X
[{"orgOrder":0,"company":"Innovation Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Innovation Pharmaceuticals Announces Dosing of First Cohort in Phase 1 Trial of Oral Brilacidin in Ulcerative Colitis Program; Topline Results Anticipated Early Q1 2020","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2020","url1":"","url2":"","graph1":"Small molecule","graph2":"Innovation Pharmaceuticals"},{"orgOrder":0,"company":"Gossamer Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"gossamer bio announces data presentation at the 2020 crohn\u2019s & colitis congress","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Small 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Platform","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"June 2020","url1":"","url2":"","graph1":"Large molecule","graph2":"Pandion Therapeutics"},{"orgOrder":0,"company":"Assembly Biosciences","sponsor":"AbbVie Inc","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Assembly Biosciences Regains Worldwide Rights to Microbiome Gastrointestinal Development Programs","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Large molecule","productStatus":"New Molecular Entity","date":"June 2020","url1":"","url2":"","graph1":"Large molecule","graph2":"Assembly Biosciences"},{"orgOrder":0,"company":"Oppilan Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Oppilan Pharma Announces Positive Phase 1 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EQ102 is a bi-specific cytokine inhibitor that selectively targets IL-15 and IL-21, has demonstrated the prevention of intestinal tissue damage in a humanized mouse model of gastrointestinal inflammation.
Lead Product(s):
EQ102
Therapeutic Area: Gastroenterology Product Name: EQ102
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableNovember 02, 2022
Details:
Single ascending doses of IMU-856 were found to be safe and well-tolerated and no maximum tolerated dose was reached. No serious adverse events occurred. Moreover, a dose-linear PK profile was observed across the investigated dose range.
Lead Product(s):
IMU-856
Therapeutic Area: Gastroenterology Product Name: IMU-856
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableSeptember 20, 2022
Details:
IMU-856, a novel, is an orally available small molecule modulator that targets a protein which serves as a transcriptional regulator of intestinal barrier function and regeneration of bowel epithelium.
Lead Product(s):
IMU-856
Therapeutic Area: Gastroenterology Product Name: IMU-856
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableAugust 16, 2022
Details:
NX-13 is a novel, gut-restricted, orally active, small molecule therapeutic candidate for the treatment of UC. NX-13 targets NLRX1, a mitochondria-associated receptor with the ability to modulate immune responses.
Lead Product(s):
NX-13
Therapeutic Area: Gastroenterology Product Name: NX-13
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableAugust 03, 2022
Details:
DES-7114, is an orally administered, highly selective small-molecule inhibitor of the ion channel protein Kv1.3. It has recently completed Phase 1 clinical trials in healthy volunteers and has demonstrated efficacy in preclinical models of inflammatory and autoimmune diseases.
Lead Product(s):
DES-7114
Therapeutic Area: Gastroenterology Product Name: DES-7114
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator:
Eli Lilly
Deal Size: $535.0 millionUpfront Cash: $60.0 million
Deal Type: Licensing AgreementJune 13, 2022
Details:
The data demonstrate that in an acute dextran sodium sulfate (DSS) epithelial damage model, SZN-1326 promoted mucosal healing by transiently inducing epithelial progenitor cell expansion and accelerating epithelial repair.
Lead Product(s):
SZN-1326
Therapeutic Area: Gastroenterology Product Name: SZN-1326
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableMay 24, 2022
Details:
SZN-1326 is the first development candidate designed using Surrozen’s SWAP™ technology and targets the Wnt-signaling pathway in the intestinal epithelium. In preclinical animal models of acute and chronic colitis.
Lead Product(s):
SZN-1326
Therapeutic Area: Gastroenterology Product Name: SZN-1326
Highest Development Status: Phase I Product Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableMay 18, 2022
Details:
Preclinical studies suggest that IMU-856 can restore barrier function in the gastrointestinal tract and also regenerate intestinal architecture while maintaining immunocompetency. Based on preclinical and early clinical data available to date.
Lead Product(s):
IMU-856
Therapeutic Area: Gastroenterology Product Name: IMU-856
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableMay 05, 2022
Details:
The data presented α4β7 expression of immune cells at single-cell resolution in blood and assessed the dose-dependent effect of MORF-057, small-molecule inhibitor of the α4β7 integrin for patients with inflammatory bowel disease administration in nonhuman primates.
Lead Product(s):
MORF-057
Therapeutic Area: Gastroenterology Product Name: MORF-057
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableFebruary 22, 2022
Details:
LB1148, serine protease inhibitor designed to neutralize activity of potent digestive proteases released from the gut during surgery, also prevent damage to GI tissues, accelerate time to return normal GI function, and shorten duration of costly post-surgery hospital stays.
Lead Product(s):
Tranexamic Acid
Therapeutic Area: Gastroenterology Product Name: LB1148
Highest Development Status: Phase I Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Deal Type: Not ApplicableFebruary 08, 2022
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