Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : CYT-338
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CYT-338 is a tetravalent IgG1-like multifunctional NK cell engager antibody with a novel FLEX-linker that simultaneously binds CD38-expressing cells and NK cells via the activation receptor NKp46.
Product Name : CYT-338
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
October 27, 2022
Lead Product(s) : CYT-338
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CYT-338
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CYT-338 is a tetravalent IgG1-like multifunctional NK cell engager antibody with a novel FLEX-linker that simultaneously binds CD38-expressing cells and NK cells via the activating receptor NKp46.
Product Name : CYT-338
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
October 06, 2022
Lead Product(s) : CYT-338
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CYT-303,iNK Cell
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : First in vivo data demonstrated anti-tumor activity of Glypican-3 (GPC3) Flex-NK™ cell engager CYT-303 in combination with iNK cells in an animal model of Hepatocellular carcinoma (HCC).
Product Name : CYT-303
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
August 04, 2022
Lead Product(s) : CYT-303,iNK Cell
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CYT-303,Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Isleworth Healthcare Acquisition Corp.
Deal Size : Undisclosed
Deal Type : Merger
Details : In addition, CYT-503, a GPC3-targeting CAR-iNK cell therapeutic, is designed to improve specificity for tumor targeting. Cytovia expects to file INDs for CYT-303 and CYT-100, followed by INDs for CYT-150 and CYT-503.
Product Name : CYT-303
Product Type : Cell and Gene therapy
Upfront Cash : Undisclosed
April 26, 2022
Lead Product(s) : CYT-303,Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Isleworth Healthcare Acquisition Corp.
Deal Size : Undisclosed
Deal Type : Merger
Lead Product(s) : CYT-303
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CYT 303 is a FLEX-NK® tetravalent bispecific trifunctional antibody targeting GPC3, a glycoprotein highly expressed on solid tumors, including Hepatocellular carcinoma, but not on adult healthy cells, is being developed to treat solid tumors expressing ...
Product Name : CYT-303
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
March 16, 2022
Lead Product(s) : CYT-303
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CYT-303
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : TF Capital
Deal Size : $45.0 million
Deal Type : Financing
Details : TF Capital, a leading China-based biotech institutional investor and Cytovia have formed CytoLynx Therapeutics, and invests to finance the IND enabling and initial clinical development of the pipeline programs including CYT-303.
Product Name : CYT-303
Product Type : Cell and Gene therapy
Upfront Cash : Undisclosed
September 13, 2021
Lead Product(s) : CYT-303
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : TF Capital
Deal Size : $45.0 million
Deal Type : Financing
Lead Product(s) : CYT-100
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : CytoLynx
Deal Size : Undisclosed
Deal Type : Collaboration
Details : CytoLynx obtained a technology license from Cytovia based on its core technologies to allow in-China development of additional NK therapeutics for global commercialization including CYT-100.
Product Name : CYT-100
Product Type : Cell and Gene therapy
Upfront Cash : $400.0 million
September 13, 2021
Lead Product(s) : CYT-100
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : CytoLynx
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : CYT-503
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : National Institutes of Health
Deal Size : Undisclosed
Deal Type : Partnership
Details : Cytovia has signed a licensing agreement with the National Cancer Institute (NCI), part of the National Institutes of Health, to apply its gene-edited iPSC-derived NK cell technology to develop GPC3 CAR NK cell therapeutics.
Product Name : CYT-503
Product Type : Cell and Gene therapy
Upfront Cash : Undisclosed
January 13, 2021
Lead Product(s) : CYT-503
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : National Institutes of Health
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : CYT-101
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The use of iPSC-NK cells constitutes a transformational approach to cancer treatment, enabling the use of precision cell therapy for many patients. Cytovia plans to initiate first clinical trials with iPSC NK-cells in 2021.
Product Name : CYT-101
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
August 25, 2020
Lead Product(s) : CYT-101
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable