

Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Jazz Pharmaceuticals
Deal Size : $935.0 million
Deal Type : Acquisition
Jazz Pharmaceuticals Completes Acquisition of Chimerix
Details : Through the acquisition, Jazz will strengthen it's oncology pipeline, which includes ONC201 (dordaviprone). It is being evaluated in the late-stage for the treatment of H3 K27M-mutant diffuse glioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $935.0 million
April 21, 2025
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Jazz Pharmaceuticals
Deal Size : $935.0 million
Deal Type : Acquisition

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Jazz Pharmaceuticals
Deal Size : $935.0 million
Deal Type : Acquisition
Jazz Pharmaceuticals to Acquire Chimerix, Further Diversifying Oncology Portfolio
Details : Through the acquisition, Jazz will strengthen it's oncology pipeline, which includes ONC201 (dordaviprone). It is being in the evaluated late-stage for the treatment of H3 K27M-mutant diffuse glioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $935.0 million
March 05, 2025
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Jazz Pharmaceuticals
Deal Size : $935.0 million
Deal Type : Acquisition

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Chimerix Announces FDA Acceptance and Priority Review of NDA for Dordaviprone
Details : ONC201 (dordaviprone) is a novel first-in-class small molecule imipridone that selectively targets the mitochondrial protease ClpP and dopamine receptor D2 for recurrent H3 K27M-Mutant diffuse glioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
February 18, 2025
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Chimerix Submits Dordaviprone NDA for Accelerated Approval Of Recurrent Diffuse Glioma
Details : ONC201 (dordaviprone) is a novel first-in-class small molecule imipridone that selectively targets the mitochondrial protease ClpP and dopamine receptor D2 for recurrent H3 K27M-Mutant diffuse glioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
December 30, 2024
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Chimerix to Submit Dordaviprone for Accelerated Approval in for H3 K27M-Mutant Glioma
Details : ONC201 (dordaviprone) targets the targets the mitochondrial protease ClpP and dopamine receptor D2. It is being evaluated for the treatment of recurrent H3 K27M-mutant diffuse glioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
December 09, 2024
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Chimerix
Deal Size : Inapplicable
Deal Type : Inapplicable
A Study of ONC201 for Refractory Meningioma
Details : ONC201 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Meningioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
August 28, 2023
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Chimerix
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ONC201 is a new drug candidate that kills cancer cells but not normal cells in laboratory studies and has been previously evaluated in a phase I clinical trial in advanced cancer patients.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
December 08, 2022
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
Details : Dordaviprone is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Glioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
October 14, 2022
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Gustave Roussy
Deal Size : Inapplicable
Deal Type : Inapplicable
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Details : ONC201 is a Other Small Molecule drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Diffuse Intrinsic Pontine Glioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 27, 2022
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Gustave Roussy
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Expanded Access Use of ONC201 in a Patient With Diffuse Intrinsic Pontine Gliomas
Details : ONC201 is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Glioma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
May 26, 2022
Lead Product(s) : Dordaviprone
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
