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                          01

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : The collaboration with Genentech will enable Orionis to leverage its Allo-Glue platform for the discovery of small-molecule monovalent glue targets in major disease areas, including oncology.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $105.0 million

                          May 21, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Recipient : Orionis Biosciences

                          Deal Size : $2,105.0 million

                          Deal Type : Collaboration

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                          02

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          February 28, 2025

                          Lead Product(s) : RO7446603

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : CT-996 is an investigational, once-daily, oral small molecule GLP-1 receptor agonist being developed for the treatment of both type 2 diabetes and obesity.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 09, 2024

                          Lead Product(s) : CT-996

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          November 01, 2024

                          Lead Product(s) : Glofitamab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Recipient : MD Anderson Cancer Center

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : Nykode regains control of VB10.NEO cancer vaccine program, a proprietary individualized neoantigen vaccine in development for the treatment of locally advanced or metastatic solid tumors.

                          Product Name : Undisclosed

                          Product Type : Vaccine

                          Upfront Cash : $200.0 million

                          August 11, 2024

                          Lead Product(s) : VB10.NEO,Bempegaldesleukin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Nykode Therapeutics

                          Deal Size : $715.0 million

                          Deal Type : Termination

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                          06

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : CT-996 is an investigational, once-daily, oral small molecule GLP-1 receptor agonist being developed for the treatment of both type 2 diabetes and obesity.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 17, 2024

                          Lead Product(s) : CT-996

                          Therapeutic Area : Nutrition and Weight Loss

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          April 18, 2024

                          Lead Product(s) : RO7617991

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : MTIG7192A (tiragolumab) is an antibody, whch selectively binds to TIGIT. It is currently being evaluated for the treatment of unresectable or metastatic non-squamous non-small cell lung cancer.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          April 07, 2024

                          Lead Product(s) : Tiragolumab,Atezolizumab,Pemetrexed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : F. Hoffmann-La Roche

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : The collaboration aims for the development and commercialization of COUR’s proprietary tolerogenic nanoparticle treatments for an autoimmune disease.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $40.0 million

                          March 12, 2024

                          Lead Product(s) : Tolerogenic Nanoparticle

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Recipient : Cour Pharmaceuticals

                          Deal Size : $940.0 million

                          Deal Type : Collaboration

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                          10

                          Pharmaconex
                          Not Confirmed
                          Pharmaconex
                          Not Confirmed

                          Details : Inqovi is a combination of decitabine and cedazuridine, evaluated in combination with venetoclax for treating higher-risk myelodysplastic syndromes and chronic myelomonocytic leukemia.

                          Product Name : Undisclosed

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          February 22, 2024

                          Lead Product(s) : Decitabine,Cedazuridine,Venetoclax

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Astex Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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