Athena Athena

X
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Enabling","country":"AUSTRALIA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"May 2023","url1":"","url2":"","graph1":"Oncology","graph2":"IND Enabling"},{"orgOrder":0,"company":"Immutep","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Immutep Receives Positive Feedback from FDA on Late-Stage Clinical Development of Eftilagimod Alpha in Non-Small Cell Lung Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"AUSTRALIA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"May 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"},{"orgOrder":0,"company":"Immutep","sponsor":"Merck & Co","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Immutep Efti in Combination with Pembrolizumab Achieves Excellent Initial Overall Survival Benefit in 1st Line Non-Small Cell Lung Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"AUSTRALIA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"May 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"},{"orgOrder":0,"company":"Immutep","sponsor":"GSK","pharmaFlowCategory":"D","amount":"$100.0 million","upfrontCash":"Undisclosed","newsHeadline":"Ulcerative Colitis Phase II Study of GSK2831781 Discontinued","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase II","country":"AUSTRALIA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"January 2021","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Phase II"},{"orgOrder":0,"company":"Immutep","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Immutep Announces Promising New Clinical Data from Triple Combination Therapy in INSIGHT-003 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Agency","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II\/ Phase III","country":"AUSTRALIA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"August 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II\/ Phase III"},{"orgOrder":0,"company":"Immutep","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Immutep Completes Enrollment in TACTI-003 Phase IIb Trial of Efti and KEYTRUDA\u00ae in First Line Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"AUSTRALIA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"November 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"},{"orgOrder":0,"company":"Immutep","sponsor":"Merck & Co","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not 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Applicable","upfrontCash":"Not Applicable","newsHeadline":"Immutep Receives Constructive Regulatory Feedback on TACTI-004 Registrational Trial in Metastatic Non-Small Cell Lung Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"AUSTRALIA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"December 2023","url1":"","url2":"","graph1":"Oncology","graph2":"Phase II"}]

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            Efti (eftilagimod alpha) a soluble LAG-3 protein and MHC Class II agonist is being evaluated in combination with Bavencio (avelumab) under phase 1 clinical trials forthe treatment of patients with metastatic urothelial carcinoma.

            Lead Product(s): Eftilagimod Alpha,Avelumab

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Merck Group

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 04, 2024

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            IMP321 (eftilagimod alpha), a soluble LAG-3 protein and MHC Class II agonist that stimulates both innate and adaptive immunity. It is being evaluated in phase 2 clinial trials for first line treatment of metastatic non-small cell lung cancer & head & neck squamous cell cancer.

            Lead Product(s): Eftilagimod Alpha,Pembrolizumab

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 21, 2023

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            IMP321 (Eftilagimod Alpha) is an antigen presenting cell activator for the treatment of cancer. It is being investigated in combination with MSD’s anti-PD-1 therapy pembrolizumab as first-line treatment of recurrent or metastatic head and neck squamous cell carcinoma.

            Lead Product(s): Eftilagimod Alpha,Pembrolizumab

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 09, 2023

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            IMP321 (eftilagimod alpha) is an antigen presenting cell activator for the treatment of cancer, capitalising on LAG-3’s to stimulate both innate and adaptive immunity. It is being investigated in phase II trial in combination with KEYTRUDA for NSCLC.

            Lead Product(s): Eftilagimod Alpha,Pembrolizumab

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Merck & Co

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 03, 2023

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            IMP321 (Eftilagimod Alpha) is an antigen presenting cell activator for the treatment of cancer, capitalising on LAG-3’s to stimulate both innate and adaptive immunity. It is being investigated in phase III trial in non-small cell lung cancer.

            Lead Product(s): Eftilagimod Alpha,Paclitaxel

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase II/ Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 01, 2023

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            IMP321 (Eftilagimod Alpha) is an antigen presenting cell activator for the treatment of cancer, capitalising on LAG-3’s to stimulate both innate and adaptive immunity. It is being investigated in phase II trial in combination with KEYTRUDA for soft tissue sarcoma.

            Lead Product(s): Eftilagimod Alpha,Pembrolizumab

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable July 28, 2023

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            Under the agreement, Charles River will conduct a GLP toxicology study for IMP761, a first-in-class LAG-3 agonist antibody and Immutep's proprietary preclinical candidate for autoimmune diseases.

            Lead Product(s): IMP761

            Therapeutic Area: Immunology Product Name: IMP761

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Charles River Laboratories

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement May 29, 2023

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            IMP321 (Eftilagimod Alpha) is an antigen presenting cell activator for the treatment of cancer, capitalising on LAG-3’s to stimulate both innate and adaptive immunity. It is being investigated in phase II trial in soft tissue sarcoma in neoadjuvant setting.

            Lead Product(s): Eftilagimod Alpha,Paclitaxel

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase II/ Phase III Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 25, 2023

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            IMP321 (Eftilagimod Alpha) is an antigen presenting cell activator for the treatment of cancer, capitalising on LAG-3’s to stimulate both innate and adaptive immunity. It is being investigated in phase II trial in soft tissue sarcoma in neoadjuvant setting.

            Lead Product(s): Eftilagimod Alpha,Pembrolizumab,Carboplatin

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 24, 2023

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            IMP321 (eftilagimod alpha) binds and activates LAG-3 leading in expansion and proliferation of CD8+ (cytotoxic) T cells, CD4+ (helper) T cells, dendritic cells, NK cells, and monocytes. It is being investigated for NSCLC in combination with pembrolizumab.

            Lead Product(s): Eftilagimod Alpha,Pembrolizumab,Carboplatin

            Therapeutic Area: Oncology Product Name: IMP321

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Merck & Co

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 17, 2023

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