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    [{"orgOrder":0,"company":"Actinium pharmaceuticals","sponsor":"AbbVie Inc","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2020","type":"Inapplicable","leadProduct":"Ac-225 Lintuzumab","moa":"||CD33","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Actinium pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Actinium pharmaceuticals \/ AbbVie Inc","highestDevelopmentStatusID":"7","companyTruncated":"Actinium pharmaceuticals \/ AbbVie Inc"},{"orgOrder":0,"company":"Actinium pharmaceuticals","sponsor":"The Division of Cancer Treatment and Diagnosis","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2023","type":"Agreement","leadProduct":"Ac-225 Lintuzumab","moa":"||CD33","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Actinium pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Actinium pharmaceuticals \/ The Division of Cancer Treatment and Diagnosis","highestDevelopmentStatusID":"7","companyTruncated":"Actinium pharmaceuticals \/ The Division of Cancer Treatment and Diagnosis"},{"orgOrder":0,"company":"Actinium pharmaceuticals","sponsor":"Eckert & Ziegler Strahlen","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Agreement","leadProduct":"Ac-225 Lintuzumab","moa":"||CD33","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Actinium pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Actinium pharmaceuticals \/ Eckert & Ziegler Strahlen","highestDevelopmentStatusID":"7","companyTruncated":"Actinium pharmaceuticals \/ Eckert & Ziegler Strahlen"},{"orgOrder":0,"company":"Actinium pharmaceuticals","sponsor":"AbbVie Inc","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2020","type":"Inapplicable","leadProduct":"Ac-225 Lintuzumab","moa":"||CD33","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Actinium pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Actinium pharmaceuticals \/ AbbVie Inc","highestDevelopmentStatusID":"7","companyTruncated":"Actinium pharmaceuticals \/ AbbVie Inc"},{"orgOrder":0,"company":"SPH Sine Pharmaceutical Laboratories Co., Ltd.","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"CHINA","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Undisclosed","graph2":"Phase I","graph3":"SPH Sine Pharmaceutical Laboratories Co., Ltd.","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Tablet","sponsorNew":"SPH Sine Pharmaceutical Laboratories Co., Ltd. \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"SPH Sine Pharmaceutical Laboratories Co., Ltd. \/ Undisclosed"},{"orgOrder":0,"company":"Svendborg Hospital","sponsor":"Region of Southern Denmark | Takeda Pharmaceutical","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"DENMARK","productType":"Miscellaneous","year":"2016","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase III","graph3":"Svendborg Hospital","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Svendborg Hospital \/ Region of Southern Denmark | Takeda Pharmaceutical","highestDevelopmentStatusID":"10","companyTruncated":"Svendborg Hospital \/ Region of Southern Denmark | Takeda Pharmaceutical"},{"orgOrder":0,"company":"Orion Corporation","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"FINLAND","productType":"Miscellaneous","year":"2010","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Undisclosed","graph2":"Phase I","graph3":"Orion Corporation","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Orion Corporation \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Orion Corporation \/ Undisclosed"},{"orgOrder":0,"company":"Piedmont Healthcare","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Miscellaneous","year":"2019","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Piedmont Healthcare","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Piedmont Healthcare \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Piedmont Healthcare \/ Undisclosed"},{"orgOrder":0,"company":"University Hospitals Cleveland Medical Center","sponsor":"Relypsa","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Miscellaneous","year":"2018","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Endocrinology","graph2":"Phase IV","graph3":"University Hospitals Cleveland Medical Center","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"University Hospitals Cleveland Medical Center \/ Relypsa","highestDevelopmentStatusID":"11","companyTruncated":"University Hospitals Cleveland Medical Center \/ Relypsa"},{"orgOrder":0,"company":"ResMed","sponsor":"ResMed Foundation","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Miscellaneous","year":"2013","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Undisclosed","graph3":"ResMed","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ResMed \/ ResMed Foundation","highestDevelopmentStatusID":"1","companyTruncated":"ResMed \/ ResMed Foundation"},{"orgOrder":0,"company":"Pfizer Inc","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Undisclosed","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Undisclosed","graph2":"Phase I","graph3":"Pfizer Inc","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pfizer Inc \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Pfizer Inc \/ Undisclosed"},{"orgOrder":0,"company":"CMP Development","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase IV","graph3":"CMP Development","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Suspension","sponsorNew":"CMP Development \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"CMP Development \/ Undisclosed"},{"orgOrder":0,"company":"Dialysis Outcomes Heart Failure Aldactone Study Group","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"","productType":"Miscellaneous","year":"2012","type":"Inapplicable","leadProduct":"Spironolactone","moa":"Mineralocorticoid receptor","graph1":"Nephrology","graph2":"Phase IV","graph3":"Dialysis Outcomes Heart Failure Aldactone Study Group","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Dialysis Outcomes Heart Failure Aldactone Study Group \/ Undisclosed","highestDevelopmentStatusID":"11","companyTruncated":"Dialysis Outcomes Heart Failure Aldactone Study Group \/ Undisclosed"}]

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    Espironolactona

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                            01

                            Orion Corporation

                            Finland
                            Florida Innovation
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                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Pharmacokinetic Study of Spironolactone 25 mg, 50 mg and 100 mg Tablets

                            Details : Spironolactone is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 09, 2010

                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Actinium pharmaceuticals

                            U.S.A arrow
                            Florida Innovation
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                            Actinium pharmaceuticals

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                            Florida Innovation
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                            Lead Product(s) : Ac-225 Lintuzumab,Spironolactone,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Eckert & Ziegler Strahlen

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Actinium & Eckert-Ziegler Ink Ac-225 Supply Deal for Development Activities

                            Details : Under the agreement, Actinium will have access to Eckert & Ziegler's high-quality Actinium-225 to further develop its lead product Actimab-A (Ac-225 Lintuzumab) for AML.

