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Find Clinical Drug Development Pipelines & Deals | PipelineProspector
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BJT-188 is a liver-targeted fatty acid synthase (FASN) inhibitor, which is being investigated for the treatment of metabolic dysfunction-associated steatohepatitis.
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The proceeds will be used to push a liver-rejuvenating mRNA medicine into clinic. The preclinical asset uses lipid nanoparticles to deliver mRNA to liver cells that codes for transcription factors.
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insitro has an option to in-license GalNAc delivery technology from Lilly that it will combine with two different siRNA, each specifically directed toward a different target in the liver.
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PRO-140 (leronlimab) a monocloncal antibody works by blocking the activity of CCR5 receptor. It is currently in preclinical in combination with Resmetirom for the treatment of liver fibrosis.
Details :
The collaboration focuses on developing Oxy210 (oxysterol), a small-molecule antifibrotic, evaluated in preclinical studies for non-alcoholic steatohepatitis and pulmonary fibrosis.
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OCE-205 is a therapeutic peptide with a differentiated mechanism of action. It is being evaluated in preclinical studies for the treatment of Ascites due to all etiologies except cancer.
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Under the agreement, GENFIT will advance Celloram’s first-in-class inflammasome inhibitor, CLM-022, a triterpenoid derivative that targets the inflammasome machinery, in liver disease indications.
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CM5480 is a selective oral CRAC channel inhibitor and restored the expression of SOCE-associated regulatory factor in acinar cells, which being developed for Chronic Pancreatitis (CP).
Details :
INI-822 a small molecule inhibitor of HSD17B13, data showed favorable drug properties and in vivo changes in lipid metabolism consistent with those observed with protective forms of HSD17B13.
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