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Gall Bladder)","country":"U.S.A","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"Seladelpar Lysine","moa":"PPA-delta receptor","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Pinnacle Clinical Research","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pinnacle Clinical Research \/ CymaBay Therapeutics","highestDevelopmentStatusID":"10","companyTruncated":"Pinnacle Clinical Research \/ CymaBay Therapeutics"},{"orgOrder":0,"company":"CymaBay Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Inapplicable","leadProduct":"Seladelpar Lysine","moa":"PPA-delta receptor","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"CymaBay Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"CymaBay Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"CymaBay Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"CHIRHOCLIN","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Protein","year":"2010","type":"Inapplicable","leadProduct":"Chirhostim","moa":"Secretin receptor","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"CHIRHOCLIN","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Injection","sponsorNew":"CHIRHOCLIN \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"CHIRHOCLIN \/ Undisclosed"},{"orgOrder":0,"company":"Eisai Inc","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Miscellaneous","year":"2013","type":"Inapplicable","leadProduct":"Avatrombopag Maleate","moa":"Thrombopoietin receptor","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Eisai Inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Eisai Inc \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Eisai Inc \/ Undisclosed"},{"orgOrder":0,"company":"Eisai Inc","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Miscellaneous","year":"2013","type":"Inapplicable","leadProduct":"Avatrombopag Maleate","moa":"Thrombopoietin receptor","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Eisai Inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Eisai Inc \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Eisai Inc \/ Undisclosed"},{"orgOrder":0,"company":"PathAI, inc","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"Resmetirom","moa":"Thyroid hormone receptor beta-1","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"PathAI, inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"PathAI, inc \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"PathAI, inc \/ Undisclosed"},{"orgOrder":0,"company":"Madrigal Pharmaceuticals","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Resmetirom","moa":"Thyroid hormone receptor beta-1","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Madrigal Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Madrigal Pharmaceuticals \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Madrigal Pharmaceuticals \/ Undisclosed"},{"orgOrder":0,"company":"Forest Laboratories","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Undisclosed","year":"2012","type":"Inapplicable","leadProduct":"EUR-1008","moa":"Undisclosed","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Forest Laboratories","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Forest Laboratories \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Forest Laboratories \/ Undisclosed"},{"orgOrder":0,"company":"Abbott Laboratories","sponsor":"PPD","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Plant Extract\/Herbal","year":"2012","type":"Inapplicable","leadProduct":"Ademetionine","moa":"Undisclosed","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Abbott Laboratories","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Abbott Laboratories \/ PPD","highestDevelopmentStatusID":"10","companyTruncated":"Abbott Laboratories \/ PPD"},{"orgOrder":0,"company":"89bio","sponsor":"F. Hoffmann-La Roche","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Protein","year":"2025","type":"Acquisition","leadProduct":"Pegozafermin","moa":"FGF21","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"89bio","amount2":3.5,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":3.5,"dosageForm":"Injection","sponsorNew":"89bio \/ F. Hoffmann-La Roche","highestDevelopmentStatusID":"10","companyTruncated":"89bio \/ F. Hoffmann-La Roche"},{"orgOrder":0,"company":"Eli Lilly","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Peptide, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"Tirzepatide","moa":"Glucagon-like peptide 1 receptor | Gastric inhibitory polypeptide receptor","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Eli Lilly","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Eli Lilly \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"Eli Lilly \/ Undisclosed"},{"orgOrder":0,"company":"Akero Therapeutics","sponsor":"Novo Nordisk","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"U.S.A","productType":"Protein","year":"2025","type":"Acquisition","leadProduct":"Efruxifermin","moa":"GPCR","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase III","graph3":"Akero Therapeutics","amount2":5.2000000000000002,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Hepatology","amount2New":5.2000000000000002,"dosageForm":"Injection","sponsorNew":"Akero Therapeutics \/ Novo Nordisk","highestDevelopmentStatusID":"10","companyTruncated":"Akero Therapeutics \/ Novo Nordisk"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            Akero Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
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                            Akero Therapeutics

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                            Lead Product(s) : Efruxifermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : Novo Nordisk

                            Deal Size : $5,200.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Novo Nordisk Acquires Akero Therapeutics for Phase 3 FGF21 Analogue in MASH Portfolio

                            Details : Through the acquisition, Novo will leverage Akero pipeline which includes Efruxifermin, a protein targeting growth factors, for the treatment of MASH.

                            Product Name : EFX

                            Product Type : Protein

                            Upfront Cash : $5,200.0 million

                            October 09, 2025

                            Lead Product(s) : Efruxifermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : Novo Nordisk

                            Deal Size : $5,200.0 million

                            Deal Type : Acquisition

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                            02

                            89bio

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            89bio

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                            AIChE Annual Meeting
                            Not Confirmed
                            • fda
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                            • WHO-GMP
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                            Lead Product(s) : Pegozafermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $3,500.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Roche Enters into a Definitive Merger Agreement to Acquire 89bio

                            Details : Acquisition supports Roche’s strategy as it enhances the company’s portfolio in CVRM, including BIO89-100 (pegozafermin) is a FGF21 analog currently in late-stage development for MASH.

