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            Proceeds will support Phase 2 candidate AGMB-129/ORG-129 for Fibrostenosing Crohn’s Disease and development of a highly innovative pipeline of anti-fibrotic and regenerative therapies, including AGMB-447 for idiopathic pulmonary fibrosis.

            Lead Product(s): ORG-129

            Therapeutic Area: Gastroenterology Product Name: AGMB-129

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: EQT Life Sciences

            Deal Size: $100.0 million Upfront Cash: Undisclosed

            Deal Type: Series C Financing October 11, 2023

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            Details:

            AGMB-129 (ORG-129) is an oral, small molecule GI-restricted inhibitor of ALK-5 (or TGFbR1) for the treatment of Fibrostenosing Crohn’s Disease. TGFb is a known master regulator of fibrosis and preliminary clinical data supports targeting the pathway in fibrotic indications.

            Lead Product(s): ORG-129

            Therapeutic Area: Gastroenterology Product Name: AGMB-129

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 02, 2023

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            Agomab’s pipeline consists of its lead candidate AGMB-129, a gastrointestinal tract restricted ALK-5 inhibitor for the treatment of fibrostenotic Crohn’s disease that is currently being investigated in a Phase 1 clinical trial in healthy volunteers.

            Lead Product(s): ORG-129

            Therapeutic Area: Gastroenterology Product Name: AGMB-129

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Pfizer Inc

            Deal Size: $114.0 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing July 13, 2022

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            Filgotinib, an orally administered, preferential JAK1 inhibitor, used in the induction and maintenance of remission in patients with Crohn’s disease (CD).

            Lead Product(s): Filgotinib

            Therapeutic Area: Gastroenterology Product Name: Jyseleca

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 04, 2021

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