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    [{"orgOrder":0,"company":"Fusion Pharma","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Fusion Pharmaceuticals Update Regarding FPI-1434 Clinical Trial","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I","country":"CANADA","productType":"Large molecule","productStatus":"New Molecular Entity","date":"August 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I"},{"orgOrder":0,"company":"Fusion Pharma","sponsor":"AstraZeneca","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Fusion Pharmaceuticals Collaborates with AstraZeneca to Develop and Commercialize Next-Gen Radiopharmaceuticals and Gene Therapy","therapeuticArea":"Oncology","highestDevelopmentStatus":"Discovery","country":"CANADA","productType":"Large molecule","productStatus":"Undisclosed","date":"November 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              Fusion Pharma

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              AstraZeneca to Acquire Fusion to Accelerate the Development of Next-generation Radioconjugates to Treat Cancer

              Details:

              The acquisition complements AstraZeneca's leading oncology portfolio with the addition of the Fusion pipeline of RCs, including their most advanced programme, FPI-2265, a potential new treatment for patients with metastatic castration-resistant prostate cancer (mCRPC).

              Lead Product(s): Ac225-PSMA

              Therapeutic Area: Oncology Product Name: FPI-2265

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: AstraZeneca

              Deal Size: $2,400.0 million Upfront Cash: $2,000.0 million

              Deal Type: Acquisition March 19, 2024

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              Fusion Pharmaceuticals Enters into Exclusive Worldwide License Agreement with Heidelberg University and Euratom for Actinium-Based PSMA Targeted Radiotherapy

              Details:

              The license agreement grants Fusion exclusive worldwide rights to develop and commercialize compounds covered by the patent, which includes FPI-2265 for the treatment of prostate-specific membrane antigen-expressing cancers.

              Lead Product(s): Ac225-PSMA

              Therapeutic Area: Oncology Product Name: FPI-2265

              Highest Development Status: Phase II Product Type: Small molecule

              Recipient: Heidelberg University

              Deal Size: $1.0 million Upfront Cash: Undisclosed

              Deal Type: Licensing Agreement February 16, 2024

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              Fusion Pharma Marks In-House Radiopharma Manufacturing Success, Details PhII/III Trial Study

              Details:

              FPI-2265 (Ac225-PSMA) is a targeted alpha therapy (TAT) targeting prostate specific membrane antigen (PSMA). It is under phase 2/3 clinical development for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) with progressive disease.

              Lead Product(s): Ac225-PSMA

              Therapeutic Area: Oncology Product Name: FPI-2265

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 05, 2024

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              Fusion Pharma

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              BWXT Medical Expands Collaboration with Fusion Pharmaceuticals through Strengthened Actinium Supply and Access to Generator Technology

              Details:

              Under the agreement, BWXT Medical, will provide Fusion with a preferential supply of radium-225 and access to high-specific activity generator technology, enabling Fusion for advancing its pipeline of targeted alpha therapies.

              Lead Product(s): Actinium-225

              Therapeutic Area: Oncology Product Name: Undisclosed

              Highest Development Status: Undisclosed Product Type: Small molecule

              Recipient: BWX Technologies

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Expanded Collaboration November 16, 2023

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              Fusion Pharmaceuticals Announces IND Clearance for FPI-2068, a Jointly Developed Novel Targeted Alpha Therapy

              Details:

              [225Ac]-FPI-2068 (FPI-2068) is a targeted alpha therapy (TAT) designed to deliver actinium-225 to various solid tumors that express EGFR and cMET. EGFR and cMET are validated cancer targets that are co-expressed in multiple tumor types.

              Lead Product(s): [225-Actinium]-FPI-2068

              Therapeutic Area: Oncology Product Name: FPI-2068

              Highest Development Status: IND Enabling Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable April 12, 2023

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              Fusion Pharma

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              Fusion Pharmaceuticals Announces First Patient Dosed in Phase 1 Study of FPI-2059, a Targeted Alpha Therapy (TAT) for the Treatment of Solid Tumors Expressing NTSR1

              Details:

              FPI-2059 is a small molecule targeted alpha therapy designed to deliver actinium-225 to tumor sites expressing neurotensin receptor 1 (NTSR1), a protein that is overexpressed in gastrointestinal, prostate, pancreatic ductal adenocarcinoma and multiple other cancers.

              Lead Product(s): FPI-2059,FPI-2058

              Therapeutic Area: Oncology Product Name: FPI-2059

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 20, 2023

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              RadioMedix Inc. Announces the Acquisition of its 225Ac-PSMA I&T program, a Targeted Alpha Therapy (TAT) for Metastatic Castration Resistant Prostate Cancer, by Fusion Pharm...

              Details:

              Through the acquisition of Phase 2 program evaluating 225Ac-PSMA I&T, a small molecule targeting prostate specific membrane antigen ("PSMA") expressed on prostate cancers, strengthens the pipeline of innovative targeted alpha therapies.

              Lead Product(s): Ac225-PSMA

              Therapeutic Area: Oncology Product Name: Ac225-PSMA

              Highest Development Status: Phase II Product Type: Small molecule

              Recipient: RadioMedix

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Acquisition February 15, 2023

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              Fusion Pharmaceuticals and BWXT Medical Announce Actinium-225 Partnership to Scale Supply for Developing Targeted Alpha Therapies

              Details:

              [111In]-FPI-1547 is a targeted radioimmuno-imaging agent that consists of FPI-1175, an insulin-like growth factor-1 receptor (IGF-1R)-targeting humanized monoclonal antibody, a bifunctional chelate, and Indium-111, a radionuclide.

              Lead Product(s): [225Ac]-FPI-1434

              Therapeutic Area: Oncology Product Name: [225Ac]-FPI-1434

              Highest Development Status: Phase I/ Phase II Product Type: Large molecule

              Partner/Sponsor/Collaborator: BWX Technologies

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Agreement January 05, 2023

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              Fusion Pharmaceuticals Announces First Patient Dosed in Phase 1/2 Study of FPI-1966 In Patients with Advanced Solid Tumors Expressing FGFR3

              Details:

              FPI-1966 is a targeted alpha therapy designed to target and deliver an alpha emitting medical isotope, actinium-225, to cancer cells expressing FGFR3; a receptor that is overexpressed on several tumor types, including bladder, ovarian and head and neck cancers.

              Lead Product(s): Actinium-225-Vofatamab

              Therapeutic Area: Oncology Product Name: [225Ac]-FPI-1966

              Highest Development Status: IND Enabling Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 29, 2022

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              Fusion Pharmaceuticals Announces FDA Clearance of IND for FPI-2059, an Investigational Small Molecule-Based Radiopharmaceutical Targeting Solid Tumors Expressing NTSR1

              Details:

              [225Ac]-FPI-2059 (FPI-2059) is a targeted alpha therapy combining actinium-225 with a small molecule designed to target neurotensin receptor 1 (NTSR1), in development as a potential treatment for various solid tumors.

              Lead Product(s): 225Ac-IPN-1087

              Therapeutic Area: Oncology Product Name: FPI-2059

              Highest Development Status: IND Enabling Product Type: Small molecule

              Partner/Sponsor/Collaborator: Ipsen

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable June 23, 2022

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