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[{"orgOrder":0,"company":"eTheRNA immunotherapies","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"eTheRNA Launches an International Consortium and Starts Development of Cross-strain Protective CoV-2 mRNA Vaccine","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Preclinical","country":"BELGIUM","productType":"Vaccine","productStatus":"Undisclosed","date":"March 2020","url1":"","url2":"","graph1":"Vaccine","graph2":"eTheRNA immunotherapies"},{"orgOrder":0,"company":"Ziphius Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Ziphius Therapeutics Announces Acceleration of mRNA Based Vaccine Development for COVID-19","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Preclinical","country":"BELGIUM","productType":"Vaccine","productStatus":"New Molecular 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Applicable","newsHeadline":"Anima Research Center Participating In A Trial For An Investigational RSV Vaccine","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Preclinical","country":"BELGIUM","productType":"Vaccine","productStatus":"New Molecular Entity","date":"September 2022","url1":"","url2":"","graph1":"Vaccine","graph2":"Anima Medical Centre"},{"orgOrder":0,"company":"Exothera","sponsor":"CyanVac","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"CyanVac Selects Exothera for the Development and GMP Manufacturing of Its Covid-19 Intranasal Vaccine Candidate for Phase III Clinical Trial","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Preclinical","country":"BELGIUM","productType":"Vaccine","productStatus":"New Molecular Entity","date":"March 2021","url1":"","url2":"","graph1":"Vaccine","graph2":"Exothera"},{"orgOrder":0,"company":"Exothera","sponsor":"Rokote 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Vaccines"},{"orgOrder":0,"company":"AstriVax","sponsor":"Flanders Innovation & Entrepreneurship","pharmaFlowCategory":"D","amount":"$3.2 million","upfrontCash":"Undisclosed","newsHeadline":"AstriVax Awarded \u20ac3 Million Grant to Advance therapeutic Hepatitis B Vaccine","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Preclinical","country":"BELGIUM","productType":"Vaccine","productStatus":"New Molecular Entity","date":"December 2023","url1":"","url2":"","graph1":"Vaccine","graph2":"AstriVax"}]

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            XVR012 is a cocktail of XVR013m and XVR014, targets three distinct epitopes. It is currently being evaluated in preclinical studies for the treatment of Covid-19 infection.

            Lead Product(s): XVR013m,XVR014

            Therapeutic Area: Infections and Infectious Diseases Product Name: XVR012

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 15, 2024

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            The grant will be used to advance AstriVax’ candidate CHB therapeutic vaccine in clinical development for the treatment of chronic Hepatitis B. It efficiently induces specific CD8+ T-cells.

            Lead Product(s): Undisclosed

            Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Vaccine

            Partner/Sponsor/Collaborator: Flanders Innovation & Entrepreneurship

            Deal Size: $3.2 million Upfront Cash: Undisclosed

            Deal Type: Funding December 12, 2023

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            The funding will be used by ExeVir for pre-clinical research towards prophylactic and therapeutic solutions including, XVR021 for dengue by leveraging its unique, modular llama-derived antibody (VHH) technology platform to generate multi-specific antibodies.

            Lead Product(s): XVR021

            Therapeutic Area: Infections and Infectious Diseases Product Name: XVR021

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Flanders Innovation & Entrepreneurship

            Deal Size: $1.7 million Upfront Cash: Undisclosed

            Deal Type: Funding June 28, 2023

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            XVR013 targets a conserved region in the spike S2 subunit that is essential for viral entry. It neutralizes all previous and current variants of concern and the currently most frequently circulating variants, including XBB, XBB.1.5, BQ.1.1 and BF.7.

            Lead Product(s): XVR013

            Therapeutic Area: Infections and Infectious Diseases Product Name: XVR013

            Highest Development Status: Preclinical Product Type: Vaccine

            Partner/Sponsor/Collaborator: VIB

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 13, 2023

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            The EIB financing will help to advance ExeVir’s lead asset, XVR012, into clinical trials for COVID-19. XVR012, is a potent COVID-19 neutralizing antibody that targets the S1 and S2 region of the coronavirus.

            Lead Product(s): XVR012

            Therapeutic Area: Infections and Infectious Diseases Product Name: XVR012

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: European Investment Bank

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Financing January 09, 2023

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            Anima is collaborating with the U.S. pharmaceutical company Moderna, among others, to evaluate an RSV vaccine under development, aimed at persons over 60 years of age.

            Lead Product(s): RSV Vaccine

            Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Vaccine

            Partner/Sponsor/Collaborator: Moderna Therapeutics

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 15, 2022

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            Ziphius Vaccines is developing a proprietary self-amplifying mRNA technology platform combined with innovative lipid formulations for delivery. saRNA or replicon RNA has the advantage of having self-replicating features.

            Lead Product(s): ZIP-1642

            Therapeutic Area: Infections and Infectious Diseases Product Name: ZIP-1642

            Highest Development Status: Preclinical Product Type: Vaccine

            Partner/Sponsor/Collaborator: Charles River Laboratories, Inc

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration June 23, 2022

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            The FINCoVac vaccine is designed to program the nasopharyngeal cells to produce immune response-inducing modified SARS-CoV-2-viral spike protein. FINCoVac 2.0 represents an easy-to-administer booster for those who are already fully vaccinated with other coronavirus vaccines.

            Lead Product(s): FINCoVac 2.0

            Therapeutic Area: Infections and Infectious Diseases Product Name: FINCoVac 2.0

            Highest Development Status: Preclinical Product Type: Vaccine

            Partner/Sponsor/Collaborator: Rokote Laboratories

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership April 01, 2022

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            Details:

            Exothera will be responsible for the fast-track development of a manufacturing process for CyanVac’s COVID-19 vaccine candidate, CVXGA1, using the unique scale-X™ platform.

            Lead Product(s): CVXGA1

            Therapeutic Area: Infections and Infectious Diseases Product Name: CVXGA1

            Highest Development Status: Preclinical Product Type: Vaccine

            Partner/Sponsor/Collaborator: CyanVac

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration March 24, 2021

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            Lead asset VHH72-Fc binds to a unique epitope that is conserved in SARS-CoV-1 and SARS-CoV-2 viruses and this binding prevents these viruses from entering the cell.

            Lead Product(s): VHH72-FC,Ad26.COV2-S

            Therapeutic Area: Infections and Infectious Diseases Product Name: VHH72-FC

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Undisclosed

            Deal Size: $27.1 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing May 28, 2020

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