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    [{"orgOrder":0,"company":"Catherine Anne Chappell","sponsor":"Gilead Sciences","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Sofosbuvir","moa":"Hepatitis C virus NS5B RNA-dependent RNA polymerase","graph1":"Infections and Infectious Diseases","graph2":"Phase IV","graph3":"Catherine Anne Chappell","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Catherine Anne Chappell \/ Gilead Sciences","highestDevelopmentStatusID":"11","companyTruncated":"Catherine Anne Chappell \/ Gilead Sciences"},{"orgOrder":0,"company":"Catherine Anne Chappell","sponsor":"Gilead Sciences | Gansu Provincial Maternal and Child Health Care Hospital","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Sofosbuvir","moa":"Hepatitis C virus NS5B RNA-dependent RNA polymerase","graph1":"Infections and Infectious Diseases","graph2":"Phase IV","graph3":"Catherine Anne Chappell","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Catherine Anne Chappell \/ Gilead Sciences | Gansu Provincial Maternal and Child Health Care Hospital","highestDevelopmentStatusID":"11","companyTruncated":"Catherine Anne Chappell \/ Gilead Sciences | Gansu Provincial Maternal and Child Health Care Hospital"},{"orgOrder":0,"company":"AIDS Clinical Trials Group","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Sofosbuvir","moa":"||Hepatitis C virus NS5B RNA-dependent RNA polymerase","graph1":"Infections and Infectious Diseases","graph2":"Phase IV","graph3":"AIDS Clinical Trials Group","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"AIDS Clinical Trials Group \/ Inapplicable","highestDevelopmentStatusID":"11","companyTruncated":"AIDS Clinical Trials Group \/ Inapplicable"},{"orgOrder":0,"company":"Columbia University","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Sofosbuvir","moa":"Hepatitis C virus NS5B RNA-dependent RNA polymerase","graph1":"Infections and Infectious Diseases","graph2":"Undisclosed","graph3":"Columbia University","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Columbia University \/ Inapplicable","highestDevelopmentStatusID":"1","companyTruncated":"Columbia University \/ Inapplicable"},{"orgOrder":0,"company":"ANRS, Emerging Infectious Diseases","sponsor":"IRD, Epidemiology and Prevention, Montpellier, France | SESSTIM (IRD, Inserm, Universit\u00e9 Aix-Marseille) | Center for Research on Emerging and Re-Emerging Diseases | Facult\u00e9 de M\u00e9decine et des Sciences Biom\u00e9dicales, Universit\u00e9 de Yaound\u00e9 I, Yaound\u00e9, Camero","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Sofosbuvir","moa":"Hepatitis C virus NS5B RNA-dependent RNA polymerase","graph1":"Infections and Infectious Diseases","graph2":"Phase IV","graph3":"ANRS, Emerging Infectious Diseases","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ANRS, Emerging Infectious Diseases \/ IRD, Epidemiology and Prevention, Montpellier, France | SESSTIM (IRD, Inserm, Universit\u00e9 Aix-Marseille) | Center for Research on Emerging and Re-Emerging Diseases | Facult\u00e9 de M\u00e9decine et des Sciences Biom\u00e9dicales, Universit\u00e9 de Yaound\u00e9 I, Yaound\u00e9, Camero","highestDevelopmentStatusID":"11","companyTruncated":"ANRS, Emerging Infectious Diseases \/ IRD, Epidemiology and Prevention, Montpellier, France | SESSTIM (IRD, Inserm, Universit\u00e9 Aix-Marseille) | Center for Research on Emerging and Re-Emerging Diseases | Facult\u00e9 de M\u00e9decine et des Sciences Biom\u00e9dicales, Universit\u00e9 de Yaound\u00e9 I, Yaound\u00e9, Camero"}]

    Find Clinical Drug Pipeline Developments & Deals for isopropyl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate

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    isopropyl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl]amino]propanoate

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                            01

                            AbbVie Inc

                            U.S.A
                            ESCRS
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy and Safety of Glecaprevir (ABT-493)/Pibrentasvir (ABT 530) (GLE/PIB) in Combination With Sofosbuvir a...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 20, 2016

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            ANRS, Emerging Infectious Diseases

                            Country arrow
                            ESCRS
                            Not Confirmed

                            ANRS, Emerging Infectious Diseases

                            Country arrow
                            ESCRS
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase IV

                            Sponsor : IRD, Epidemiology and Prevention, Montpellier, France | SESSTIM (IRD, Inserm, Université Aix-Marseille) | Center for Research on Emerging and Re-Emerging Diseases | Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé I, Yaoundé, Camero

