Drugs in Dev.
Endocrinology
Phase II/ Phase III
France 
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Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Study Phase : Phase II/ Phase III
Sponsor : AstraZeneca
Deal Size : $1,050.0 million
Deal Type : Acquisition
AstraZeneca Closes Acquisition of Amolyt Pharma
Details : Through the acquisition, AstraZeneca leverages the AZP-3601 (neboparatide), peptide agonist of the PTH1 receptor. Currently, being evaluated for the treatment of Chronic Hypoparathyroidism.
Product Name : Undisclosed
Product Type : Peptide, Unconjugated
Upfront Cash : $800.0 million
July 15, 2024
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Highest Development Status : Phase II/ Phase III
Sponsor : AstraZeneca
Deal Size : $1,050.0 million
Deal Type : Acquisition

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Lead Product(s) : TOTUM•63
Therapeutic Area : Endocrinology
Study Phase : Phase II/ Phase III
Sponsor : Nestle Health Sciences SA
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : TOTUM•63 is a unique and patented combination of 5 plant extracts that targets the pathophysiological mechanisms of type 2 diabetes. TOTUM•63 benefits from intellectual property validated by patents in the world's leading markets.
Product Name : Undisclosed
Product Type : Plant Extract/Herbal
Upfront Cash : Inapplicable
May 22, 2023
Lead Product(s) : TOTUM•63
Therapeutic Area : Endocrinology
Highest Development Status : Phase II/ Phase III
Sponsor : Nestle Health Sciences SA
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : TOTUM•63
Therapeutic Area : Endocrinology
Study Phase : Phase II/ Phase III
Sponsor : INAF
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : TOTUM-63 is a unique and patented combination of 5 plant extracts that targets the pathophysiological mechanisms of type 2 diabetes, has already been shown to be safe and effective in healthy volunteers in a Phase I/II clinical study.
Product Name : Undisclosed
Product Type : Plant Extract/Herbal
Upfront Cash : Inapplicable
April 29, 2022
Lead Product(s) : TOTUM•63
Therapeutic Area : Endocrinology
Highest Development Status : Phase II/ Phase III
Sponsor : INAF
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : TOTUM•63
Therapeutic Area : Endocrinology
Study Phase : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EASD has selected the positive results of the international Phase II clinical study on TOTUM-63 in prediabetes to be presented next September in its 56th annual meeting. These results were selected by the American Diabetes Association last June 2020.
Product Name : Undisclosed
Product Type : Plant Extract/Herbal
Upfront Cash : Inapplicable
September 21, 2020
Lead Product(s) : TOTUM•63
Therapeutic Area : Endocrinology
Highest Development Status : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : TOTUM•63
Therapeutic Area : Endocrinology
Study Phase : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The REVERSE-IT study will include 600 patients with fasting hyperglycemia ranging from prediabetes to untreated early stage Type 2 Diabetes. The study should confirm the efficacy of TOTUM-63 - at a dose of 5g/day for 6 months.
Product Name : Undisclosed
Product Type : Plant Extract/Herbal
Upfront Cash : Inapplicable
July 15, 2020
Lead Product(s) : TOTUM•63
Therapeutic Area : Endocrinology
Highest Development Status : Phase II/ Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Totum-63
Therapeutic Area : Endocrinology
Study Phase : Phase II/ Phase III
Sponsor : Biofortis Mérieux Nutriscience | Institut Pasteur de Lille
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Totum-63 is a Dietary Supplement drug candidate, which is currently being evaluated in phase II/ phase III clinical studies for the treatment of Prediabetic State.
Product Name : Undisclosed
Product Type : Dietary Supplement
Upfront Cash : Inapplicable
August 16, 2016
Lead Product(s) : Totum-63
Therapeutic Area : Endocrinology
Highest Development Status : Phase II/ Phase III
Sponsor : Biofortis Mérieux Nutriscience | Institut Pasteur de Lille
Deal Size : Inapplicable
Deal Type : Inapplicable
