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    [{"orgOrder":0,"company":"Zura Bio","sponsor":"Deep Track Capital","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2023","type":"Private Placement","leadProduct":"Tibulizumab","moa":"IL-17 receptor\/BAFF receptor","graph1":"Immunology","graph2":"Phase I","graph3":"Zura Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Zura Bio \/ Deep Track Capital","highestDevelopmentStatusID":"6","companyTruncated":"Zura Bio \/ Deep Track Capital"},{"orgOrder":0,"company":"Agility Life Sciences","sponsor":"Conduit Pharma","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2025","type":"Partnership","leadProduct":"CDT1656","moa":"Glucokinase","graph1":"Immunology","graph2":"Phase I","graph3":"Agility Life Sciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Agility Life Sciences \/ Conduit Pharma","highestDevelopmentStatusID":"6","companyTruncated":"Agility Life Sciences \/ Conduit Pharma"},{"orgOrder":0,"company":"MiroBio","sponsor":"Medicxi","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2022","type":"Series B Financing","leadProduct":"MB272","moa":"BTLA","graph1":"Immunology","graph2":"Phase I","graph3":"MiroBio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MiroBio \/ Medicxi","highestDevelopmentStatusID":"6","companyTruncated":"MiroBio \/ Medicxi"},{"orgOrder":0,"company":"MiroBio","sponsor":"Gilead Sciences","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2022","type":"Acquisition","leadProduct":"MB272","moa":"BTLA","graph1":"Immunology","graph2":"Phase I","graph3":"MiroBio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MiroBio \/ Gilead Sciences","highestDevelopmentStatusID":"6","companyTruncated":"MiroBio \/ Gilead Sciences"},{"orgOrder":0,"company":"MiroBio","sponsor":"Gilead Sciences","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2022","type":"Acquisition","leadProduct":"MB272","moa":"BTLA","graph1":"Immunology","graph2":"Phase I","graph3":"MiroBio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MiroBio \/ Gilead Sciences","highestDevelopmentStatusID":"6","companyTruncated":"MiroBio \/ Gilead Sciences"},{"orgOrder":0,"company":"MiroBio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"MB272","moa":"BTLA","graph1":"Immunology","graph2":"Phase I","graph3":"MiroBio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"MiroBio \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"MiroBio \/ Inapplicable"},{"orgOrder":0,"company":"BenevolentAI","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"BEN-8744","moa":"PDE10","graph1":"Immunology","graph2":"Phase I","graph3":"BenevolentAI","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"BenevolentAI \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"BenevolentAI \/ Inapplicable"},{"orgOrder":0,"company":"BenevolentAI","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"BEN-8744","moa":"PDE10","graph1":"Immunology","graph2":"Phase I","graph3":"BenevolentAI","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"BenevolentAI \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"BenevolentAI \/ Inapplicable"},{"orgOrder":0,"company":"BenevolentAI","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"BEN-8744","moa":"PDE10","graph1":"Immunology","graph2":"Phase I","graph3":"BenevolentAI","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"BenevolentAI \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"BenevolentAI \/ Inapplicable"},{"orgOrder":0,"company":"Microbiotica","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Probiotic","year":"2025","type":"Inapplicable","leadProduct":"MB310","moa":"Gut microbiome","graph1":"Immunology","graph2":"Phase I","graph3":"Microbiotica","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Microbiotica \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Microbiotica \/ Inapplicable"},{"orgOrder":0,"company":"Tiziana Life Sciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Foralumab","moa":"CD3","graph1":"Immunology","graph2":"Phase I","graph3":"Tiziana Life Sciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Tiziana Life Sciences \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Tiziana Life Sciences \/ Inapplicable"},{"orgOrder":0,"company":"Tiziana Life Sciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2022","type":"Inapplicable","leadProduct":"Foralumab","moa":"CD3","graph1":"Immunology","graph2":"Phase I","graph3":"Tiziana Life Sciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Tiziana Life Sciences \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Tiziana Life Sciences \/ Inapplicable"},{"orgOrder":0,"company":"Tiziana Life Sciences","sponsor":"Thinkequity","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2020","type":"Public Offering","leadProduct":"Foralumab","moa":"CD3","graph1":"Immunology","graph2":"Phase I","graph3":"Tiziana Life Sciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Tiziana Life Sciences \/ Thinkequity","highestDevelopmentStatusID":"6","companyTruncated":"Tiziana Life Sciences \/ Thinkequity"},{"orgOrder":0,"company":"Kynos Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"KNS366","moa":"KMO","graph1":"Immunology","graph2":"Phase I","graph3":"Kynos Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Kynos Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Kynos Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"NodThera","sponsor":"Organovo Holdings","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2020","type":"Series B Financing","leadProduct":"NT-0167","moa":"NLRP3","graph1":"Immunology","graph2":"Phase I","graph3":"NodThera","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"NodThera \/ Organovo Holdings","highestDevelopmentStatusID":"6","companyTruncated":"NodThera \/ Organovo Holdings"},{"orgOrder":0,"company":"Oxford Biomedica","sponsor":"Kyverna Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Cell and Gene therapy","year":"2023","type":"Licensing Agreement","leadProduct":"KYV-101","moa":"CD19","graph1":"Immunology","graph2":"Phase I","graph3":"Oxford Biomedica","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Oxford Biomedica \/ Kyverna Therapeutics","highestDevelopmentStatusID":"6","companyTruncated":"Oxford Biomedica \/ Kyverna Therapeutics"},{"orgOrder":0,"company":"Zura Bio","sponsor":"Access Biotechnology","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2024","type":"Private Placement","leadProduct":"Tibulizumab","moa":"IL-17 receptor\/BAFF receptor","graph1":"Immunology","graph2":"Phase I","graph3":"Zura Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Zura Bio \/ Access Biotechnology","highestDevelopmentStatusID":"6","companyTruncated":"Zura Bio \/ Access Biotechnology"},{"orgOrder":0,"company":"Zura Bio","sponsor":"Deep Track Capital","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"UNITED KINGDOM","productType":"Antibody","year":"2023","type":"Private Placement","leadProduct":"Tibulizumab","moa":"IL-17 receptor\/BAFF receptor","graph1":"Immunology","graph2":"Phase I","graph3":"Zura Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Zura Bio \/ Deep Track Capital","highestDevelopmentStatusID":"6","companyTruncated":"Zura Bio \/ Deep Track Capital"}]

