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    [{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"Aflibercept","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Gemini Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2021","type":"Inapplicable","leadProduct":"Aflibercept","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Gemini Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2021","type":"Inapplicable","leadProduct":"Inapplicable","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Gemini Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2021","type":"Inapplicable","leadProduct":"Inapplicable","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Gemini Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"Inapplicable","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Gemini Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Fs Development Corp","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2020","type":"Merger","leadProduct":"Inapplicable","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Gemini Therapeutics \/ Fs Development Corp","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Fs Development Corp"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"Inapplicable","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Intravitreal Injection","sponsorNew":"Gemini Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Disc medicine","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Merger","leadProduct":"Bitopertin","moa":"||GlyT1","graph1":"Genetic Disease","graph2":"Phase II\/ Phase III","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Gemini Therapeutics \/ Gemini Therapeutics","highestDevelopmentStatusID":"9","companyTruncated":"Gemini Therapeutics \/ Gemini Therapeutics"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"GEM103","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Gemini Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Gemini Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2020","type":"Inapplicable","leadProduct":"GEM103","moa":"||Complement Factor H","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Gemini Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Gemini Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Gemini Therapeutics \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Gemini Therapeutics

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                            01

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

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                            EPSC
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                            Lead Product(s) : Bitopertin,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Recipient : Disc medicine

                            Deal Size : $175.0 million

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Disc Medicine Announces Completion of Merger with Gemini Therapeutics

                            Details : Disc Medicine (bitopertin) is an oral, selective inhibitor of glycine transporter 1. is developing bitopertin as the potentially first disease-modifying therapy to treat erythropoietic porphyrias – a family of rare, genetic disorders caused by dysregul...

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            December 29, 2022

                            Lead Product(s) : Bitopertin,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Recipient : Disc medicine

                            Deal Size : $175.0 million

                            Deal Type : Merger

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                            02

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Gemini Therapeutics Completes Enrollment in Phase 2a Trial of GEM103 in Dry AMD in Patients with High-Risk Gen...

                            Details : ReGAtta is a dose escalation trial of GEM103, a recombinant human complement factor H (CFH), in dry AMD patients with CFH loss-of-function gene variants.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            October 02, 2021

                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

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                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Recombinant Human Complement Factor H,Aflibercept

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Gemini Therapeutics Completes Enrollment in Phase 2a Study of GEM103 as an Add-On to Anti-VEGF Therapy for Wet...

                            Details : The team’s ability to overenroll the study highlights the unmet need and the potential for GEM103 to address these suboptimal outcomes in the setting of regular anti-VEGF therapy and its subsequent depletion in CFH levels causing complement dysfunction...

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            May 13, 2021

                            Lead Product(s) : Recombinant Human Complement Factor H,Aflibercept

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

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                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Gemini Therapeutics Announces Initiation of GEM103 Phase 2a Study as an Add-On to Anti-VEGF Therapy for Wet AM...

                            Details : ReGAtta is a dose escalation trial of GEM103, in dry AMD patients with CFH loss-of-function gene variants. GEM103 targets a genetically-defined subset of age-related macular degeneration (AMD) patients with complement dysregulation.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 02, 2021

                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

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                            EPSC
                            Not Confirmed
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                            Lead Product(s) : GEM103,Aflibercept

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Neovascular Age-related Macular Degenerat...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            December 24, 2020

                            Lead Product(s) : GEM103,Aflibercept

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

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                            EPSC
                            Not Confirmed
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                            Lead Product(s) : GEM103,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Dry Age-related Macular Degeneration

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            November 25, 2020

                            Lead Product(s) : GEM103,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Gemini Therapeutics Announces GEM103 Meets All Endpoints in Phase 1 Clinical Study

                            Details : Results showed that, in the four ascending single IVT doses tested (50, 100, 250 and 500 µg of GEM103 in a 50µL dose volume), there were no inflammation, anti-drug antibody, or treatment-related adverse events. A single intravitreal injection of GEM103...

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            November 13, 2020

                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            • WHO-GMP
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                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Fs Development Corp

                            Deal Size : $216.0 million

                            Deal Type : Merger

                            DEALS_DEV arrow-down

                            Gemini Therapeutics and FS Development Corp. Announce Merger Agreement Creating Publicly Listed Precision Medi...

                            Details : Proceeds from the transaction are expected to provide Gemini with the capital needed to further develop its clinical programs and preclinical portfolio, including GEM103, Further clinical programs in selected wet AMD populations, Future programs to treat...

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            October 15, 2020

                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Fs Development Corp

                            Deal Size : $216.0 million

                            Deal Type : Merger

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                            09

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

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                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Gemini Therapeutics Enrolls First Patient in Phase 1 Study of GEM103 for Dry Age-related Macular Degeneration

                            Details : The company looking forward to topline data from this study and the potential to initiate a Phase 2 study supported by the CLARITY natural history study data.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            September 01, 2020

                            Lead Product(s) : Recombinant Human Complement Factor H,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Gemini Therapeutics

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Gemini Therapeutics

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                            EPSC
                            Not Confirmed
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                            Lead Product(s) : GEM103,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            First in Human Study to Evaluate the Safety and Tolerability of GEM103 in Geographic Atrophy Secondary to Dry ...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            January 29, 2020

                            Lead Product(s) : GEM103,Inapplicable

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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