                            Product Name : Actimab-A

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            March 24, 2025

                            Lead Product(s) : Ac-225 Lintuzumab,Spironolactone,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Eckert & Ziegler Strahlen

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            03

                            SPH Sine Pharmaceutical Laboratories Co., Ltd.

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                            Florida Innovation
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                            SPH Sine Pharmaceutical Laboratories Co., Ltd.

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                            Florida Innovation
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                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Bioequivalence Study of Spironolactone Tablets in Healthy Subjects

                            Details : Spironolactone is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            August 30, 2024

                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Pfizer Inc

                            U.S.A arrow
                            Florida Innovation
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                            Pfizer Inc

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                            Florida Innovation
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                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Undisclosed

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to Learn How the Body Processes Spironolactone and Hydrochlorothiazide Film Coated Tablets Manufacture...

                            Details : Spironolactone is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 16, 2024

                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Undisclosed

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            CMP Development

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                            Florida Innovation
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                            CMP Development

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                            Florida Innovation
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                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase IV, Two-part, Open-label Study Assessing the Pharmacokinetics, Safety and Pharmacodynamics of Spironol...

                            Details : Spironolactone is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Edema-associated with Heart Failure.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 01, 2023

                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase IV

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Actinium pharmaceuticals

                            U.S.A arrow
                            Florida Innovation
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                            Actinium pharmaceuticals

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                            Florida Innovation
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                            Lead Product(s) : Ac-225 Lintuzumab,Spironolactone

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : The Division of Cancer Treatment and Diagnosis

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Actinium Signs Cooperative Research and Development Agreement with National Cancer Institute to Further Enhanc...

                            Details : Under the terms of the CRADA, the NCI will serve as sponsor for any clinical trials mutually approved by both parties to study Actimab-A (lintuzumab-Ac225) while Actinium will be responsible for supplying and distributing Actimab-A.

                            Product Name : Actimab-A

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Undisclosed

                            February 06, 2023

                            Lead Product(s) : Ac-225 Lintuzumab,Spironolactone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : The Division of Cancer Treatment and Diagnosis

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            07

                            Actinium pharmaceuticals

                            U.S.A arrow
                            Florida Innovation
                            Not Confirmed

                            Actinium pharmaceuticals

                            U.S.A arrow
                            Florida Innovation
                            Not Confirmed
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                            Lead Product(s) : Ac-225 Lintuzumab,Spironolactone,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : AbbVie Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Actinium to Host KOL Call on November 11th Featuring Actimab-A AML Combination Trials

                            Details : Webinar will highlight CD33 program ARC combination trials; Actimab-A in combination with CLAG-M, and Actimab-A in combination with venetoclax for patients with fit and unfit R/R AML.

                            Product Name : Actimab-A

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            November 11, 2020

                            Lead Product(s) : Ac-225 Lintuzumab,Spironolactone,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : AbbVie Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Actinium pharmaceuticals

                            U.S.A arrow
                            Florida Innovation
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                            Actinium pharmaceuticals

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                            Florida Innovation
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                            Lead Product(s) : Ac-225 Lintuzumab,Spironolactone,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : AbbVie Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Actinium Announces Actimab-A Venetoclax First-in-Human Data Accepted for Poster Presentation at the 62nd ASH A...

                            Details : Actinium's CD33 program is evaluating the clinical utility of Actimab-A, an ARC comprised of the anti-CD33 mAb lintuzumab linked to the potent alpha-emitting radioisotope Actinium-225 or Ac-225.

                            Product Name : Actimab-A

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            November 04, 2020

                            Lead Product(s) : Ac-225 Lintuzumab,Spironolactone,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : AbbVie Inc

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Piedmont Healthcare

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                            Piedmont Healthcare

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                            Florida Innovation
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                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Efficacy of Aldosterone Antagonist Therapy for Prevention of New Atrial Fibrillation

                            Details : Spironolactone is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Atrial Fibrillation.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 29, 2019

                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            University Hospitals Cleveland Medical Center

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                            Florida Innovation
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                            University Hospitals Cleveland Medical Center

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                            Florida Innovation
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                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase IV

                            Sponsor : Relypsa

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Add-On

                            Details : Spironolactone is a Other Small Molecule drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Diabetes Mellitus, Type 2.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            July 24, 2018

                            Lead Product(s) : Spironolactone

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase IV

                            Sponsor : Relypsa

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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