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                            Lead Product(s) : Olezarsen Sodium

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Ionis Announces Positive Essence Study Results of Olezarsen for Triglycerides

                            Details : Tryngolza (olezarsen) is a RNA-targeted medicine being evaluated for sHTG. It is designed to lower apoC-III production, a liver produced protein that regulates triglyceride metabolism in blood.

                            Product Name : Tryngolza

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            May 19, 2025

                            Lead Product(s) : Olezarsen Sodium

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : ION582

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            April 06, 2025

                            Lead Product(s) : ION582

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

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                            iPHEX India
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : BIIB080

                            Therapeutic Area : Neurology

                            Study Phase : Phase II

                            Recipient : Biogen

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Biogen’s BIIB080 Gets FDA Fast Track for Tau-Targeting Alzheimer’s Therapy

                            Details : BIIB080 is an investigational antisense oligonucleotide (ASO) therapy designed to target microtubule-associated protein tau (MAPT) mRNA to reduce the production of tau protein.

                            Product Name : IONIS-MAPTRx

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            April 02, 2025

                            Lead Product(s) : BIIB080

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase II

                            Recipient : Biogen

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

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                            iPHEX India
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : Olezarsen Sodium

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Swedish Orphan Biovitrum AB

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Ionis, Sobi Expand Partnership for Olezarsen Commercialization Outside U.S.

                            Details : Under the licensing agreement, Sobi will hold the exclusive rights in countries outside the U.S., Canada to commercialize Tryngolza (olezarsen sodium) as a potential treatment for FCS.

                            Product Name : Tryngolza

                            Product Type : Oligonucleotide

                            Upfront Cash : Undisclosed

                            March 26, 2025

                            Lead Product(s) : Olezarsen Sodium

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Swedish Orphan Biovitrum AB

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            05

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

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                            iPHEX India
                            Not Confirmed
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                            Lead Product(s) : Sapablursen

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Ono Pharmaceutical

                            Deal Size : $940.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Ionis and Ono Announce Global License Agreement for Sapablursen in Polycythemia Vera

                            Details : Under the licensing agreement, Ono obtains exclusive rights for the development and commercialization of ISIS 702843 (sapablursen), an investigational RNA-targeted medicine for polycythemia vera.

                            Product Name : Undisclosed

                            Product Type : Oligonucleotide

                            Upfront Cash : $280.0 million

                            March 11, 2025

                            Lead Product(s) : Sapablursen

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Ono Pharmaceutical

                            Deal Size : $940.0 million

                            Deal Type : Licensing Agreement

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                            06

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

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                            iPHEX India
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : Eplontersen Sodium

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            WAINZUA Approved in EU for Hereditary Transthyretin Amyloidosis

                            Details : Waiznua (eplontersen) is a transthyretin-directed antisense oligonucleotide. It is indicated for adults with polyneuropathy associated with hereditary transthyretin-mediated amyloidosis.

                            Product Name : Wainzua

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 10, 2025

                            Lead Product(s) : Eplontersen Sodium

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

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                            iPHEX India
                            Not Confirmed
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                            Lead Product(s) : Olezarsen Sodium

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            US FDA Approves Ionis Pharma's Genetic Disorder Drug

                            Details : Tryngolza (olezarsen) is a APOC3 inhibitor, antisense oligonucleotide, which is indicated for the treatment of familial chylomicronemia syndrome.

                            Product Name : Tryngolza

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            December 19, 2024

                            Lead Product(s) : Olezarsen Sodium

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

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                            iPHEX India
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : ION269

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            November 04, 2024

                            Lead Product(s) : ION269

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Eplontersen Sodium

                            Therapeutic Area : Neurology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            WAINZUA (eplontersen) Gets CHMP Nod for Hereditary Amyloidosis Polyneuropathy

                            Details : Waiznua (eplontersen) is a transthyretin-directed antisense oligonucleotide. It is indicated for adults with polyneuropathy associated with hereditary transthyretin-mediated amyloidosis.

                            Product Name : Wainzua

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            October 21, 2024

                            Lead Product(s) : Eplontersen Sodium

                            Therapeutic Area : Neurology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed

                            Ionis Pharmaceuticals

                            U.S.A arrow
                            iPHEX India
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Eplontersen Sodium

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Recipient : AstraZeneca

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            WAINZUA EU Approval Recommended for Transthyretin Amyloidosis Polyneuropathy

                            Details : Wainua (eplontersen sodium) is a transthyretin-directed antisense oligonucleotide. It is approved for the treatment of adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis.

                            Product Name : Wainua

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            October 21, 2024

                            Lead Product(s) : Eplontersen Sodium

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Recipient : AstraZeneca

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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