm":"Capsule","sponsorNew":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"Johnson & Johnson","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"JAPAN","productType":"Miscellaneous","year":"2024","type":"Licensing Agreement","leadProduct":"KP-723","moa":"STAT6","graph1":"Dermatology","graph2":"Preclinical","graph3":"Kaken Pharmaceuticals","amount2":1.25,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Dermatology","amount2New":1.25,"dosageForm":"Undisclosed","sponsorNew":"Kaken Pharmaceuticals \/ Johnson & Johnson","highestDevelopmentStatusID":"4","companyTruncated":"Kaken Pharmaceuticals \/ Johnson & Johnson"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"Alumis","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Collaboration","leadProduct":"ESK-001","moa":"TYK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Kaken Pharmaceuticals","amount2":0.17999999999999999,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0.17999999999999999,"dosageForm":"Tablet","sponsorNew":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"Numab Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"SWITZERLAND","productType":"Miscellaneous","year":"2024","type":"Collaboration","leadProduct":"ND081","moa":"Undisclosed","graph1":"Gastroenterology","graph2":"Preclinical","graph3":"Kaken Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"4","companyTruncated":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals"},{"orgOrder":0,"company":"Kaken Pharmaceuticals","sponsor":"bitBiome","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"JAPAN","productType":"Undisclosed","year":"2023","type":"Agreement","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Discovery","graph3":"Kaken Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"2","companyTruncated":"Kaken Pharmaceuticals \/ Kaken Pharmaceuticals"}]

    Find Clinical Drug Pipeline Developments & Deals by Kaken Pharmaceuticals

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                            01

                            Kaken Pharmaceuticals

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                            Aus. Peptide Conference
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                            Kaken Pharmaceuticals

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                            Lead Product(s) : Navenibart

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Recipient : Astria Therapeutics

                            Deal Size : $32.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Astria Enters into Licensing Agreement with Kaken to Develop Navenibart for HAE in Japan

                            Details : Under the licensing agreement, Kaken will hold the rights of STAR-0215 (navenibart) in Japan. It is being evaluated in the late-stage for the treatment of hereditary angioedema.

                            Product Name : STAR-0215

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : $16.0 million

                            August 06, 2025

                            Lead Product(s) : Navenibart

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Recipient : Astria Therapeutics

                            Deal Size : $32.0 million

                            Deal Type : Licensing Agreement

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                            02

                            Kaken Pharmaceuticals

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                            Lead Product(s) : Sebetralstat

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Recipient : KalVista Pharmaceuticals

                            Deal Size : $22.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            KalVista Licenses Sebetralstat to Kaken for HAE Market in Japan

                            Details : Under the licensing agreement, Kaken will holds the rights of KVD900 (sebetralstat) in Japan. It is being evaluated for the treatment of hereditary angioedema.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $11.0 million

                            April 08, 2025

                            Lead Product(s) : Sebetralstat

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Recipient : KalVista Pharmaceuticals

                            Deal Size : $22.0 million

                            Deal Type : Licensing Agreement

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                            03

                            Kaken Pharmaceuticals

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                            Aus. Peptide Conference
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                            Lead Product(s) : Sirolimus Protein-bound Particle,Sirolimus

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Recipient : Whitehawk Therapeutics

                            Deal Size : $100.0 million

                            Deal Type : Divestment

                            DEALS_DEV arrow-down

                            Whitehawk Finalizes Aadi Sale To Kaken In Strategic Transformation

                            Details : Through the divestment, Kaken assumes ownership of FYARRO (sirolimus protein-bound particles for injectable suspension) used to treat adults with malignant perivascular epithelioid cell tumor.

                            Product Name : Fyarro

                            Product Type : Antibiotic

                            Upfront Cash : $100.0 million

                            March 26, 2025

                            Lead Product(s) : Sirolimus Protein-bound Particle,Sirolimus

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Recipient : Whitehawk Therapeutics

                            Deal Size : $100.0 million

                            Deal Type : Divestment

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                            04

                            Kaken Pharmaceuticals

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                            Aus. Peptide Conference
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                            Kaken Pharmaceuticals

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                            Lead Product(s) : ESK-001

                            Therapeutic Area : Dermatology

                            Study Phase : Phase III

                            Recipient : Alumis

                            Deal Size : $180.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Alumis, Kaken Partner on ESK-001 for Dermatology in Japan

                            Details : The collaboration aims to develop, manufacture and commercialize ESK-001, a highly selective, next-gen oral TYK2 inhibitor, for dermatology indications in Japan.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $40.0 million

                            March 25, 2025

                            Lead Product(s) : ESK-001

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase III

                            Recipient : Alumis

                            Deal Size : $180.0 million

                            Deal Type : Collaboration

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                            05