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                            01

                            Microbiotica

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                            Microbiotica

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                            Lead Product(s) : MB310

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Microbiotica Reveals MOA Data for MB310 in Ulcerative Colitis Treatment

                            Details : MB310 is an oral live biotherapeutic product which is currently being evaluated for the treatment of patients with active, mild-to-moderate ulcerative colitis.

                            Product Name : MB310

                            Product Type : Probiotic

                            Upfront Cash : Inapplicable

                            February 21, 2025

                            Lead Product(s) : MB310

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Agility Life Sciences

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                            Agility Life Sciences

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                            Lead Product(s) : CDT1656

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Conduit Pharma

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Conduit, Agility Life Sciences Collaborate on Autoimmune Pipeline Formulations

                            Details : The partnership aims to develop new solid oral-dosage form products of its autoimmune pipeline for use in future clinical trials, which includes CDT1656 for treating autoimmune diseases.

                            Product Name : CDT1656

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            January 22, 2025

                            Lead Product(s) : CDT1656

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Conduit Pharma

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            03

                            Kynos Therapeutics

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                            Kynos Therapeutics

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                            Lead Product(s) : KNS366

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Kynos Announces Positive Results from First-in-Human Phase I Study of KMO Inhibitor KNS366

                            Details : KNS366 is a first-in-class small molecule kynurenine 3-monooxygenase (KMO) inhibitor, which is being evaluated for the treatment of acute and chronic inflammation.

                            Product Name : KNS366

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 22, 2024

                            Lead Product(s) : KNS366

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Zura Bio

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                            Zura Bio

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                            Lead Product(s) : Tibulizumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Access Biotechnology

                            Deal Size : $112.5 million

                            Deal Type : Private Placement

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                            Zura Bio Announces Oversubscribed $112.5 Million Private Placement

                            Details : Net proceeds will accelerate development of ZB-106 (tibulizumab), including a planned Phase 2 trial in systemic sclerosis and another evaluating its use for hidradenitis suppurativa.

