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[{"orgOrder":0,"company":"Seqirus","sponsor":"BARDA","pharmaFlowCategory":"D","amount":"$30.1 million","upfrontCash":"Undisclosed","newsHeadline":"CSL Seqirus Announces U.S. Government Award to Manufacture and Clinically Assess Influenza A(H5N8) Pre-Pandemic Vaccine","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Preclinical","country":"AUSTRALIA","productType":"Vaccine","productStatus":"New Molecular Entity","date":"October 2022","url1":"","url2":"","graph1":"Vaccine","graph2":"Seqirus"},{"orgOrder":0,"company":"Seqirus","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"CSL Announces Positive Preclinical Data for Self-Amplifying Messenger RNA (sa-mRNA) Influenza Vaccine Candidates","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Preclinical","country":"AUSTRALIA","productType":"Vaccine","productStatus":"New Molecular Entity","date":"October 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Find Clinical Drug Development Pipelines & Deals | PipelineProspector
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Treatment with R327 (RECCE® 327) has shown to significantly reduce SARS-CoV-2 levels in a dose-dependent manner in throat swab samples collected from animals. This study provides proof-of-concept that IN treatment with R327 has the potential to reduce SARS-CoV-2 levels.
Lead Product(s):
R327
Therapeutic Area: Infections and Infectious Diseases Product Name: RECCE 327
Highest Development Status: Preclinical Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableOctober 18, 2022
Details:
Under the terms of the agreement, CSL Seqirus will deliver an H5N8 A/Astrakhan virus vaccine candidate and will then sponsor a subsequent Phase 2 clinical trial to evaluate the candidate along with CSL Seqirus' proprietary adjuvant MF59®.
Lead Product(s):
H5N8 A/Astrakhan Virus Vaccine,Squalene
Therapeutic Area: Infections and Infectious Diseases Product Name: H5N8 A/Astrakhan
Highest Development Status: Preclinical Product Type: Vaccine
Partner/Sponsor/Collaborator:
BARDA
Deal Size: $30.1 millionUpfront Cash: Undisclosed
Deal Type: AgreementOctober 06, 2022
Details:
The results demonstrate that the A(H5N1) sa-mRNA influenza vaccine candidate induced an anti-HA and anti-NA neutralizing response raised by sa-mRNA influenza vaccines at a dose as low as 0.01 µg in mice and also induced HA-specific CD4+ T cells.
Lead Product(s):
sa-mRNA Influenza Vaccine
Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed
Highest Development Status: Preclinical Product Type: Vaccine
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableOctober 05, 2022
Details:
In consideration of research findings, the rapid evolution of the virus and changing treatment landscape presents significant challenges to conduct a clinical trial for SARS-CoV-2 with IMM-124E (travelan).
Lead Product(s):
Bovine Colostrum
Therapeutic Area: Infections and Infectious Diseases Product Name: Travelan
Highest Development Status: Preclinical Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableAugust 19, 2022
Details:
This Government Grant & Academic collaboration solidify Medlab’s transition to a true Biotech company. The NanoCelle® non-invasive nasal delivered vaccine is considered a “first in class” medicine delivery system.
Lead Product(s):
mRNA Vaccine
Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed
Highest Development Status: Preclinical Product Type: Vaccine
Partner/Sponsor/Collaborator:
Macquarie University
Deal Size: UndisclosedUpfront Cash: Undisclosed
Deal Type: CollaborationJanuary 14, 2022
Details:
Of the 36 candidates in clinical development, R327 is the only synthetic polymer drug candidate and the only clinical stage antibiotic for the indication of sepsis – globally.
Lead Product(s):
R327
Therapeutic Area: Infections and Infectious Diseases Product Name: RECCE 327
Highest Development Status: Preclinical Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableOctober 26, 2021
Details:
Patented lead candidate RECCE® 327 as an intravenous therapy, is being developed for treatment of serious and potentially life-threatening infections including sepsis due to Gram-positive and Gramnegative bacteria including their superbug forms.
Lead Product(s):
R327
Therapeutic Area: Infections and Infectious Diseases Product Name: R327
Highest Development Status: Preclinical Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableJuly 22, 2021
Details:
RECCE® 111 is a non-descript title for an experimental compound, developed in-house, building upon the unique mechanisms of action of RECCE® 327. Positive sinusitis infection data indicated in animal study.
Lead Product(s):
R327
Therapeutic Area: Infections and Infectious Diseases Product Name: R327
Highest Development Status: Preclinical Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableApril 01, 2021
Details:
The licensed technology combines Alterity’s PBT2 and other zinc ionophores with commonly used antibiotics to treat infections caused by multidrug resistant bacteria. This is an opportunity for Alterity to further leverage its investment in PBT2.
Lead Product(s):
PBT2
Therapeutic Area: Infections and Infectious Diseases Product Name: PBT2
Highest Development Status: Preclinical Product Type: Small molecule
Partner/Sponsor/Collaborator:
Alterity Therapeutics
Deal Size: UndisclosedUpfront Cash: Undisclosed
Deal Type: PartnershipDecember 21, 2020
Details:
A New Research Services Agreement has been executed with Monash University to advance the SARS-CoV-2 findings and to further research and identify the inhibitory substance/s in Immuron’s marketed products (IMM-124E).
Lead Product(s):
IMM-124E
Therapeutic Area: Infections and Infectious Diseases Product Name: Travelan
Highest Development Status: Preclinical Product Type: Large molecule
Partner/Sponsor/Collaborator:
Monash University
Deal Size: UndisclosedUpfront Cash: Undisclosed
Deal Type: AgreementDecember 15, 2020
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