                            Product Name : BIO89-100

                            Product Type : Protein

                            Upfront Cash : $3,500.0 million

                            September 18, 2025

                            Lead Product(s) : Pegozafermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : F. Hoffmann-La Roche

                            Deal Size : $3,500.0 million

                            Deal Type : Acquisition

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                            03

                            Eli Lilly

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            Eli Lilly

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                            Not Confirmed
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                            Lead Product(s) : Tirzepatide

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (...

                            Details : Tirzepatide is a Peptide, Unconjugated drug candidate, which is currently being evaluated in Phase III clinical studies for the treatment of Non-alcoholic Fatty Liver Disease.

                            Product Name : Undisclosed

                            Product Type : Peptide, Unconjugated

                            Upfront Cash : Inapplicable

                            September 10, 2025

                            Lead Product(s) : Tirzepatide

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Madrigal Pharmaceuticals

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            Madrigal Pharmaceuticals

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                            AIChE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Resmetirom

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Madrigal Reports Two-Year Data Showing Rezdiffra Benefit in MASH Cirrhosis

                            Details : Rezdiffra (resmetirom) is a once-daily, oral THR-β agonist designed to target key underlying causes of NASH. It is being studied in compensated patients with NASH cirrhosis.

                            Product Name : Rezdiffra

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 26, 2025

                            Lead Product(s) : Resmetirom

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            89bio

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            89bio

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Pegozafermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $287.5 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            89bio Closes Public Offering, Underwriters’ Option Fully Exercised

                            Details : 89bio intends to use the net proceeds to fund clinical development of BIO89-100 (pegozafermin) for the treatment of metabolic dysfunction-associated steatohepatitis and severe hypertriglyceridemia.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            February 03, 2025

                            Lead Product(s) : Pegozafermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $287.5 million

                            Deal Type : Public Offering

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                            06

                            Akero Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            Akero Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
                            • fda
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                            Lead Product(s) : Efruxifermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $402.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Akero Therapeutics Announces Closing of Upsized Public Offering of Common Stock

                            Details : The net proceeds will be used to advance the clinical development of lead product EFX (efruxifermin). It is being evaluated for the treatment of compensated cirrhosis due to MASH.

                            Product Name : EFX

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 30, 2025

                            Lead Product(s) : Efruxifermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $402.0 million

                            Deal Type : Public Offering

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                            07

                            89bio

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            89bio

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Pegozafermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $250.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            89bio, Inc. Announces Pricing of $250.0 Million Public Offering of Common Stock

                            Details : 89bio intends to use the net proceeds to fund clinical development of BIO89-100 (pegozafermin) for the treatment of metabolic dysfunction-associated steatohepatitis and severe hypertriglyceridemia.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 28, 2025

                            Lead Product(s) : Pegozafermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $250.0 million

                            Deal Type : Public Offering

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                            08

                            Akero Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            Akero Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed
                            • fda
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                            Lead Product(s) : Efruxifermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $350.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Akero Therapeutics Announces Pricing of Upsized Public Offering of Common Stock

                            Details : The net proceeds will be to advance the clinical development of lead product EFX (efruxifermin). It is being evaluated for the treatment of compensated cirrhosis due to MASH.

                            Product Name : EFX

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 28, 2025

                            Lead Product(s) : Efruxifermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $350.0 million

                            Deal Type : Public Offering

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                            09

                            89bio

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            89bio

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Pegozafermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $250.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            89bio Announces Proposed Underwritten Public Offering of Common Stock

                            Details : 89bio intends to use the net proceeds to fund clinical development of BIO89-100 (pegozafermin) for the treatment of metabolic dysfunction-associated steatohepatitis and severe hypertriglyceridemia.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 27, 2025

                            Lead Product(s) : Pegozafermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : Goldman Sachs & Co

                            Deal Size : $250.0 million

                            Deal Type : Public Offering

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                            10

                            Akero Therapeutics

                            U.S.A arrow
                            AIChE Annual Meeting
                            Not Confirmed

                            Akero Therapeutics

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                            AIChE Annual Meeting
                            Not Confirmed
                            • fda
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                            • WHO-GMP
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                            Lead Product(s) : Efruxifermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Akero’s Symmetry Study Shows Reversal of MASH Cirrhosis at Week 96

                            Details : EFX (efruxifermin) is a differentiated Fc-FGF21 fusion protein drug candidate, which is being evaluated for the treatment of patients with compensated cirrhosis (F4) due to MASH.

                            Product Name : EFX

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 27, 2025

                            Lead Product(s) : Efruxifermin

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase III

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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