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Find Clinical Drug Pipeline Developments & Deals for Dabrafenib
Details :
Tafinlar is a combination of dabrafenib mesylate and trametinib that targets two different kinases in the RAS/RAF/MEK/ERK pathway. This combination resulted in greater growth inhibition of BRAF V600 mutation-positive tumor cell lines.
Details :
JSI-1187 is a selective and orally administered small molecule inhibitor of ERK1 and ERK2. In preclinical studies, JSI-1187 demonstrated high potency against a variety of tumors with MAPK pathway mutations.
Details :
E6201 is an ATP-competitive MEK1 inhibitor that has demonstrated preclinical activity in BRAF V600-mutant melanoma cell lines. E6201 has shown excellent brain distribution characteristics and minimal CNS efflux by transporters at the BBB.
Details :
FDA approval was based on clinical efficacy and safety demonstrated in three clinical trials. In Phase II ROAR basket study and NCI-MATCH Subprotocol H study, Tafinlar (dabrafenib mesylate) + Mekinist resulted in overall response rates of up to 80% in pa...
Details :
Treatment with targeted therapies Tafinlar (dabrafenib)+ Mekinist resulted in 47% ORR versus chemotherapy and reduced risk of progression or death by 69%, showing significant efficacy improvement in patients with BRAF V600 LGG requiring first systemic tr...
Sponsor :
Royal North Shore Hospital | Austin Health | Sir Charles Gairdner Hospital | Monash Health | Peter MacCallum Cancer Centre | Royal Brisbane and Women's Hospital | Eastern Health | The Alfred | Royal Adelaide Hospital
Sponsor :
Royal North Shore Hospital | Austin Health | Sir Charles Gairdner Hospital | Monash Health | Peter MacCallum Cancer Centre | Royal Brisbane and Women's Hospital | Eastern Health | The Alfred | Royal Adelaide Hospital
Details :
In a paper published by Science Advances, Creighton scientists and students involved in the research found that dabrafenib can be repurposed to prevent cisplatin- and noise-induced hearing loss in mice.
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