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    [{"orgOrder":0,"company":"Idera Pharmaceuticals","sponsor":"Not Applicable ","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Idera Pharmaceuticals completes enrollment in registrational trial","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"March 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"Idera Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"D","amount":"$20.7 million","upfrontCash":"Undisclosed","newsHeadline":"Idera Pharmaceuticals Announces Private Placement of up to $20.7 Million","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"April 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase III"},{"orgOrder":0,"company":"Idera 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              Idera Pharmaceuticals

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              Idera Pharmaceuticals Acquires Aceragen

              Details:

              The combined cash of the two companies is expected to provide runway into Q3 2023, funding the advancement of Aceragen’s pipeline, including ACG-701 (sodium fusidate) and ACG-801, through important 2023 clinical milestones.

              Lead Product(s): Sodium Fusidate,Ceftazidime,Meropenem

              Therapeutic Area: Infections and Infectious Diseases Product Name: ACG-701

              Highest Development Status: Phase II Product Type: Small molecule

              Recipient: Aceragen

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Acquisition September 28, 2022

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              Idera Pharmaceuticals

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              Idera Pharmaceuticals Shares Positive Results from Investigator-Sponsored Trial in Melanoma Patients at Amsterdam UMC

              Details:

              Tilsotolimod is an investigational, synthetic Toll-like receptor 9 agonist. Tilsotolimod (IMO-2125) has been shown to promote both innate (Type-I IFN, antigen presentation) and adaptive immune activation and may, in turn, contribute to tumor suppression and regression.

              Lead Product(s): Tilsotolimod,Ipilimumab

              Therapeutic Area: Oncology Product Name: IMO-2125

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 17, 2022

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              Idera Pharmaceuticals

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              Idera Pharmaceuticals Announces Tilsotolimod Updates

              Details:

              Company announced clinical updates regarding IMO-2125 (tilsotolimod), its synthetic Toll-like receptor 9 agonist has been shown to promote both innate (Type-I IFN, antigen presentation) and adaptive (T cells) immune activation.

              Lead Product(s): Tilsotolimod,Nivolumab,Ipilimumab

              Therapeutic Area: Oncology Product Name: IMO-2125

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: AbbVie Inc

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable December 14, 2021

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              Idera Pharmaceuticals

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              Idera Pharmaceuticals Announces Results from Illuminate-301 Trial of Tilsotolimod + Ipilimumab in Anti-PD-1 Refractory Advanced Melanoma

              Details:

              ILLUMINATE-301 is a randomized, global, multi-center, open label Phase 3 trial comparing the efficacy of 8 mg intratumoral tilsotolimod in combination with 3 mg/kg ipilimumab versus 3 mg/kg ipilimumab alone in 481 patients with anti-PD-1 refractory advanced melanoma.

              Lead Product(s): Tilsotolimod,Ipilimumab

              Therapeutic Area: Oncology Product Name: IMO-2125

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Bristol Myers Squibb

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 18, 2021

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              Idera Pharmaceuticals Announces $5.0 Million in Further Proceeds from Private Placement of up to $20.7 Million

              Details:

              The Company plans to use the $10.0 million in cash proceeds to fund the completion of the ongoing ILLUMINATE-301 clinical trial and potential NDA filing of its lead product, tilsotolimod, for the treatment of anti-PD-1 refractory metastatic melanoma.

              Lead Product(s): Tilsotolimod,Ipilimumab

              Therapeutic Area: Oncology Product Name: IMO-2125

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Undisclosed

              Deal Size: $20.7 million Upfront Cash: Undisclosed

              Deal Type: Private Placement December 15, 2020

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              Idera Pharmaceuticals Announces New U.S. Patent Coverage for Tilsotolimod Through September 2037

              Details:

              This new coverage expands protection of the first tilsotolimod method-of-use patent, which was directed to methods of treating metastatic melanoma and was issued in November 2019.

              Lead Product(s): Tilsotolimod,Ipilimumab

              Therapeutic Area: Oncology Product Name: IMO-2125

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable September 28, 2020

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              Idera Pharmaceuticals to Present Tilsotolimod Data at ESMO Virtual Congress 2020

              Details:

              ILLUMINATE-204 is a multi-center, two-arm phase 1/2 trial in patients with anti-PD-1 refractory advanced melanoma. The phase 1 portion of the trial tested the safety and efficacy of increasing doses of tilsotolimod in combination with either Yervoy®* or Keytruda®.

              Lead Product(s): Tilsotolimod,Ipilimumab

              Therapeutic Area: Oncology Product Name: IMO-2125

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable September 15, 2020

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              Idera Pharmaceuticals Announces Private Placement of up to $20.0 Million

              Details:

              The Company plans to use the initial proceeds and, if exercised, subsequent proceeds from the financing for the ongoing clinical development of tilsotolimod, its potential NDA filing and commercial launch, and for general corporate purposes.

              Lead Product(s): Tilsotolimod,Ipilimumab

              Therapeutic Area: Oncology Product Name: IMO-2125

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Undisclosed

              Deal Size: $20.0 million Upfront Cash: Undisclosed

              Deal Type: Private Placement July 15, 2020

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              Idera Pharmaceuticals Reports Data From and Planned Continuation of the ILLUMINATE-206 Trial for Micro-Satellite Stable Colorectal Cancer

              Details:

              Tilsotolimod in combination with Opdivo® (nivolumab) and Yervoy®* (ipilimumab) was generally well tolerated; no patients discontinued treatment due to adverse events (AEs) and none experienced Grade 4 or 5 AEs.

              Lead Product(s): Tilsotolimod,Ipilimumab,Nivolumab

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable June 02, 2020

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              Idera Pharmaceuticals Announces Final Clinical Safety And Efficacy Data From Illuminate-204 Trial In Advanced Melanoma

              Details:

              The combination regimen was generally well tolerated among the 62 patients receiving tilsotolimod at any dose in combination with Yervoy® in the ILLUMINATE-204 clinical trial.

              Lead Product(s): Tilsotolimod,Ipilimumab,Pembrolizumab

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable April 21, 2020

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