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Lead Product(s): MET409
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET409
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable October 01, 2020
Details:
The findings showed robust and sustained FXR activation, which Metacrine believes is key to optimizing therapeutic benefits. Combined with a favorable pharmacological and tolerability profile, the results support the therapeutic potential of MET409 for patients with NASH.
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Lead Product(s): EP547
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: EP547
Highest Development Status: Phase I Product Type: Undisclosed
Partner/Sponsor/Collaborator: Sanofi Ventures
Deal Size: $77.5 million Upfront Cash: Undisclosed
Deal Type: Series B Financing September 14, 2020
Details:
Proceeds support clinical development for lead program in cholestatic and uremic pruritus and second program for mast cell-related diseases.
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Lead Product(s): TERN-201
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: TERN-201
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable September 10, 2020
Details:
Terns recently completed a Phase 1 clinical study of TERN-201, which demonstrated that single and multiple oral administrations of TERN-201 were well tolerated with no significant safety findings observed.
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Lead Product(s): MET409
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET409
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 27, 2020
Details:
MET409 demonstrated notable improvements in decreased liver fat content and differentiated impacts on pruritus and LDL cholesterol after 12 weeks of treatment in NASH patients .
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Lead Product(s): AXA1125,AXA1957
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: AXA1125
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 27, 2020
Details:
Poster presentation contains data demonstrating AXA1125’s multifactorial effects on markers of metabolism, inflammation and fibrosis in subjects with NAFLD.
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Lead Product(s): CB4211
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: CB4211
Highest Development Status: Phase I Product Type: Peptide
Partner/Sponsor/Collaborator: Roth Capital Partners
Deal Size: $15.0 million Upfront Cash: Undisclosed
Deal Type: Public Offering August 25, 2020
Details:
CohBar intends to use the net proceeds from the offering, together with its existing cash resources, for general corporate purposes, funding preclinical and clinical development of its peptides, increasing working capital, operating expenses and capital expenditures.
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Lead Product(s): MET409
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET409
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable August 25, 2020
Details:
U.S. Food & Drug Administration (FDA) has granted Fast Track designation to MET409, the company’s lead farnesoid X receptor (FXR) agonist, for the treatment of non-alcoholic steatohepatitis (NASH).
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Lead Product(s): TERN-201
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: TERN-201
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable July 30, 2020
Details:
Results from single and multiple ascending dose cohorts demonstrate TERN-201 is generally safe and well tolerated and results in potent and sustained inhibition of plasma SSAO activity.
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Lead Product(s): CB4211
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: CB4211
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable July 07, 2020
Details:
CohBar has resumed the Phase 1b stage of its Phase 1a/1b clinical trial of CB4211, its lead candidate for the treatment of nonalcoholic steatohepatitis (NASH) and obesity.
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Lead Product(s): CRV431
Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: CRV431
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator: Not Applicable
Deal Size: Not Applicable Upfront Cash: Not Applicable
Deal Type: Not Applicable June 23, 2020
Details:
Mice that underwent left ureter surgical ligation were orally administered either vehicle or CRV431 at a dose of 50 mg/kg/day for two weeks (n=8 mice/group).
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