                            Kaken Pharmaceuticals

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                            Aus. Peptide Conference
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                            Kaken Pharmaceuticals

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                            Lead Product(s) : KP-723

                            Therapeutic Area : Dermatology

                            Study Phase : Preclinical

                            Sponsor : Johnson & Johnson

                            Deal Size : $1,247.5 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Kaken, J&J Ink Potential $1.2B-Plus STAT6 Deal

                            Details : Johnson gains an exclusive license to Kaken’s STAT6 program, including lead candidate KP-723, a preclinical STAT6 inhibitor, for autoimmune and allergic diseases, including atopic dermatitis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $30.0 million

                            December 26, 2024

                            Lead Product(s) : KP-723

                            Therapeutic Area : Dermatology

                            Highest Development Status : Preclinical

                            Sponsor : Johnson & Johnson

                            Deal Size : $1,247.5 million

                            Deal Type : Licensing Agreement

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                            06

                            Kaken Pharmaceuticals

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                            Kaken Pharmaceuticals

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                            Lead Product(s) : ND081

                            Therapeutic Area : Gastroenterology

                            Study Phase : Preclinical

                            Recipient : Numab Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Numab and Kaken Collaborate On ND081 for Inflammatory Bowel Disease

                            Details : The collaboration aims to develop ND081, a potential first-in-class multi-specific antibody for the treatment of inflammatory bowel disease (IBD).

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $14.6 million

                            November 15, 2024

                            Lead Product(s) : ND081

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Preclinical

                            Recipient : Numab Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

                            Kaken Pharmaceuticals

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                            Aus. Peptide Conference
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                            Kaken Pharmaceuticals

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                            Lead Product(s) : Betahistine Dimesilate

                            Therapeutic Area : Otolaryngology (Ear, Nose, Throat)

                            Study Phase : Approved FDF

                            Recipient : Eisai

                            Deal Size : $25.0 million

                            Deal Type : Divestment

                            DEALS_DEV arrow-down

                            Eisai to Divest Rights for Merislon and Myonal in Japan to Kaken Pharmaceutical

                            Details : Eisai divested its rights for Merislon (betahistine mesilate), used to treat Meniere's syndrome, and muscle relaxant Myonal (eperisone hydrochloride) in Japan to Kaken.

                            Product Name : Merislon

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            March 29, 2024

                            Lead Product(s) : Betahistine Dimesilate

                            Therapeutic Area : Otolaryngology (Ear, Nose, Throat)

                            Highest Development Status : Approved FDF

                            Recipient : Eisai

                            Deal Size : $25.0 million

                            Deal Type : Divestment

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                            08

                            Kaken Pharmaceuticals

                            Japan arrow
                            Aus. Peptide Conference
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                            Kaken Pharmaceuticals

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                            Aus. Peptide Conference
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                            Lead Product(s) : NM26-2198

                            Therapeutic Area : Dermatology

                            Study Phase : Phase I

                            Recipient : Numab Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Numab Therapeutics Announces First Subject Dosed in Phase 1 Clinical Study of NM26 Program

                            Details : NM26-2198 is a bi-specific antibody which targets IL-4Rα (type I and type II receptors) and IL-31 for the treatment of moderate-to-severe atopic dermatitis (AD).

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            May 15, 2023

                            Lead Product(s) : NM26-2198

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase I

                            Recipient : Numab Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Kaken Pharmaceuticals

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                            Kaken Pharmaceuticals

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Discovery

                            Recipient : bitBiome

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            bitBiome and Kaken Pharmaceuticals Sign Joint Research Agreement on The Discovery of Drugs for Infectious Dise...

                            Details : Under the agreement, the companies will utilize the microbial platform technology developed by bitBiome to obtain drug candidates for the treatment of infectious diseases with high unmet medical needs.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            March 29, 2023

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Discovery

                            Recipient : bitBiome

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            10

                            Kaken Pharmaceuticals

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                            Kaken Pharmaceuticals

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                            Lead Product(s) : Seladelpar Lysine

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Recipient : CymaBay Therapeutics

                            Deal Size : $162.4 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            CymaBay Therapeutics Announces Collaboration with Kaken Pharmaceutical Co., Ltd. to Develop and Commercialize ...

                            Details : Under the terms of the agreement, Kaken receives an exclusive license to develop, commercialize and market MBX-8025 (seladelpar), a first-in-class treatment for people with primary biliary cholangitis (PBC), in Japan for PBC.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $34.0 million

                            January 08, 2023

                            Lead Product(s) : Seladelpar Lysine

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Recipient : CymaBay Therapeutics

                            Deal Size : $162.4 million

                            Deal Type : Collaboration

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