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    [{"orgOrder":0,"company":"Daiichi Sankyo","sponsor":"Immunic Therapeutics","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Immunic Exercises Option to License Daiichi\u2019s IMU-856","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Preclinical","country":"JAPAN","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2020","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Preclinical"},{"orgOrder":0,"company":"Daiichi Sankyo","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Phase 2 DESTINY-Gastric01 Trial of DS-8201 Versus Chemotherapy Met Primary Endpoint","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase II","country":"JAPAN","productType":"Large molecule","productStatus":"Approved","date":"January 2020","url1":"","url2":"","graph1":"Oncology","graph2":"Phase 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Tumors","therapeuticArea":"Oncology","highestDevelopmentStatus":"Approved","country":"JAPAN","productType":"Large molecule","productStatus":"Approved","date":"April 2024","url1":"","url2":"","graph1":"Oncology","graph2":"Approved"}]

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              Daiichi Sankyo

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              REJOICE-Ovarian01 Phase 2/3 Trial of Raludotatug Deruxtecan Initiated in Patients with Platinum-Resistant Ovarian Cancer

              Details:

              R-DXd (raludotatug deruxtecan) potential first-in-class CDH6 directed DXd antibody drug conjugate. It is being evaluated for the treatment of patients with platinum-resistant ovarian cancer.

              Lead Product(s): Raludotatug Deruxtecan

              Therapeutic Area: Oncology Product Name: R-DXd

              Highest Development Status: Phase II/ Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Merck & Co

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable April 03, 2024

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              Daiichi Sankyo

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              Datopotamab Deruxtecan Biologics License Application Accepted in the US for Patients with Previously Treated Metastatic HR-positive, HER2-negative Breast Cancer

              Details:

              Dato-DXd (datopotamab deruxtecan) is an investigational TOP1 & TROP2 directed ADC comprised of a humanized anti-TROP2 IgG1 monoclonal antibody, which is being evaluated for the treatment of advanced HR positive, HER2 negative breast cancer.

              Lead Product(s): Datopotamab Deruxtecan

              Therapeutic Area: Oncology Product Name: Dato-DXd

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: AstraZeneca

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable April 02, 2024

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              Daiichi Sankyo

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              CHMP Issues Positive Opinions for Both Bempedoic Acid and The Bempedoic Acid / Ezetimibe Fixed-Dose Combination Tablet as Treatments for Hypercholesterolaemia and Significa...

              Details:

              Nilemdo(bempedoic acid) is an adenosine triphosphate-citrate lyase (ACL) inhibitor indicated as an adjunct to diet and statin therapy for the treatment of heart attack, hypercholesterolaemia & cardiovascular diseases.

              Lead Product(s): Bempedoic Acid

              Therapeutic Area: Cardiology/Vascular Diseases Product Name: Nilemdo

              Highest Development Status: Approved Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 22, 2024

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              Daiichi Sankyo

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              Datopotamab Deruxtecan New Drug Application Submitted in Japan for Patients with Previously Treated Advanced HR Positive, HER2 Negative Breast Cancer

              Details:

              Dato-DXd (datopotamab deruxtecan) is an investigational TOP1 & TROP2 directed ADC comprised of a humanized anti-TROP2 IgG1 monoclonal antibody, which is being evaluated for the treatment of advanced HR positive, HER2 negative breast cancer.

              Lead Product(s): Datopotamab Deruxtecan

              Therapeutic Area: Oncology Product Name: Dato-DXd

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 14, 2024

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              Expiration of Marketing Alliance Agreement for TENELIA® Tablets, TENELIA® OD Tablets and CANAGLU® Tablets

              Details:

              Under the expiration of the agreement, Daiichi will transfer the distribution rights of Tenelia (teneligliptin) to Mitsubishi and will end the information provision activities to medical institutions for all products, which are currently jointly conducted with Mitsubishi.

              Lead Product(s): Teneligliptin

              Therapeutic Area: Endocrinology Product Name: Tenelia

              Highest Development Status: Approved Product Type: Small molecule

              Recipient: Mitsubishi Tanabe Pharma

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Termination March 04, 2024

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              Two Datopotamab Deruxtecan Applications Validated in the EU for Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer or HR-Positive, HER2-Negative Breast Cancer

              Details:

              DS-1062a (datopotamab deruxtecan) is a TROP2-directed DXd antibody-drug conjugate. It is currently being evaluated in the Phase III clinical studies for the treatment of Advanced Nonsquamous Non-Small Cell Lung Cancer and HR Positive/HER2 Negative breast cancer.

              Lead Product(s): Datopotamab Deruxtecan

              Therapeutic Area: Oncology Product Name: DS-1062a

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: AstraZeneca

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 04, 2024

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              Daiichi Sankyo

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              Datopotamab Deruxtecan Biologics License Application Accepted in the US for Patients with Previously Treated Advanced Nonsquamous Non-Small Cell Lung Cancer

              Details:

              DS-1062a (datopotamab deruxtecan) is an investigational TOP1 & TROP2 directed ADC comprised of a humanized anti-TROP2 IgG1 monoclonal antibody, which is being evaluated for the treatment of advanced nonsquamous non-small cell lung cancer.

              Lead Product(s): Datopotamab Deruxtecan

              Therapeutic Area: Oncology Product Name: DS-1062a

              Highest Development Status: Phase III Product Type: Large molecule

              Partner/Sponsor/Collaborator: AstraZeneca

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable February 19, 2024

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              EZHARMIA® Supplemental New Drug Application Submitted in Japan for Patients with Peripheral T-Cell Lymphoma

              Details:

              Ezharmia (valemetostat tosilate) is a first-in-class dual inhibitor of EZH1 and EZH2. It is being evaluated for the treatment of adult patients with relapsed or refractory peripheral T-cell lymphoma.

              Lead Product(s): Valemetostat

              Therapeutic Area: Oncology Product Name: Ezharmia

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 31, 2024

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              Enhertu Granted Priority Review in The US for Patients with Metastatic HER2-positive Solid Tumours

              Details:

              Enhertu (trastuzumab deruxtecan) is a HER2-directed antibody-drug conjugate which is being evaluated in phase 3 clinical trials for the treatment of patients with unresectable or metastatic HER2-expressing advanced solid tumours.

              Lead Product(s): Deruxtecan

              Therapeutic Area: Oncology Product Name: Enhertu

              Highest Development Status: Phase II Product Type: Large molecule

              Recipient: AstraZeneca

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 29, 2024

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              Esperion and Daiichi Sankyo Europe Announce $125 Million Amendment to Their Collaboration, Including Resolution of Pending Litigation

              Details:

              The collaboration combines Esperion Therapeutics’ first-in-class ATP Citrate Lyase (ACL) inhibitor, NILEMDO (bempedoic acid), with Daiichi Sankyo’s commercial capabilities, as well as synergies with their existing portfolio of cardiovascular medicines.

              Lead Product(s): Bempedoic Acid

              Therapeutic Area: Cardiology/Vascular Diseases Product Name: Nilemdo

              Highest Development Status: Approved Product Type: Small molecule

              Recipient: Esperion Therapeutics

              Deal Size: $1,255.0 million Upfront Cash: $30.0 million

              Deal Type: Collaboration January 03, 2024

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              Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.
              ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.
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