Drugs in Dev.
Infections and Infectious Diseases
Preclinical
Switzerland 
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Lead Product(s) : Fosmanogepix
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : BARDA
Deal Size : $25.0 million
Deal Type : Funding
Basilea Receives USD 25 Million Funding Under BARDA Agreement
Details : The financing will be used to Basilea to continue to advance the development of Basilea’s novel antifungals APX001 (fosmanogepix), a broad-spectrum antifungal and BAL2062, a first-in-class antifungal.
Product Name : APX001
Product Type : Miscellaneous
Upfront Cash : Undisclosed
September 16, 2025
Lead Product(s) : Fosmanogepix
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : BARDA
Deal Size : $25.0 million
Deal Type : Funding

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Lead Product(s) : BV-500
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Shionogi
Deal Size : $610.3 million
Deal Type : Collaboration
Shionogi offers $600M for Swiss biotech's antibiotic program
Details : The collaboration aims to jointly develop novel ansamycin leads from BioVersys’ BV500 program into clinical candidates for non-tuberculous mycobacteria infections.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $6.3 million
July 02, 2025
Lead Product(s) : BV-500
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Shionogi
Deal Size : $610.3 million
Deal Type : Collaboration

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Lead Product(s) : Debio-1453
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : CARB-X
Deal Size : $20.2 million
Deal Type : Funding
CARB-X Grants Debiopharm $12.3 Million To Advance Novel Antibiotic for Gonorrhea
Details : The grant will support the continued clinical development of Debio 1453, a first-in-class antibiotic with a novel mechanism of action to treat Neisseria gonorrhoeae infections.
Product Name : Undisclosed
Product Type : Antibiotic
Upfront Cash : Undisclosed
May 28, 2025
Lead Product(s) : Debio-1453
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : CARB-X
Deal Size : $20.2 million
Deal Type : Funding

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Lead Product(s) : Debio 1453
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Gardp
Deal Size : Undisclosed
Deal Type : Agreement
GARDP Supports Debiopharm’s Gonorrhoea Treatment Development
Details : Under the agreement, Debiopharm will advance the development of Debio 1453, a novel compound representing a new antibiotic class that targets Neisseria gonorrhoeae.
Product Name : Undisclosed
Product Type : Antibiotic
Upfront Cash : Undisclosed
January 14, 2025
Lead Product(s) : Debio 1453
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Gardp
Deal Size : Undisclosed
Deal Type : Agreement

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Lead Product(s) : BAL2420
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : CARB-X
Deal Size : $7.3 million
Deal Type : Funding
Basilea Receives CARB-X Funding to Develop Novel Antibiotics Candidate
Details : The funding will support the progression of Basilea’s novel antibiotic candidate BAL2420 LptA inhibitor for the treating Infectious Diseases.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
December 23, 2024
Lead Product(s) : BAL2420
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : CARB-X
Deal Size : $7.3 million
Deal Type : Funding

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Lead Product(s) : LBT-SA7
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
LimmaTech Awarded FDA Fast Track Designation for Staphylococcus aureus Vaccine
Details : LBT-SA7 is a multivalent toxoid vaccine candidate, which is designed to prevent skin and soft tissue infections caused by the bacterial pathogen, Staphylococcus aureus.
Product Name : Undisclosed
Product Type : Vaccine
Upfront Cash : Inapplicable
December 19, 2024
Lead Product(s) : LBT-SA7
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Debio 1453
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : CARB-X
Deal Size : $5.7 million
Deal Type : Funding
CARB-X Funds Debiopharm for Antibiotics Against Drug-Resistant Gonorrhoeae
Details : The funding will support the preclinical development of Debio 1453, a novel antibiotic specifically designed to combat Neisseria gonorrhoeae infections.
Product Name : Undisclosed
Product Type : Antibiotic
Upfront Cash : Undisclosed
November 21, 2024
Lead Product(s) : Debio 1453
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : CARB-X
Deal Size : $5.7 million
Deal Type : Funding

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Lead Product(s) : RVX-sCPD9
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : National Institutes of Health
Deal Size : Undisclosed
Deal Type : Collaboration
Rocketvax Collaborates with NIH for Clinical Trial of RVX-sCPD9 Candidate
Details : Through the collaboration, Rocketvax aims to focus on developing the next-generation live-attenuated viral vaccine RVX-sCPD9, which is being evaluated for the treatment of COVID-19.
Product Name : Undisclosed
Product Type : Vaccine
Upfront Cash : Undisclosed
June 13, 2024
Lead Product(s) : RVX-sCPD9
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : National Institutes of Health
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : CARB-X
Deal Size : $0.9 million
Deal Type : Funding
Basilea Awarded CARB-X Grant to Develop Recently Acquired Novel Class of Antibiotics
Details : Funding will support clinical development of first-in-class antibiotics targeting severe infections, particularly those caused by E. coli and K. pneumoniae.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
April 09, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : CARB-X
Deal Size : $0.9 million
Deal Type : Funding

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Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Basilea Pharmaceutica
Deal Size : $2.3 million
Deal Type : Acquisition
Basilea Announces Acquisition of Preclinical Antibiotics Program from Spexis
Details : Through the acquisition, Basilea gains a preclinical program of antibiotics from a novel class, targeting Gram-negative bacteria, including multidrug-resistant strains.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
January 15, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Basilea Pharmaceutica
Deal Size : $2.3 million
Deal Type : Acquisition
