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Find Clinical Drug Development Pipelines & Deals | PipelineProspector
IFX-1 (vilobelimab) is a first-in-class monoclonal anti-human complement factor C5a antibody, which highly and effectively blocks the biological activity of C5a and demonstrates high selectivity towards its target in human blood.
Vilobelimab, a monoclonal anti-human complement factor C5a antibody, highly and effectively blocks the biological activity of C5a and demonstrates high selectivity towards its target in human blood for treatment in patients with ulcerative pyoderma gangrenosum.
Vilobelimab is a first-in-class monoclonal anti-human complement factor C5a antibody, which highly and effectively blocks the biological activity of C5a and demonstrates high selectivity towards its target in human blood.
The study met the primary endpoint, where 54% of patients had no visible pustules after a single dose of BI 655130 (spesolimab), compared to 6% receiving placebo at week one. Spesolimab has been granted Breakthrough Therapy Designation in China and USA.
Lead Product(s):
Spesolimab
Therapeutic Area:DermatologyProduct Name: BI 655130
Highest Development Status:Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
USFDA has accepted BLA and granted Priority Review for BI 655130 (spesolimab), a novel, humanized, selective antibody that blocks the activation of the interleukin-36 receptor for the treatment of generalized pustular psoriasis.
Lead Product(s):
Spesolimab
Therapeutic Area:DermatologyProduct Name: BI 655130
Highest Development Status:Phase IIProduct Type: Large molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not ApplicableUpfront Cash: Not Applicable
Vilobelimab is a first-in-class monoclonal anti-human complement factor C5a antibody, which highly and effectively blocks the biological activity of C5a and demonstrates high selectivity towards its target in human blood.
The main objectives of the study are the evaluation of the safety and efficacy of vilobelimab in patients with PG. Target enrollment of 18 patients reached across three different dose groups.
Two out of the first five patients dosed with IFX-1 achieved complete remission. Dose escalation warranted by pharmacodynamic analysis and approved by relevant authorities in 3 dose cohorts.