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Find Clinical Drug Pipeline Developments & Deals by COVAXX
The collaboration aims to helps Vaxxinity to work on the development of UB-311, which targets toxic forms of aggregated Aβ in the brain to fight Alzheimer disaease.
The collaboration aims to further the development of Vaxxinity’s active immunotherapies to prevent and mitigate muscle and bone wasting and to assess its effects on undisclosed proteins through in vitro and in vivo experiments, and animal models established by UCF.
UB-312 is a vaccine candidate targeting pathological forms of alpha-synuclein (aSyn) for the disease-modifying treatment and prevention of Parkinson’s disease (PD) and other synucleinopathies.
VXX-401 is an investigational vaccine designed to lower low-density lipoprotein (LDL) cholesterol, a known factor contributing to heart disease, by targeting proprotein convertase subtilisin/kexin type 9 serine protease (PCSK9).
UB-612 is the first multitope subunit protein/peptide-based vaccine candidate for SARS-CoV-2, designed to activate both B- and T-cell arms of the immune system directed against multiple structural viral antigens.
Preclinically, UB-313 has shown strong immunogenicity across species, inducing anti-CGRP antibodies with similar properties as approved comparator monoclonal antibodies, as well as a favorable safety and tolerability profile.
UB-612 is the first multitope subunit protein/peptide-based vaccine candidate for SARS-CoV-2, which is designed to activate both B- and T-cell arms of the immune system directed against multiple structural viral antigens.
UB-311 is a fully synthetic vaccine candidate that employs the UBITh platform technologies to target aggregated forms of beta-amyloid in the brain to treat Alzheimer’s disease.
Long Term Extension trials showed UB-311 to be well tolerated in mild-to-moderate AD patients over three years of repeat dosing, with a safety profile comparable to placebo and no cases of amyloid-related imaging abnormalities-edema (“ARIA-E”) in the main study.
Outlines preliminary evidence suggesting UB-312 is well tolerated and induces dose-dependent antibody production, with high titer levels detectable in cerebrospinal fluid (CSF), a key characteristic for tackling diseases of the brain.
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