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of Simplified vs Standard Test & Treat Strategy for Hepatitis C in Cameroon

                            Details : Sofosbuvir is a Other Small Molecule drug candidate, which is currently being evaluated in Phase IV clinical studies for the treatment of Hepatitis C.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 01, 2025

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase IV

                            Sponsor : IRD, Epidemiology and Prevention, Montpellier, France | SESSTIM (IRD, Inserm, Université Aix-Marseille) | Center for Research on Emerging and Re-Emerging Diseases | Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé I, Yaoundé, Camero

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            AIDS Clinical Trials Group

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                            ESCRS
                            Not Confirmed

                            AIDS Clinical Trials Group

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                            ESCRS
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                            Lead Product(s) : Sofosbuvir,Velpatasvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ACTG Announces Publication of Pivotal Hepatitis C Study in Clinical Infectious Diseases

                            Details : ACTG 5360 is a combination of sofosbuvir which is an inhibitor of the HCV NS5B RNA-dependent RNA polymerase, whereas velpatasvir is an inhibitor of the HCV NS5A protein, both required for viral replication. Currently being studied for chronic hepatitis C...

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 23, 2023

                            Lead Product(s) : Sofosbuvir,Velpatasvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase IV

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Catherine Anne Chappell

                            Country arrow
                            ESCRS
                            Not Confirmed

                            Catherine Anne Chappell

                            Country arrow
                            ESCRS
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase IV

                            Sponsor : Gilead Sciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sofosbuvir/Velpatasvir Treatment of Chronic Hepatitis C During Pregnancy

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 02, 2021

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase IV

                            Sponsor : Gilead Sciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Columbia University

                            U.S.A arrow
                            ESCRS
                            Not Confirmed

                            Columbia University

                            U.S.A arrow
                            ESCRS
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Undisclosed

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Researchers Identify Multiple Molecules tat Shut Down SARS-Cov-2 Polymerase Reaction

                            Details : Researchers at Columbia Engineering and the University of Wisconsin-Madison have identified a library of molecules that shut down the SARS-CoV-2 polymerase reaction. Five of these molecules are already FDA-approved for use in the treatment of other viral...

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 30, 2020

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Undisclosed

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Catherine Anne Chappell

                            Country arrow
                            ESCRS
                            Not Confirmed

                            Catherine Anne Chappell

                            Country arrow
                            ESCRS
                            Not Confirmed
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : Gilead Sciences | Gansu Provincial Maternal and Child Health Care Hospital

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Treatment of Chronic Hepatitis C During Pregnancy With Sofosbuvir/Velpatasvir

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 11, 2020

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : Gilead Sciences | Gansu Provincial Maternal and Child Health Care Hospital

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Gilead Sciences

                            U.S.A arrow
                            ESCRS
                            Not Confirmed

                            Gilead Sciences

                            U.S.A arrow
                            ESCRS
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Investigate the Efficacy and Safety of Sofosbuvir/Velpatasvir (SOF/VEL) Fixed-Dose Combination (FDC) ...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 26, 2019

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Gilead Sciences

                            U.S.A arrow
                            ESCRS
                            Not Confirmed

                            Gilead Sciences

                            U.S.A arrow
                            ESCRS
                            Not Confirmed
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Investigate the Efficacy and Safety of Sofosbuvir/Velpatasvir Fixed-Dose Combination for 12 Weeks in ...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 02, 2019

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            University of Pennsylvania

                            Country arrow
                            ESCRS
                            Not Confirmed

                            University of Pennsylvania

                            Country arrow
                            ESCRS
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Gilead Sciences | National Institute of Diabetes and Digestive and Kidney Diseases

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Trial of Transplanting Hepatitis C Kidneys Into Hepatitis C-Negative Kidney Recipients

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 03, 2019

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Gilead Sciences | National Institute of Diabetes and Digestive and Kidney Diseases

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            University of California, San Francisco

                            Country arrow
                            ESCRS
                            Not Confirmed

                            University of California, San Francisco

                            Country arrow
                            ESCRS
                            Not Confirmed
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                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase IV

                            Sponsor : Gilead Sciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            The No One Waits Study: Acceptability and Feasibility of Community-based Point-of-diagnosis HCV Treatment Stud...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 17, 2019

                            Lead Product(s) : Sofosbuvir

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase IV

                            Sponsor : Gilead Sciences

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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