                            Product Name : ZB-106

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            April 18, 2024

                            Lead Product(s) : Tibulizumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Access Biotechnology

                            Deal Size : $112.5 million

                            Deal Type : Private Placement

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                            05

                            BenevolentAI

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                            BenevolentAI

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                            Lead Product(s) : BEN-8744

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BenevolentAI Announces Positive Topline Data From Phase Ia Study Of BEN-8744

                            Details : BEN-8744 is an orally administered, peripherally-restricted PDE10 inhibitor, which is being developed as a potential first-in-class treatment for patients with moderate to severe ulcerative colitis.

                            Product Name : BEN-8744

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 25, 2024

                            Lead Product(s) : BEN-8744

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Oxford Biomedica

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                            Oxford Biomedica

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                            Lead Product(s) : KYV-101

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Kyverna Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            Kyverna Therapeutics and Oxford Biomedica Sign License and Supply Agreement for LentiVector® Platform

                            Details : Under the agreement, Kyverna gains access to LentiVector® platform, the first commercially approved lentiviral-based gene delivery system, to use with any Kyverna product, including its anti-CD19 CAR T-cell therapies, KYV-101 and KYV-201 which specifica...

                            Product Name : KYV-101

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            September 20, 2023

                            Lead Product(s) : KYV-101

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Kyverna Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            07

                            BenevolentAI

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                            BenevolentAI

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                            Lead Product(s) : BEN-8744

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            BenevolentAI Doses First Participants in Clinical Trial of BEN-8744; Targets PDE10, an AI-derived Novel Target...

                            Details : BEN-8744 is a peripherally restricted small molecule and derived from the Benevolent PlatformTM and is a potential first-in-class PDE10 inhibitor for the treatment of Ulcerative Colitis.

                            Product Name : BEN-8744

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 31, 2023

                            Lead Product(s) : BEN-8744

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Zura Bio

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                            Zura Bio

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                            Lead Product(s) : Tibulizumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Deep Track Capital

                            Deal Size : $80.0 million

                            Deal Type : Private Placement

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                            Zura Bio Completes Approximately $80 Million Financing with the Focus on Advancing ZB-106, a Potential First-i...

                            Details : The funding will allow Zura Bio to initiate a Phase 2 clinical trial for ZB-106 (tibulizumab), a potential first-in-class anti-IL-17 and anti-BAFF dual antagonist, in systemic sclerosis (SSc), followed by a Phase 2 clinical trial in hidradenitis suppurat...

                            Product Name : ZB-106

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            June 06, 2023

                            Lead Product(s) : Tibulizumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Deep Track Capital

                            Deal Size : $80.0 million

                            Deal Type : Private Placement

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                            09

                            Zura Bio

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                            Zura Bio

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                            Lead Product(s) : Tibulizumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Deep Track Capital

                            Deal Size : $80.0 million

                            Deal Type : Private Placement

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                            Zura Bio Announces $80 Million Financing and the Licensing of Tibulizumab (ZB-106), a Potential First-in-Class...

                            Details : The net proceedings will be used to to initiate a Phase 2 study for ZB-106 (tibulizumab), a potential first-in-class, anti-IL-17 and anti-BAFF dual antagonist, in Systemic Sclerosis.

                            Product Name : ZB-106

                            Product Type : Antibody

                            Upfront Cash : $80.0 million

                            April 27, 2023

                            Lead Product(s) : Tibulizumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Deep Track Capital

                            Deal Size : $80.0 million

                            Deal Type : Private Placement

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                            10

                            MiroBio

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                            MiroBio

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                            Lead Product(s) : MB272

                            Therapeutic Area : Immunology

                            Study Phase : Phase I

                            Sponsor : Gilead Sciences

                            Deal Size : $405.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Gilead Sciences Completes Acquisition of MiroBio

                            Details : The acquisition provides Gilead with MiroBio’s proprietary discovery platform and entire portfolio of immune inhibitory receptor agonists. MiroBio’s lead MB272, is a selective agonist of immune inhibitory receptor B and T-Lymphocyte Attenuator.

                            Product Name : MB272

                            Product Type : Antibody

                            Upfront Cash : $405.0 million

                            September 20, 2022

                            Lead Product(s) : MB272

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase I

                            Sponsor : Gilead Sciences

                            Deal Size : $405.0 million

                            Deal Type : Acquisition

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